Tags

Type your tag names separated by a space and hit enter

The neuropathology of Alzheimer disease in African American and white individuals.
Arch Neurol. 2006 Jan; 63(1):87-90.AN

Abstract

BACKGROUND

Data from neuropathologic studies of the frequency of Alzheimer disease (AD) among African American persons conflict as to whether the neuropathologic phenotype of AD is identical in African American and white persons.

OBJECTIVES

To examine clinical and neuropathologic phenotypes of AD in African American individuals and to compare AD and vascular burdens between African American and white persons.

DESIGN, SETTING, AND PATIENTS

Ten African American decedents who underwent brain autopsy at the Washington University Alzheimer's Disease Research Center were matched for age, sex, and Clinical Dementia Rating with 10 white decedents between January 1, 1990, and January 1, 2000. The presence and degree of neurofibrillary tangles, senile plaques, Lewy bodies, cerebral infarcts, and cerebral amyloid angiopathy were determined.

RESULTS

All 20 individuals had a neuropathologic diagnosis of AD. There were no group differences in the presence or number of infarcts, plaques, tangles, Lewy bodies, or amyloid angiopathy.

CONCLUSION

In this small sample, we found no substantive differences in the neuropathology of AD among African American and white individuals.

Authors+Show Affiliations

Department of Internal Medicine, Neurology, Washington University School of Medicine, St Louis, MO, USA. cwilkins@im.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16401740

Citation

Wilkins, Consuelo H., et al. "The Neuropathology of Alzheimer Disease in African American and White Individuals." Archives of Neurology, vol. 63, no. 1, 2006, pp. 87-90.
Wilkins CH, Grant EA, Schmitt SE, et al. The neuropathology of Alzheimer disease in African American and white individuals. Arch Neurol. 2006;63(1):87-90.
Wilkins, C. H., Grant, E. A., Schmitt, S. E., McKeel, D. W., & Morris, J. C. (2006). The neuropathology of Alzheimer disease in African American and white individuals. Archives of Neurology, 63(1), 87-90.
Wilkins CH, et al. The Neuropathology of Alzheimer Disease in African American and White Individuals. Arch Neurol. 2006;63(1):87-90. PubMed PMID: 16401740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neuropathology of Alzheimer disease in African American and white individuals. AU - Wilkins,Consuelo H, AU - Grant,Elizabeth A, AU - Schmitt,Sarah E, AU - McKeel,Daniel W, AU - Morris,John C, PY - 2006/1/13/pubmed PY - 2006/3/3/medline PY - 2006/1/13/entrez SP - 87 EP - 90 JF - Archives of neurology JO - Arch Neurol VL - 63 IS - 1 N2 - BACKGROUND: Data from neuropathologic studies of the frequency of Alzheimer disease (AD) among African American persons conflict as to whether the neuropathologic phenotype of AD is identical in African American and white persons. OBJECTIVES: To examine clinical and neuropathologic phenotypes of AD in African American individuals and to compare AD and vascular burdens between African American and white persons. DESIGN, SETTING, AND PATIENTS: Ten African American decedents who underwent brain autopsy at the Washington University Alzheimer's Disease Research Center were matched for age, sex, and Clinical Dementia Rating with 10 white decedents between January 1, 1990, and January 1, 2000. The presence and degree of neurofibrillary tangles, senile plaques, Lewy bodies, cerebral infarcts, and cerebral amyloid angiopathy were determined. RESULTS: All 20 individuals had a neuropathologic diagnosis of AD. There were no group differences in the presence or number of infarcts, plaques, tangles, Lewy bodies, or amyloid angiopathy. CONCLUSION: In this small sample, we found no substantive differences in the neuropathology of AD among African American and white individuals. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/16401740/The_neuropathology_of_Alzheimer_disease_in_African_American_and_white_individuals_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.63.1.87 DB - PRIME DP - Unbound Medicine ER -