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Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease.
Neurobiol Aging 2006; 27(2):262-9NA

Abstract

Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC.

Authors+Show Affiliations

Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16399211

Citation

Guidi, Ilaria, et al. "Oxidative Imbalance in Patients With Mild Cognitive Impairment and Alzheimer's Disease." Neurobiology of Aging, vol. 27, no. 2, 2006, pp. 262-9.
Guidi I, Galimberti D, Lonati S, et al. Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2006;27(2):262-9.
Guidi, I., Galimberti, D., Lonati, S., Novembrino, C., Bamonti, F., Tiriticco, M., ... Scarpini, E. (2006). Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 27(2), pp. 262-9.
Guidi I, et al. Oxidative Imbalance in Patients With Mild Cognitive Impairment and Alzheimer's Disease. Neurobiol Aging. 2006;27(2):262-9. PubMed PMID: 16399211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease. AU - Guidi,Ilaria, AU - Galimberti,Daniela, AU - Lonati,Silvia, AU - Novembrino,Cristina, AU - Bamonti,Fabrizia, AU - Tiriticco,Marco, AU - Fenoglio,Chiara, AU - Venturelli,Eliana, AU - Baron,Pierluigi, AU - Bresolin,Nereo, AU - Scarpini,Elio, Y1 - 2005/02/17/ PY - 2004/10/23/received PY - 2005/01/11/accepted PY - 2006/1/10/pubmed PY - 2006/3/15/medline PY - 2006/1/10/entrez SP - 262 EP - 9 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 27 IS - 2 N2 - Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/16399211/Oxidative_imbalance_in_patients_with_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(05)00016-3 DB - PRIME DP - Unbound Medicine ER -