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Effect of metal complexes of acyclovir and its acetylated derivative on Herpes simplex virus 1 and Herpes simplex virus 2 replication.
Acta Virol. 2005; 49(4):251-60.AV

Abstract

The effect of zinc, nickel, cobalt and cadmium complexes of acyclovir (ACV) and its omicron-acetylated derivative (Ac-ACV) on the replication of wild type (wt) and ACV-resistant (ACV(R)) strains of Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2) was examined. According to cytotoxicity, these compounds followed the order Ni-ACV chloride > Cd-ACV 3 Ni-ACV nitrate > ACV = Zn-ACV nitrate = Ac-ACV = Zn-Ac-ACV > Zn-ACV chloride > Co-ACV. Besides Ac-ACV, the only active complexes in inhibiting virus replication were Zn-ACV nitrate and Zn-Ac-ACV, which effectively suppressed the growth of both wt and ACVR strains of HSV-1 and HSV-2. The most active and most selective inhibitor of the growth of ACVR strains of HSV-1 and HSV-2 was Ac-ACV; its EC50 and SI were 100 and 10 times higher than those of ACV, respectively. Zn-Ac-ACV was less active than Ac-ACV, obviously due to the stability of the complex. Zn-ACV nitrate was active against both wt and ACVR strains of HSV-1; its activity and selectivity were 100 and 75 times higher than those of ACV, respectively. Ac-ACV and Zn-Ac-ACV suppressed the pre-mitotic arrest caused by HSV-1 infection during the first 2 hrs of infection and later on restored the cell division.

Authors+Show Affiliations

Varadinova T
Laboratory of Virology, Faculty of Biology, Sofia University, 8 Dragan Tzankov Blvd, 1164 Sofia, Bulgaria. tvaradinova@biofac.uni-sofia.bg
Vilhelmova N
No affiliation info available
Badenas F
No affiliation info available
Terrón A
No affiliation info available
Fiol J
No affiliation info available
Garcia-Raso A
No affiliation info available
Genova P
No affiliation info available

MeSH

AcyclovirAnimalsAntiviral AgentsCell DivisionCell LineDrug EvaluationHerpesvirus 1, HumanHerpesvirus 2, HumanMetalsVirus Replication

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16402682

Citation

Varadinova, T, et al. "Effect of Metal Complexes of Acyclovir and Its Acetylated Derivative On Herpes Simplex Virus 1 and Herpes Simplex Virus 2 Replication." Acta Virologica, vol. 49, no. 4, 2005, pp. 251-60.
Varadinova T, Vilhelmova N, Badenas F, et al. Effect of metal complexes of acyclovir and its acetylated derivative on Herpes simplex virus 1 and Herpes simplex virus 2 replication. Acta Virol. 2005;49(4):251-60.
Varadinova, T., Vilhelmova, N., Badenas, F., Terrón, A., Fiol, J., Garcia-Raso, A., & Genova, P. (2005). Effect of metal complexes of acyclovir and its acetylated derivative on Herpes simplex virus 1 and Herpes simplex virus 2 replication. Acta Virologica, 49(4), 251-60.
Varadinova T, et al. Effect of Metal Complexes of Acyclovir and Its Acetylated Derivative On Herpes Simplex Virus 1 and Herpes Simplex Virus 2 Replication. Acta Virol. 2005;49(4):251-60. PubMed PMID: 16402682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of metal complexes of acyclovir and its acetylated derivative on Herpes simplex virus 1 and Herpes simplex virus 2 replication. AU - Varadinova,T, AU - Vilhelmova,N, AU - Badenas,F, AU - Terrón,A, AU - Fiol,J, AU - Garcia-Raso,A, AU - Genova,P, PY - 2006/1/13/pubmed PY - 2006/4/28/medline PY - 2006/1/13/entrez SP - 251 EP - 60 JF - Acta virologica JO - Acta Virol VL - 49 IS - 4 N2 - The effect of zinc, nickel, cobalt and cadmium complexes of acyclovir (ACV) and its omicron-acetylated derivative (Ac-ACV) on the replication of wild type (wt) and ACV-resistant (ACV(R)) strains of Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2) was examined. According to cytotoxicity, these compounds followed the order Ni-ACV chloride > Cd-ACV 3 Ni-ACV nitrate > ACV = Zn-ACV nitrate = Ac-ACV = Zn-Ac-ACV > Zn-ACV chloride > Co-ACV. Besides Ac-ACV, the only active complexes in inhibiting virus replication were Zn-ACV nitrate and Zn-Ac-ACV, which effectively suppressed the growth of both wt and ACVR strains of HSV-1 and HSV-2. The most active and most selective inhibitor of the growth of ACVR strains of HSV-1 and HSV-2 was Ac-ACV; its EC50 and SI were 100 and 10 times higher than those of ACV, respectively. Zn-Ac-ACV was less active than Ac-ACV, obviously due to the stability of the complex. Zn-ACV nitrate was active against both wt and ACVR strains of HSV-1; its activity and selectivity were 100 and 75 times higher than those of ACV, respectively. Ac-ACV and Zn-Ac-ACV suppressed the pre-mitotic arrest caused by HSV-1 infection during the first 2 hrs of infection and later on restored the cell division. SN - 0001-723X UR - https://www.unboundmedicine.com/medline/citation/16402682/Effect_of_metal_complexes_of_acyclovir_and_its_acetylated_derivative_on_Herpes_simplex_virus_1_and_Herpes_simplex_virus_2_replication_ DB - PRIME DP - Unbound Medicine ER -