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Insulin sensitivity independently influences brachial-ankle pulse-wave velocity in non-diabetic subjects.
Diabet Med. 2005 Dec; 22(12):1701-6.DM

Abstract

AIMS

Measurement of pulse-wave velocity (PWV) is a non-invasive technique for assessing arterial stiffness. Although insulin resistance is associated with intimal-medial thickness of the carotid artery evaluated by B-mode ultrasonography, it is not known whether it is related to PWV. The aim of this study was to determine the relationship between homeostasis model assessment insulin sensitivity index (HOMA-%S) and PWV in non-diabetic subjects. We also examined the effects of oral glucose tolerance test (OGTT) 2-h glucose and plasma high-sensitivity C-reactive protein (CRP) on PWV, as these two parameters are associated with atherosclerosis.

METHODS

A 75-g oral glucose tolerance test was performed in 1934 Japanese subjects who were undergoing health examinations. Of these subjects, we recruited 1541 non-diabetic subjects without chronic or acute inflammation, malignant diseases, autoimmune disorders, elevated serum creatinine levels, and abnormal hepatic function tests. Subjects who had an abnormal ankle/brachial blood pressure index of less than 0.9 were also excluded. Brachial-ankle PWV and plasma high-sensitivity CRP were measured on 1541 subjects who satisfied the admission criteria.

RESULTS

PWV was 12.55+/-1.61 (mean+/-sd) m/s and plasma CRP concentration was 0.4 mg/l (median, range, 0.1-5.8 mg/l) in the study subjects. By multivariate regression analysis, HOMA-%S was found to be an independent negative risk factor for PWV, while systolic blood pressure, age and triglycerides were positively associated with PWV. OGTT 2-h glucose was weakly and independently related to PWV in male subjects. Plasma CRP was not independently associated with PWV.

CONCLUSIONS

Insulin resistance is independently associated with PWV in non-diabetic subjects.

Authors+Show Affiliations

Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, and Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan. kasayama@imed3.med.osaka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16401315

Citation

Kasayama, S, et al. "Insulin Sensitivity Independently Influences Brachial-ankle Pulse-wave Velocity in Non-diabetic Subjects." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 22, no. 12, 2005, pp. 1701-6.
Kasayama S, Saito H, Mukai M, et al. Insulin sensitivity independently influences brachial-ankle pulse-wave velocity in non-diabetic subjects. Diabet Med. 2005;22(12):1701-6.
Kasayama, S., Saito, H., Mukai, M., & Koga, M. (2005). Insulin sensitivity independently influences brachial-ankle pulse-wave velocity in non-diabetic subjects. Diabetic Medicine : a Journal of the British Diabetic Association, 22(12), 1701-6.
Kasayama S, et al. Insulin Sensitivity Independently Influences Brachial-ankle Pulse-wave Velocity in Non-diabetic Subjects. Diabet Med. 2005;22(12):1701-6. PubMed PMID: 16401315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin sensitivity independently influences brachial-ankle pulse-wave velocity in non-diabetic subjects. AU - Kasayama,S, AU - Saito,H, AU - Mukai,M, AU - Koga,M, PY - 2006/1/13/pubmed PY - 2006/5/4/medline PY - 2006/1/13/entrez SP - 1701 EP - 6 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 22 IS - 12 N2 - AIMS: Measurement of pulse-wave velocity (PWV) is a non-invasive technique for assessing arterial stiffness. Although insulin resistance is associated with intimal-medial thickness of the carotid artery evaluated by B-mode ultrasonography, it is not known whether it is related to PWV. The aim of this study was to determine the relationship between homeostasis model assessment insulin sensitivity index (HOMA-%S) and PWV in non-diabetic subjects. We also examined the effects of oral glucose tolerance test (OGTT) 2-h glucose and plasma high-sensitivity C-reactive protein (CRP) on PWV, as these two parameters are associated with atherosclerosis. METHODS: A 75-g oral glucose tolerance test was performed in 1934 Japanese subjects who were undergoing health examinations. Of these subjects, we recruited 1541 non-diabetic subjects without chronic or acute inflammation, malignant diseases, autoimmune disorders, elevated serum creatinine levels, and abnormal hepatic function tests. Subjects who had an abnormal ankle/brachial blood pressure index of less than 0.9 were also excluded. Brachial-ankle PWV and plasma high-sensitivity CRP were measured on 1541 subjects who satisfied the admission criteria. RESULTS: PWV was 12.55+/-1.61 (mean+/-sd) m/s and plasma CRP concentration was 0.4 mg/l (median, range, 0.1-5.8 mg/l) in the study subjects. By multivariate regression analysis, HOMA-%S was found to be an independent negative risk factor for PWV, while systolic blood pressure, age and triglycerides were positively associated with PWV. OGTT 2-h glucose was weakly and independently related to PWV in male subjects. Plasma CRP was not independently associated with PWV. CONCLUSIONS: Insulin resistance is independently associated with PWV in non-diabetic subjects. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/16401315/Insulin_sensitivity_independently_influences_brachial_ankle_pulse_wave_velocity_in_non_diabetic_subjects_ L2 - https://doi.org/10.1111/j.1464-5491.2005.01718.x DB - PRIME DP - Unbound Medicine ER -