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Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease.
Neurobiol Aging. 2006 Feb; 27(2):270-7.NA

Abstract

The relative contribution of Alzheimer's disease (AD) hippocampal neuronal pathology in cognitive decline is still a matter of debate. To address this issue, we performed a stereological analysis of layer II of the entorhinal cortex and the CA1 field of the hippocampus in 34 autopsy cases covering the whole spectrum of old age and Clinical Dementia Rating (CDR) scores. In both areas, the proportion of neurofibrillary tangle (NFT)-containing neurons increased steadily as a function of the CDR score. Questionable dementia was associated with a 1.9% neuronal loss in the entorhinal cortex and 26% in the CA1 field. NFT numbers predicted only 38% of the neuron number variability in the entorhinal cortex and 55% in the CA1 field. Neuron counts in the entorhinal cortex and both neuron and NFT counts in the CA1 field were significantly associated with cognitive status explaining 25% and 44% of the CDR variability, respectively. Our data reveal a dissociation between the patterns of progression of NFT and neuronal loss in the entorhinal cortex and CA1 field. Moreover, they show that less than 50% of the cognitive variability may be attributable to AD neuronal pathology in these areas.

Authors+Show Affiliations

Service of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16399212

Citation

von Gunten, Armin, et al. "Cognitive Impact of Neuronal Pathology in the Entorhinal Cortex and CA1 Field in Alzheimer's Disease." Neurobiology of Aging, vol. 27, no. 2, 2006, pp. 270-7.
von Gunten A, Kövari E, Bussière T, et al. Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease. Neurobiol Aging. 2006;27(2):270-7.
von Gunten, A., Kövari, E., Bussière, T., Rivara, C. B., Gold, G., Bouras, C., Hof, P. R., & Giannakopoulos, P. (2006). Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease. Neurobiology of Aging, 27(2), 270-7.
von Gunten A, et al. Cognitive Impact of Neuronal Pathology in the Entorhinal Cortex and CA1 Field in Alzheimer's Disease. Neurobiol Aging. 2006;27(2):270-7. PubMed PMID: 16399212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease. AU - von Gunten,Armin, AU - Kövari,Enikö, AU - Bussière,Thierry, AU - Rivara,Claire-Bénédicte, AU - Gold,Gabriel, AU - Bouras,Constantin, AU - Hof,Patrick R, AU - Giannakopoulos,Panteleimon, Y1 - 2005/04/26/ PY - 2004/06/03/received PY - 2005/01/07/revised PY - 2005/02/18/accepted PY - 2006/1/10/pubmed PY - 2006/3/15/medline PY - 2006/1/10/entrez SP - 270 EP - 7 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 27 IS - 2 N2 - The relative contribution of Alzheimer's disease (AD) hippocampal neuronal pathology in cognitive decline is still a matter of debate. To address this issue, we performed a stereological analysis of layer II of the entorhinal cortex and the CA1 field of the hippocampus in 34 autopsy cases covering the whole spectrum of old age and Clinical Dementia Rating (CDR) scores. In both areas, the proportion of neurofibrillary tangle (NFT)-containing neurons increased steadily as a function of the CDR score. Questionable dementia was associated with a 1.9% neuronal loss in the entorhinal cortex and 26% in the CA1 field. NFT numbers predicted only 38% of the neuron number variability in the entorhinal cortex and 55% in the CA1 field. Neuron counts in the entorhinal cortex and both neuron and NFT counts in the CA1 field were significantly associated with cognitive status explaining 25% and 44% of the CDR variability, respectively. Our data reveal a dissociation between the patterns of progression of NFT and neuronal loss in the entorhinal cortex and CA1 field. Moreover, they show that less than 50% of the cognitive variability may be attributable to AD neuronal pathology in these areas. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/16399212/Cognitive_impact_of_neuronal_pathology_in_the_entorhinal_cortex_and_CA1_field_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(05)00091-6 DB - PRIME DP - Unbound Medicine ER -