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Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa.
J Vet Med Sci. 2005 Dec; 67(12):1243-7.JV

Abstract

The antifungal activity of beta-thujaplicin was evaluated against 51 Malassezia pachydermatis strains isolated from canine ear canals with or without otitis externa. For comparison, sensitivity tests were performed on M. pachydermatis isolates for nystatin, ketoconazole, and terbinafine HCl, all clinically available antifungal agents. The minimal inhibition concentrations over 50% of the tested isolates (MIC50) were 3.13 microg/ml for beta-thujaplicin and nystatin, 0.016 microg/ml for ketoconazole, and 1.56 microg/ml for terbinafine HCl. The antifungal effect for M. pachydermatis of beta-thujaplicin compared favorably with commercial antifungal agents. None of the 51 M. pachydermatis isolates showed resistance against any of the tested antibiotics investigated in this study. Ten representative isolates of M. pachydermatis were subcultured for 30 generations at concentrations close to the MIC levels of beta-thujaplicin, nystatin, ketoconazole, and terbinafine HCl, and examined to determine whether they had acquired resistance to each drug. As a result, M. pachydermatis was found to achieve resistance more easily for ketoconazole and terbinafine HCl than for beta-thujaplicin or nystatin. The MIC50 of beta-thujaplicin did not change during the course of subculture, and it is thought that the potential development of a resistant strain is low, even with continuous infusion for otitis externa therapy. beta-Thujaplicin is an inexpensive and safe treatment with anti-inflammatory and deodorant effects that can be recommended as an effective remedy for canine otitis externa.

Authors+Show Affiliations

Department of Veterinary Clinical Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16397383

Citation

Nakano, Yasuyuki, et al. "Effects of Beta-thujaplicin On anti-Malassezia Pachydermatis Remedy for Canine Otitis Externa." The Journal of Veterinary Medical Science, vol. 67, no. 12, 2005, pp. 1243-7.
Nakano Y, Wada M, Tani H, et al. Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa. J Vet Med Sci. 2005;67(12):1243-7.
Nakano, Y., Wada, M., Tani, H., Sasai, K., & Baba, E. (2005). Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa. The Journal of Veterinary Medical Science, 67(12), 1243-7.
Nakano Y, et al. Effects of Beta-thujaplicin On anti-Malassezia Pachydermatis Remedy for Canine Otitis Externa. J Vet Med Sci. 2005;67(12):1243-7. PubMed PMID: 16397383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa. AU - Nakano,Yasuyuki, AU - Wada,Makoto, AU - Tani,Hiroyuki, AU - Sasai,Kazumi, AU - Baba,Eiichiroh, PY - 2006/1/7/pubmed PY - 2006/8/2/medline PY - 2006/1/7/entrez SP - 1243 EP - 7 JF - The Journal of veterinary medical science JO - J. Vet. Med. Sci. VL - 67 IS - 12 N2 - The antifungal activity of beta-thujaplicin was evaluated against 51 Malassezia pachydermatis strains isolated from canine ear canals with or without otitis externa. For comparison, sensitivity tests were performed on M. pachydermatis isolates for nystatin, ketoconazole, and terbinafine HCl, all clinically available antifungal agents. The minimal inhibition concentrations over 50% of the tested isolates (MIC50) were 3.13 microg/ml for beta-thujaplicin and nystatin, 0.016 microg/ml for ketoconazole, and 1.56 microg/ml for terbinafine HCl. The antifungal effect for M. pachydermatis of beta-thujaplicin compared favorably with commercial antifungal agents. None of the 51 M. pachydermatis isolates showed resistance against any of the tested antibiotics investigated in this study. Ten representative isolates of M. pachydermatis were subcultured for 30 generations at concentrations close to the MIC levels of beta-thujaplicin, nystatin, ketoconazole, and terbinafine HCl, and examined to determine whether they had acquired resistance to each drug. As a result, M. pachydermatis was found to achieve resistance more easily for ketoconazole and terbinafine HCl than for beta-thujaplicin or nystatin. The MIC50 of beta-thujaplicin did not change during the course of subculture, and it is thought that the potential development of a resistant strain is low, even with continuous infusion for otitis externa therapy. beta-Thujaplicin is an inexpensive and safe treatment with anti-inflammatory and deodorant effects that can be recommended as an effective remedy for canine otitis externa. SN - 0916-7250 UR - https://www.unboundmedicine.com/medline/citation/16397383/Effects_of_beta_thujaplicin_on_anti_Malassezia_pachydermatis_remedy_for_canine_otitis_externa_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/jvms/67.1243?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -