Tags

Type your tag names separated by a space and hit enter

Comparison of metabolic syndrome prevalence using six different definitions in overweight pre-pubertal children enrolled in a weight management study.
Int J Obes (Lond). 2006 May; 30(5):853-60.IJ

Abstract

OBJECTIVES

To assess the implications of variation in Metabolic Syndrome (MS) definition (biochemical and anthropometric indicators) on MS prevalence estimates in a population of overweight and mildly obese children.

DESIGN

Cross-sectional study.

SUBJECTS

Ninety-nine (64 girls) overweight or mildly obese, but otherwise healthy, pre-pubertal 6-9-year olds recruited for a randomized controlled trial of weight management.

MEASURES

Height, weight and waist circumference were measured with BMI and waist z-scores calculated. Fasting cholesterol and fractions, glucose and insulin were measured, together with systolic and diastolic blood pressure (BP). Anthropometric and metabolic indicators were classified as normal or elevated using adult- or child-specific cut points with clustering of MS indicators also assessed using two adult and three child-specific definitions.

RESULTS

A total of 0-4% of subjects were classified with MS when adult definitions were applied. This increased to between 39 and 60% using child-specific definitions, varying according to whether hyperinsulinaemia was central to the MS classification. Systolic BP, triglycerides, total cholesterol, high-density lipoprotein cholesterol and waist z-score increased across insulin quartiles (P<0.05). The use of body mass index and waist circumference in the MS definition classified the same subjects.

CONCLUSIONS

The classification of MS in children depends strongly on the definition chosen, with MS prevalence estimates higher if insulin is part of the definition and child-specific cut points for metabolic indicators are used. Hyperinsulinaemia and MS are common consequences of childhood obesity but they are not commonly part of the assessment or management plan for weight management in children. There is a need for the establishment of normal insulin ranges and consistent definition of MS in childhood and adolescence.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Flinders University, Adelaide, SA, Australia. gehl0002@flinders.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16404409

Citation

Golley, R K., et al. "Comparison of Metabolic Syndrome Prevalence Using Six Different Definitions in Overweight Pre-pubertal Children Enrolled in a Weight Management Study." International Journal of Obesity (2005), vol. 30, no. 5, 2006, pp. 853-60.
Golley RK, Magarey AM, Steinbeck KS, et al. Comparison of metabolic syndrome prevalence using six different definitions in overweight pre-pubertal children enrolled in a weight management study. Int J Obes (Lond). 2006;30(5):853-60.
Golley, R. K., Magarey, A. M., Steinbeck, K. S., Baur, L. A., & Daniels, L. A. (2006). Comparison of metabolic syndrome prevalence using six different definitions in overweight pre-pubertal children enrolled in a weight management study. International Journal of Obesity (2005), 30(5), 853-60.
Golley RK, et al. Comparison of Metabolic Syndrome Prevalence Using Six Different Definitions in Overweight Pre-pubertal Children Enrolled in a Weight Management Study. Int J Obes (Lond). 2006;30(5):853-60. PubMed PMID: 16404409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of metabolic syndrome prevalence using six different definitions in overweight pre-pubertal children enrolled in a weight management study. AU - Golley,R K, AU - Magarey,A M, AU - Steinbeck,K S, AU - Baur,L A, AU - Daniels,L A, PY - 2006/1/13/pubmed PY - 2006/12/13/medline PY - 2006/1/13/entrez SP - 853 EP - 60 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 5 N2 - OBJECTIVES: To assess the implications of variation in Metabolic Syndrome (MS) definition (biochemical and anthropometric indicators) on MS prevalence estimates in a population of overweight and mildly obese children. DESIGN: Cross-sectional study. SUBJECTS: Ninety-nine (64 girls) overweight or mildly obese, but otherwise healthy, pre-pubertal 6-9-year olds recruited for a randomized controlled trial of weight management. MEASURES: Height, weight and waist circumference were measured with BMI and waist z-scores calculated. Fasting cholesterol and fractions, glucose and insulin were measured, together with systolic and diastolic blood pressure (BP). Anthropometric and metabolic indicators were classified as normal or elevated using adult- or child-specific cut points with clustering of MS indicators also assessed using two adult and three child-specific definitions. RESULTS: A total of 0-4% of subjects were classified with MS when adult definitions were applied. This increased to between 39 and 60% using child-specific definitions, varying according to whether hyperinsulinaemia was central to the MS classification. Systolic BP, triglycerides, total cholesterol, high-density lipoprotein cholesterol and waist z-score increased across insulin quartiles (P<0.05). The use of body mass index and waist circumference in the MS definition classified the same subjects. CONCLUSIONS: The classification of MS in children depends strongly on the definition chosen, with MS prevalence estimates higher if insulin is part of the definition and child-specific cut points for metabolic indicators are used. Hyperinsulinaemia and MS are common consequences of childhood obesity but they are not commonly part of the assessment or management plan for weight management in children. There is a need for the establishment of normal insulin ranges and consistent definition of MS in childhood and adolescence. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16404409/Comparison_of_metabolic_syndrome_prevalence_using_six_different_definitions_in_overweight_pre_pubertal_children_enrolled_in_a_weight_management_study_ L2 - https://doi.org/10.1038/sj.ijo.0803195 DB - PRIME DP - Unbound Medicine ER -