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Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure.
Br J Dermatol 2006; 154(1):99-105BJ

Abstract

BACKGROUND

Mite allergen exposure is an important risk factor for specific IgE production and is associated with asthma, hay fever and eczema. Whether these associations are independent of mite species has not been investigated so far.

OBJECTIVES

To investigate the influence of exposure to the major house dust mite (HDM) allergens Der p 1 and Der f 1 on sensitization, respiratory symptoms, and especially on eczema and related skin symptoms in 6-7-year-old children.

METHODS

In a cross-sectional study in Augsburg (Bavaria, Germany) 1669 school beginners (mean age 6.5 years) were investigated in 1996. The concentrations of Der p 1 and Der f 1 were measured in dust samples from mattresses of 1081 children by enzyme-linked immunosorbent assay. The prevalence of atopy-related health outcomes was assessed by questionnaire, dermatological examination, skin prick testing and determination of specific serum IgE concentrations by radioallergosorbent test. Information about covariates was taken from questionnaires and interview data. Logistic regression was used to adjust for confounding.

RESULTS

The mean concentrations of Der p 1 and Der f 1 were 0.68 and 0.79 microg g(-1) dust, respectively. The relationship between the two species-specific allergens in individual homes was poor (Pearson correlation 0.2). Influencing variables were bedroom-sharing (Der p 1) and social status of the parents (Der f 1). Respiratory diseases were positively associated with both allergen concentrations [odds ratio (OR) between 1.1 and 2.6]. These associations were significant for sneezing attacks (Der p 1 and Der f 1). Reported prevalence of current (in the last 12 months) itchy skin rash was significantly associated with exposure to Der f 1 only (OR 2.4, P < 0.003); also a diagnosis of atopic eczema on the day of investigation was positively associated with Der f 1 only (OR 1.8, P = 0.14).

CONCLUSIONS

Studies on the effects of HDM exposure on eczema and allergies should consider specific effects of different mite species. This might have implications on assessment of allergen exposure and consecutive prevention or therapeutic measures.

Authors+Show Affiliations

Division of Environmental Dermatology and Allergy, National Research Centre for Environment and Health (GSF), Technical University Munich, Munich, Germany. krameru@uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16403101

Citation

Krämer, U, et al. "Current Eczema in Children Is Related to Der F 1 Exposure but Not to Der P 1 Exposure." The British Journal of Dermatology, vol. 154, no. 1, 2006, pp. 99-105.
Krämer U, Lemmen C, Bartusel E, et al. Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure. Br J Dermatol. 2006;154(1):99-105.
Krämer, U., Lemmen, C., Bartusel, E., Link, E., Ring, J., & Behrendt, H. (2006). Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure. The British Journal of Dermatology, 154(1), pp. 99-105.
Krämer U, et al. Current Eczema in Children Is Related to Der F 1 Exposure but Not to Der P 1 Exposure. Br J Dermatol. 2006;154(1):99-105. PubMed PMID: 16403101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure. AU - Krämer,U, AU - Lemmen,C, AU - Bartusel,E, AU - Link,E, AU - Ring,J, AU - Behrendt,H, PY - 2006/1/13/pubmed PY - 2006/5/31/medline PY - 2006/1/13/entrez SP - 99 EP - 105 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 154 IS - 1 N2 - BACKGROUND: Mite allergen exposure is an important risk factor for specific IgE production and is associated with asthma, hay fever and eczema. Whether these associations are independent of mite species has not been investigated so far. OBJECTIVES: To investigate the influence of exposure to the major house dust mite (HDM) allergens Der p 1 and Der f 1 on sensitization, respiratory symptoms, and especially on eczema and related skin symptoms in 6-7-year-old children. METHODS: In a cross-sectional study in Augsburg (Bavaria, Germany) 1669 school beginners (mean age 6.5 years) were investigated in 1996. The concentrations of Der p 1 and Der f 1 were measured in dust samples from mattresses of 1081 children by enzyme-linked immunosorbent assay. The prevalence of atopy-related health outcomes was assessed by questionnaire, dermatological examination, skin prick testing and determination of specific serum IgE concentrations by radioallergosorbent test. Information about covariates was taken from questionnaires and interview data. Logistic regression was used to adjust for confounding. RESULTS: The mean concentrations of Der p 1 and Der f 1 were 0.68 and 0.79 microg g(-1) dust, respectively. The relationship between the two species-specific allergens in individual homes was poor (Pearson correlation 0.2). Influencing variables were bedroom-sharing (Der p 1) and social status of the parents (Der f 1). Respiratory diseases were positively associated with both allergen concentrations [odds ratio (OR) between 1.1 and 2.6]. These associations were significant for sneezing attacks (Der p 1 and Der f 1). Reported prevalence of current (in the last 12 months) itchy skin rash was significantly associated with exposure to Der f 1 only (OR 2.4, P < 0.003); also a diagnosis of atopic eczema on the day of investigation was positively associated with Der f 1 only (OR 1.8, P = 0.14). CONCLUSIONS: Studies on the effects of HDM exposure on eczema and allergies should consider specific effects of different mite species. This might have implications on assessment of allergen exposure and consecutive prevention or therapeutic measures. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/16403101/Current_eczema_in_children_is_related_to_Der_f_1_exposure_but_not_to_Der_p_1_exposure_ L2 - https://doi.org/10.1111/j.1365-2133.2005.07003.x DB - PRIME DP - Unbound Medicine ER -