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Clinical and diagnostic findings of an echovirus meningitis outbreak in the north west of England.
Postgrad Med J. 2006 Jan; 82(963):60-4.PM

Abstract

INTRODUCTION

An outbreak of echovirus meningitis occurred in the north west of England in 2001. This paper reviewed the clinical features and the role of different diagnostic methods.

METHODS

This was a prospective study of adults admitted to a regional infectious disease unit with a probable diagnosis of meningitis, March to August 2001.

RESULTS

Half the 40 cases were male; median age was 28 (range 16-51) years. Fifteen of 38 (39.5%) were smokers, and 20 of 24 (83.3%) had close contact with children. Median (range) duration of symptoms was 1.1 (0.25-7) days. Symptoms included headache (100%), photophobia (87.5%), and nausea (67.5%), and severity ranged from minimal signs to those consistent with a meningoencephalitis. The diagnosis was confirmed virologically in 29 of 40 (72%); echovirus 30 was isolated from six. Cerebrospinal fluid (CSF) enterovirus polymerase chain reaction (PCR) was positive in 26 of 32 (81%), and CSF virus culture in 3 of 16 (19%). Thirty one per cent of CSF samples had a neutrophil predominance, and 3 of 29 (10%) virologically confirmed cases had normal CSF microscopy and biochemistry.

CONCLUSION

CSF microscopy may be normal or suggest bacterial meningitis in a substantial minority of cases of echovirus meningitis. CSF PCR for enterovirus seems to be more sensitive than virus culture of CSF, although PCR does not yield information on circulating virus type. Early and accurate diagnosis could reduce both use of parenteral antibiotics and length of hospital stay with both morbidity and cost implications. Close contact with children may be a risk factor, particularly if good hygiene measures are not practised.

Authors+Show Affiliations

Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16397083

Citation

Carrol, E D., et al. "Clinical and Diagnostic Findings of an Echovirus Meningitis Outbreak in the North West of England." Postgraduate Medical Journal, vol. 82, no. 963, 2006, pp. 60-4.
Carrol ED, Beadsworth MB, Jenkins N, et al. Clinical and diagnostic findings of an echovirus meningitis outbreak in the north west of England. Postgrad Med J. 2006;82(963):60-4.
Carrol, E. D., Beadsworth, M. B., Jenkins, N., Ratcliffe, L., Ashton, I., Crowley, B., Nye, F. J., & Beeching, N. J. (2006). Clinical and diagnostic findings of an echovirus meningitis outbreak in the north west of England. Postgraduate Medical Journal, 82(963), 60-4.
Carrol ED, et al. Clinical and Diagnostic Findings of an Echovirus Meningitis Outbreak in the North West of England. Postgrad Med J. 2006;82(963):60-4. PubMed PMID: 16397083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and diagnostic findings of an echovirus meningitis outbreak in the north west of England. AU - Carrol,E D, AU - Beadsworth,M B J, AU - Jenkins,N, AU - Ratcliffe,L, AU - Ashton,I, AU - Crowley,B, AU - Nye,F J, AU - Beeching,N J, PY - 2006/1/7/pubmed PY - 2006/7/22/medline PY - 2006/1/7/entrez SP - 60 EP - 4 JF - Postgraduate medical journal JO - Postgrad Med J VL - 82 IS - 963 N2 - INTRODUCTION: An outbreak of echovirus meningitis occurred in the north west of England in 2001. This paper reviewed the clinical features and the role of different diagnostic methods. METHODS: This was a prospective study of adults admitted to a regional infectious disease unit with a probable diagnosis of meningitis, March to August 2001. RESULTS: Half the 40 cases were male; median age was 28 (range 16-51) years. Fifteen of 38 (39.5%) were smokers, and 20 of 24 (83.3%) had close contact with children. Median (range) duration of symptoms was 1.1 (0.25-7) days. Symptoms included headache (100%), photophobia (87.5%), and nausea (67.5%), and severity ranged from minimal signs to those consistent with a meningoencephalitis. The diagnosis was confirmed virologically in 29 of 40 (72%); echovirus 30 was isolated from six. Cerebrospinal fluid (CSF) enterovirus polymerase chain reaction (PCR) was positive in 26 of 32 (81%), and CSF virus culture in 3 of 16 (19%). Thirty one per cent of CSF samples had a neutrophil predominance, and 3 of 29 (10%) virologically confirmed cases had normal CSF microscopy and biochemistry. CONCLUSION: CSF microscopy may be normal or suggest bacterial meningitis in a substantial minority of cases of echovirus meningitis. CSF PCR for enterovirus seems to be more sensitive than virus culture of CSF, although PCR does not yield information on circulating virus type. Early and accurate diagnosis could reduce both use of parenteral antibiotics and length of hospital stay with both morbidity and cost implications. Close contact with children may be a risk factor, particularly if good hygiene measures are not practised. SN - 1469-0756 UR - https://www.unboundmedicine.com/medline/citation/16397083/Clinical_and_diagnostic_findings_of_an_echovirus_meningitis_outbreak_in_the_north_west_of_England_ L2 - https://pmj.bmj.com/lookup/pmidlookup?view=long&pmid=16397083 DB - PRIME DP - Unbound Medicine ER -