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Association between protein intake and blood pressure: the INTERMAP Study.

Abstract

BACKGROUND

Findings from epidemiological studies suggest an inverse relationship between individuals' protein intake and their blood pressure.

METHODS

Cross-sectional epidemiological study of 4680 persons, aged 40 to 59 years, from 4 countries. Systolic and diastolic blood pressure was measured 8 times at 4 visits. Dietary intake based on 24-hour dietary recalls was recorded 4 times. Information on dietary supplements was noted. Two 24-hour urine samples were obtained per person.

RESULTS

There was a significant inverse relationship between vegetable protein intake and blood pressure. After adjusting for confounders, blood pressure differences associated with higher vegetable protein intake of 2.8% kilocalories were -2.14 mm Hg systolic and -1.35 mm Hg diastolic (P<.001 for both); after further adjustment for height and weight, these differences were -1.11 mm Hg systolic (P<.01) and -0.71 mm Hg diastolic (P<.05). For animal protein intake, significant positive blood pressure differences did not persist after adjusting for height and weight. For total protein intake (which had a significant interaction with sex), there was no significant association with blood pressure in women, nor in men after adjusting for dietary confounders. There were significant differences in the amino acid content of the diets of persons with high vegetable and low animal protein intake vs the diets of persons with low vegetable and high animal protein intake.

CONCLUSIONS

Vegetable protein intake was inversely related to blood pressure. This finding is consistent with recommendations that a diet high in vegetable products be part of healthy lifestyle for prevention of high blood pressure and related diseases.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London, London, England. p.elliott@imperial.ac.uk

    , , , , , , , , ,

    Source

    Archives of internal medicine 166:1 2006 Jan 09 pg 79-87

    MeSH

    Adult
    Amino Acids
    Biomarkers
    Blood Pressure
    Blood Pressure Determination
    Body Weights and Measures
    Cross-Sectional Studies
    Dietary Proteins
    Female
    Humans
    International Cooperation
    Male
    Micronutrients
    Middle Aged
    Plant Proteins, Dietary
    Regression Analysis
    Sensitivity and Specificity
    Sex Distribution
    Surveys and Questionnaires
    Urea

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16401814

    Citation

    Elliott, Paul, et al. "Association Between Protein Intake and Blood Pressure: the INTERMAP Study." Archives of Internal Medicine, vol. 166, no. 1, 2006, pp. 79-87.
    Elliott P, Stamler J, Dyer AR, et al. Association between protein intake and blood pressure: the INTERMAP Study. Arch Intern Med. 2006;166(1):79-87.
    Elliott, P., Stamler, J., Dyer, A. R., Appel, L., Dennis, B., Kesteloot, H., ... Zhou, B. (2006). Association between protein intake and blood pressure: the INTERMAP Study. Archives of Internal Medicine, 166(1), pp. 79-87.
    Elliott P, et al. Association Between Protein Intake and Blood Pressure: the INTERMAP Study. Arch Intern Med. 2006 Jan 9;166(1):79-87. PubMed PMID: 16401814.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between protein intake and blood pressure: the INTERMAP Study. AU - Elliott,Paul, AU - Stamler,Jeremiah, AU - Dyer,Alan R, AU - Appel,Lawrence, AU - Dennis,Barbara, AU - Kesteloot,Hugo, AU - Ueshima,Hirotsugu, AU - Okayama,Akira, AU - Chan,Queenie, AU - Garside,Daniel B, AU - Zhou,Beifan, PY - 2006/1/13/pubmed PY - 2006/2/8/medline PY - 2006/1/13/entrez SP - 79 EP - 87 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 166 IS - 1 N2 - BACKGROUND: Findings from epidemiological studies suggest an inverse relationship between individuals' protein intake and their blood pressure. METHODS: Cross-sectional epidemiological study of 4680 persons, aged 40 to 59 years, from 4 countries. Systolic and diastolic blood pressure was measured 8 times at 4 visits. Dietary intake based on 24-hour dietary recalls was recorded 4 times. Information on dietary supplements was noted. Two 24-hour urine samples were obtained per person. RESULTS: There was a significant inverse relationship between vegetable protein intake and blood pressure. After adjusting for confounders, blood pressure differences associated with higher vegetable protein intake of 2.8% kilocalories were -2.14 mm Hg systolic and -1.35 mm Hg diastolic (P<.001 for both); after further adjustment for height and weight, these differences were -1.11 mm Hg systolic (P<.01) and -0.71 mm Hg diastolic (P<.05). For animal protein intake, significant positive blood pressure differences did not persist after adjusting for height and weight. For total protein intake (which had a significant interaction with sex), there was no significant association with blood pressure in women, nor in men after adjusting for dietary confounders. There were significant differences in the amino acid content of the diets of persons with high vegetable and low animal protein intake vs the diets of persons with low vegetable and high animal protein intake. CONCLUSIONS: Vegetable protein intake was inversely related to blood pressure. This finding is consistent with recommendations that a diet high in vegetable products be part of healthy lifestyle for prevention of high blood pressure and related diseases. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/16401814/full_citation L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.166.1.79 DB - PRIME DP - Unbound Medicine ER -