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Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study.
Arch Intern Med 2006; 166(1):88-94AI

Abstract

BACKGROUND

Plasma total homocysteine (tHcy) has been associated with hip fracture but not directly with bone mineral density (BMD). We examined the association of hip BMD with levels of plasma tHcy, folate, and vitamin B12 and the methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C polymorphisms.

METHODS

Bone mineral density was measured between 1997 and 2000 in 2268 men and 3070 women, aged 47 to 50 and 71 to 75 years, from the Hordaland Homocysteine Study cohort. Low BMD was defined as BMD in the lowest quintile for each sex and age group. Linear, logistic, and generalized additive regression models were used.

RESULTS

Plasma levels of tHcy were inversely related to BMD among middle-aged and elderly women (P<.001) but not among men. The multiple adjusted odds ratio for low BMD among subjects with high (>or=15 micromol/L [>or=2.02 mg/L]) compared with low (<9 micromol/L [<1.22 mg/L]) tHcy level was 1.96 (95% confidence interval, 1.40-2.75) for women and was not significant for men. Additional adjustments for plasma folate level or intake of calcium and vitamin D did not substantially alter the results. Plasma folate level was associated with BMD in women only. We observed no association between BMD and vitamin B12 level or the MTHFR polymorphisms.

CONCLUSIONS

Elevated tHcy and low folate levels were associated with reduced BMD in women but not in men. These findings suggest that tHcy may be a potential modifiable risk factor for osteoporosis in women.

Authors+Show Affiliations

Department of Public Health and Primary Health Care, Institute of Medicine, University of Bergen, and Department of Rheumatology, Haukeland University Hospital, Norway. clara.gjesdal@isf.uib.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16401815

Citation

Gjesdal, Clara Gram, et al. "Plasma Total Homocysteine Level and Bone Mineral Density: the Hordaland Homocysteine Study." Archives of Internal Medicine, vol. 166, no. 1, 2006, pp. 88-94.
Gjesdal CG, Vollset SE, Ueland PM, et al. Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med. 2006;166(1):88-94.
Gjesdal, C. G., Vollset, S. E., Ueland, P. M., Refsum, H., Drevon, C. A., Gjessing, H. K., & Tell, G. S. (2006). Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Archives of Internal Medicine, 166(1), pp. 88-94.
Gjesdal CG, et al. Plasma Total Homocysteine Level and Bone Mineral Density: the Hordaland Homocysteine Study. Arch Intern Med. 2006 Jan 9;166(1):88-94. PubMed PMID: 16401815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. AU - Gjesdal,Clara Gram, AU - Vollset,Stein Emil, AU - Ueland,Per Magne, AU - Refsum,Helga, AU - Drevon,Christian A, AU - Gjessing,Håkon K, AU - Tell,Grethe S, PY - 2006/1/13/pubmed PY - 2006/2/8/medline PY - 2006/1/13/entrez SP - 88 EP - 94 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 166 IS - 1 N2 - BACKGROUND: Plasma total homocysteine (tHcy) has been associated with hip fracture but not directly with bone mineral density (BMD). We examined the association of hip BMD with levels of plasma tHcy, folate, and vitamin B12 and the methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C polymorphisms. METHODS: Bone mineral density was measured between 1997 and 2000 in 2268 men and 3070 women, aged 47 to 50 and 71 to 75 years, from the Hordaland Homocysteine Study cohort. Low BMD was defined as BMD in the lowest quintile for each sex and age group. Linear, logistic, and generalized additive regression models were used. RESULTS: Plasma levels of tHcy were inversely related to BMD among middle-aged and elderly women (P<.001) but not among men. The multiple adjusted odds ratio for low BMD among subjects with high (>or=15 micromol/L [>or=2.02 mg/L]) compared with low (<9 micromol/L [<1.22 mg/L]) tHcy level was 1.96 (95% confidence interval, 1.40-2.75) for women and was not significant for men. Additional adjustments for plasma folate level or intake of calcium and vitamin D did not substantially alter the results. Plasma folate level was associated with BMD in women only. We observed no association between BMD and vitamin B12 level or the MTHFR polymorphisms. CONCLUSIONS: Elevated tHcy and low folate levels were associated with reduced BMD in women but not in men. These findings suggest that tHcy may be a potential modifiable risk factor for osteoporosis in women. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/16401815/Plasma_total_homocysteine_level_and_bone_mineral_density:_the_Hordaland_Homocysteine_Study_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.166.1.88 DB - PRIME DP - Unbound Medicine ER -