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Age at onset: an essential variable for the definition of genetic risk factors for sporadic Alzheimer's disease.
Ann N Y Acad Sci. 2005 Dec; 1057:260-78.AN

Abstract

The aim of our work was to detect minor loci acting as Alzheimer's disease (AD) genetic markers. We divided 206 AD patients and 186 individuals as controls into six age at onset/age-dependent groups. We studied polymorphisms of the genes of apolipoprotein E (APOE) and its promoter, cathepsin D, butyrylcholinesterase, cystatin C, methionine synthase, and cystathionine beta-synthase. Our results demonstrated that data analysis according to age at onset allows the detection of minor genetic risk factors for AD. Thus, the Th1/E47cs-G allele was an independent AD risk factor after 80 years, whereas the catD-T, BChE-K, CBS-844ins68, and CBS-VNTR 19 alleles are independent AD risk factors after 75 years. On the other hand, the CST3-A allele was an independent AD risk factor before 60 years while the CBS-VNTR allele 21 was an independent AD risk factor before 64 years. In contrast, the MS-AA genotype was an AD risk factor unrelated to age at onset. In conclusion, two main tasks remain to be accomplished to facilitate early detection of people at risk of developing AD: (1) the establishment of common criteria to carry out association studies for different genetic markers, including the introduction of AD age at onset as a crucial variable in each study, and (2) the definition of global and population-specific genetic markers for each age at onset AD subgroup.

Authors+Show Affiliations

Department of Pathology, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain. jilaov@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16399900

Citation

Beyer, Katrin, et al. "Age at Onset: an Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease." Annals of the New York Academy of Sciences, vol. 1057, 2005, pp. 260-78.
Beyer K, Lao JI, Latorre P, et al. Age at onset: an essential variable for the definition of genetic risk factors for sporadic Alzheimer's disease. Ann N Y Acad Sci. 2005;1057:260-78.
Beyer, K., Lao, J. I., Latorre, P., & Ariza, A. (2005). Age at onset: an essential variable for the definition of genetic risk factors for sporadic Alzheimer's disease. Annals of the New York Academy of Sciences, 1057, 260-78.
Beyer K, et al. Age at Onset: an Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease. Ann N Y Acad Sci. 2005;1057:260-78. PubMed PMID: 16399900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age at onset: an essential variable for the definition of genetic risk factors for sporadic Alzheimer's disease. AU - Beyer,Katrin, AU - Lao,José I, AU - Latorre,Pilar, AU - Ariza,Aurelio, PY - 2006/1/10/pubmed PY - 2006/7/13/medline PY - 2006/1/10/entrez SP - 260 EP - 78 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1057 N2 - The aim of our work was to detect minor loci acting as Alzheimer's disease (AD) genetic markers. We divided 206 AD patients and 186 individuals as controls into six age at onset/age-dependent groups. We studied polymorphisms of the genes of apolipoprotein E (APOE) and its promoter, cathepsin D, butyrylcholinesterase, cystatin C, methionine synthase, and cystathionine beta-synthase. Our results demonstrated that data analysis according to age at onset allows the detection of minor genetic risk factors for AD. Thus, the Th1/E47cs-G allele was an independent AD risk factor after 80 years, whereas the catD-T, BChE-K, CBS-844ins68, and CBS-VNTR 19 alleles are independent AD risk factors after 75 years. On the other hand, the CST3-A allele was an independent AD risk factor before 60 years while the CBS-VNTR allele 21 was an independent AD risk factor before 64 years. In contrast, the MS-AA genotype was an AD risk factor unrelated to age at onset. In conclusion, two main tasks remain to be accomplished to facilitate early detection of people at risk of developing AD: (1) the establishment of common criteria to carry out association studies for different genetic markers, including the introduction of AD age at onset as a crucial variable in each study, and (2) the definition of global and population-specific genetic markers for each age at onset AD subgroup. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/16399900/Age_at_onset:_an_essential_variable_for_the_definition_of_genetic_risk_factors_for_sporadic_Alzheimer's_disease_ L2 - https://doi.org/10.1196/annals.1322.021 DB - PRIME DP - Unbound Medicine ER -