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Comparison of sirolimus-eluting stent, paclitaxel-eluting stent, and bare metal stent in the treatment of long coronary lesions.
Catheter Cardiovasc Interv. 2006 Feb; 67(2):181-7.CC

Abstract

OBJECTIVE

This study compared the efficacy of the sirolimus-eluting stent (SES), the paclitaxel-eluting stent (PES), and the bare metal stent (BMS) for long coronary lesions.

BACKGROUND

The outcome of drug-eluting stent (DES) implantation in long coronary lesions remains unclear.

METHODS

The study involved 527 patients with de novo long coronary lesions (> or = 24 mm), which were treated with long (> or = 28 mm) SESs (223 lesions), PESs (194 lesions), or BMSs (201 lesions).

RESULTS

Lesions in the SES (36.0 +/- 14.9 mm, P < 0.001) and PES (36.3 +/- 14.5 mm, P < 0.001) groups were longer than those in the BMS group (32.0 +/- 12.3 mm), meaning the two DES groups had longer stented segments than did the BMS group. Six-month angiographic follow-up showed the SES (9.3%, P < 0.001) and PES (21.3%, P < 0.001) groups had lower in-segment restenosis rates than that of the BMS group (42.5%). The rate of major adverse cardiac events (MACE) including death, myocardial infarction, and target lesion revascularization at 9 months was higher in the BMS group (26.6%) than that in the SES (13.0%, P < 0.001) and PES (15.7%, P < 0.001) groups. Posthoc analysis of the two DES groups showed that the in-segment restenosis rate was lower for the SES than that for the PES group (P = 0.002), while the MACE rate was similar.

CONCLUSIONS

The use of DESs for long coronary lesions appears to be safe and more effective than the use of BMSs in terms of restenosis and adverse clinical events. SES use was associated with lower late luminal loss and a lower angiographic restenosis rate compared with PES use.

Authors+Show Affiliations

Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16400663

Citation

Kim, Young-Hak, et al. "Comparison of Sirolimus-eluting Stent, Paclitaxel-eluting Stent, and Bare Metal Stent in the Treatment of Long Coronary Lesions." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, vol. 67, no. 2, 2006, pp. 181-7.
Kim YH, Park SW, Lee CW, et al. Comparison of sirolimus-eluting stent, paclitaxel-eluting stent, and bare metal stent in the treatment of long coronary lesions. Catheter Cardiovasc Interv. 2006;67(2):181-7.
Kim, Y. H., Park, S. W., Lee, C. W., Hong, M. K., Gwon, H. C., Jang, Y., Lee, M. M., Koo, B. K., Oh, D. J., Seung, K. B., Tahk, S. J., Yoon, J., & Park, S. J. (2006). Comparison of sirolimus-eluting stent, paclitaxel-eluting stent, and bare metal stent in the treatment of long coronary lesions. Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, 67(2), 181-7.
Kim YH, et al. Comparison of Sirolimus-eluting Stent, Paclitaxel-eluting Stent, and Bare Metal Stent in the Treatment of Long Coronary Lesions. Catheter Cardiovasc Interv. 2006;67(2):181-7. PubMed PMID: 16400663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of sirolimus-eluting stent, paclitaxel-eluting stent, and bare metal stent in the treatment of long coronary lesions. AU - Kim,Young-Hak, AU - Park,Seong-Wook, AU - Lee,Cheol Whan, AU - Hong,Myeong-Ki, AU - Gwon,Hyeon-Cheol, AU - Jang,Yangsoo, AU - Lee,Myoung Mook, AU - Koo,Bon Kwon, AU - Oh,Dong Joo, AU - Seung,Ki Bae, AU - Tahk,Seung-Jae, AU - Yoon,Junghan, AU - Park,Seung-Jung, PY - 2006/1/10/pubmed PY - 2006/7/14/medline PY - 2006/1/10/entrez SP - 181 EP - 7 JF - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JO - Catheter Cardiovasc Interv VL - 67 IS - 2 N2 - OBJECTIVE: This study compared the efficacy of the sirolimus-eluting stent (SES), the paclitaxel-eluting stent (PES), and the bare metal stent (BMS) for long coronary lesions. BACKGROUND: The outcome of drug-eluting stent (DES) implantation in long coronary lesions remains unclear. METHODS: The study involved 527 patients with de novo long coronary lesions (> or = 24 mm), which were treated with long (> or = 28 mm) SESs (223 lesions), PESs (194 lesions), or BMSs (201 lesions). RESULTS: Lesions in the SES (36.0 +/- 14.9 mm, P < 0.001) and PES (36.3 +/- 14.5 mm, P < 0.001) groups were longer than those in the BMS group (32.0 +/- 12.3 mm), meaning the two DES groups had longer stented segments than did the BMS group. Six-month angiographic follow-up showed the SES (9.3%, P < 0.001) and PES (21.3%, P < 0.001) groups had lower in-segment restenosis rates than that of the BMS group (42.5%). The rate of major adverse cardiac events (MACE) including death, myocardial infarction, and target lesion revascularization at 9 months was higher in the BMS group (26.6%) than that in the SES (13.0%, P < 0.001) and PES (15.7%, P < 0.001) groups. Posthoc analysis of the two DES groups showed that the in-segment restenosis rate was lower for the SES than that for the PES group (P = 0.002), while the MACE rate was similar. CONCLUSIONS: The use of DESs for long coronary lesions appears to be safe and more effective than the use of BMSs in terms of restenosis and adverse clinical events. SES use was associated with lower late luminal loss and a lower angiographic restenosis rate compared with PES use. SN - 1522-1946 UR - https://www.unboundmedicine.com/medline/citation/16400663/Comparison_of_sirolimus_eluting_stent_paclitaxel_eluting_stent_and_bare_metal_stent_in_the_treatment_of_long_coronary_lesions_ L2 - https://doi.org/10.1002/ccd.20586 DB - PRIME DP - Unbound Medicine ER -