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A review of antioxidants and Alzheimer's disease.
Ann Clin Psychiatry. 2005 Oct-Dec; 17(4):269-86.AC

Abstract

BACKGROUND

In this article, we review a diverse body of research and draw conclusions about the usefulness, or lack there-of, of specific antioxidants in the prevention of Alzheimer's disease (AD).

METHODS

The National Library of Medicine's database was searched for the years 1996-2004 using the search terms "Alzheimer's, anti-oxidants, antioxidants."

RESULTS

Over 300 articles were identified and 187 articles were selected for inclusion based on relevance to the topic. Agents that show promise in helping prevent AD include: 1) aged garlic extract, 2) curcumin, 3) melatonin, 4) resveratrol, 5) Ginkgo biloba extract, 6) green tea, 7) vitamin C and 8) vitamin E.

CONCLUSIONS

While the clinical value of antioxidants for the prevention of AD is often ambiguous, some can be recommended based upon: 1) epidemiological evidence, 2) known benefits for prevention of other maladies, and 3) benign nature of the substance. Long-term, prospective studies are recommended.

Authors+Show Affiliations

Frank B
Department of Psychiatry, University of Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA. bfrank@eastwestnetwork.com
Gupta S
No affiliation info available

MeSH

AcetylcarnitineAgedAged, 80 and overAlzheimer DiseaseAntioxidantsAscorbic AcidBrainCoumaric AcidsGinkgo bilobaHumansLipid PeroxidationMelatoninNerve DegenerationOxidative StressPanaxPhytotherapyThioctic AcidVitamin E

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16402761

Citation

Frank, Bradford, and Sanjay Gupta. "A Review of Antioxidants and Alzheimer's Disease." Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists, vol. 17, no. 4, 2005, pp. 269-86.
Frank B, Gupta S. A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry. 2005;17(4):269-86.
Frank, B., & Gupta, S. (2005). A review of antioxidants and Alzheimer's disease. Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists, 17(4), 269-86.
Frank B, Gupta S. A Review of Antioxidants and Alzheimer's Disease. Ann Clin Psychiatry. 2005 Oct-Dec;17(4):269-86. PubMed PMID: 16402761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of antioxidants and Alzheimer's disease. AU - Frank,Bradford, AU - Gupta,Sanjay, PY - 2006/1/13/pubmed PY - 2006/3/24/medline PY - 2006/1/13/entrez SP - 269 EP - 86 JF - Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists JO - Ann Clin Psychiatry VL - 17 IS - 4 N2 - BACKGROUND: In this article, we review a diverse body of research and draw conclusions about the usefulness, or lack there-of, of specific antioxidants in the prevention of Alzheimer's disease (AD). METHODS: The National Library of Medicine's database was searched for the years 1996-2004 using the search terms "Alzheimer's, anti-oxidants, antioxidants." RESULTS: Over 300 articles were identified and 187 articles were selected for inclusion based on relevance to the topic. Agents that show promise in helping prevent AD include: 1) aged garlic extract, 2) curcumin, 3) melatonin, 4) resveratrol, 5) Ginkgo biloba extract, 6) green tea, 7) vitamin C and 8) vitamin E. CONCLUSIONS: While the clinical value of antioxidants for the prevention of AD is often ambiguous, some can be recommended based upon: 1) epidemiological evidence, 2) known benefits for prevention of other maladies, and 3) benign nature of the substance. Long-term, prospective studies are recommended. SN - 1040-1237 UR - https://www.unboundmedicine.com/medline/citation/16402761/A_review_of_antioxidants_and_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -