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Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians.
Eur J Clin Nutr 2006; 60(6):791-801EJ

Abstract

OBJECTIVE

To assess the maternal sociodemographic, anthropometric, dietary and micronutrient status in apparently healthy pregnant women in order to determine their associations with intrauterine growth retardation (IUGR).

DESIGN

Prospective observational study.

SETTING

Bangalore City, India.

SUBJECTS

A total of 478 women were recruited at 12.9+/-3.3 weeks of gestation and followed up at the first, second and third trimesters of pregnancy and at delivery. The dropout rate was 8.5%.

INTERVENTIONS

None.

MAIN OUTCOME MEASURES

Birth weight was measured at hospital delivery.

RESULTS

The mean birth weight was 2.85+/-0.45 kg. In all, 28.6% of newborns were IUGR. There was a strong inverse relationship between maternal educational level and risk of IUGR. A low body weight at baseline was also associated with a high risk of IUGR. Compared with women in the highest quartile for second trimester weight gain, those in the lowest quartile had a significantly higher adjusted odds ratio (AOR: 3.98; 95% CI: 1.83, 8.65) for IUGR. Women in the lowest tertile for serum vitamin B(12) concentration during each of the three trimesters of pregnancy had significantly higher risk of IUGR (AOR: 5.98, 9.28 and 2.81 for trimesters 1-3, respectively).

CONCLUSIONS

The present study demonstrates associations between educational status, maternal weight and gestational weight gain with IUGR. Importantly, in a subsample, there were strong associations of vitamin B(12) status with IUGR, suggesting that better socioeconomic conditions, improved nutritional status and early detection of vitamin B(12) deficiency in pregnancy combined with appropriate interventions are likely to play an important role in reducing IUGR.

Authors+Show Affiliations

Division of Nutrition, Institute of Population Health and Clinical Research, St John's National Academy of Health Sciences, Bangalore, India. sumithra@phcr.res.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16404414

Citation

Muthayya, S, et al. "Low Maternal Vitamin B12 Status Is Associated With Intrauterine Growth Retardation in Urban South Indians." European Journal of Clinical Nutrition, vol. 60, no. 6, 2006, pp. 791-801.
Muthayya S, Kurpad AV, Duggan CP, et al. Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr. 2006;60(6):791-801.
Muthayya, S., Kurpad, A. V., Duggan, C. P., Bosch, R. J., Dwarkanath, P., Mhaskar, A., ... Fawzi, W. W. (2006). Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. European Journal of Clinical Nutrition, 60(6), pp. 791-801.
Muthayya S, et al. Low Maternal Vitamin B12 Status Is Associated With Intrauterine Growth Retardation in Urban South Indians. Eur J Clin Nutr. 2006;60(6):791-801. PubMed PMID: 16404414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. AU - Muthayya,S, AU - Kurpad,A V, AU - Duggan,C P, AU - Bosch,R J, AU - Dwarkanath,P, AU - Mhaskar,A, AU - Mhaskar,R, AU - Thomas,A, AU - Vaz,M, AU - Bhat,S, AU - Fawzi,W W, Y1 - 2006/01/11/ PY - 2006/1/13/pubmed PY - 2006/10/25/medline PY - 2006/1/13/entrez SP - 791 EP - 801 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 6 N2 - OBJECTIVE: To assess the maternal sociodemographic, anthropometric, dietary and micronutrient status in apparently healthy pregnant women in order to determine their associations with intrauterine growth retardation (IUGR). DESIGN: Prospective observational study. SETTING: Bangalore City, India. SUBJECTS: A total of 478 women were recruited at 12.9+/-3.3 weeks of gestation and followed up at the first, second and third trimesters of pregnancy and at delivery. The dropout rate was 8.5%. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Birth weight was measured at hospital delivery. RESULTS: The mean birth weight was 2.85+/-0.45 kg. In all, 28.6% of newborns were IUGR. There was a strong inverse relationship between maternal educational level and risk of IUGR. A low body weight at baseline was also associated with a high risk of IUGR. Compared with women in the highest quartile for second trimester weight gain, those in the lowest quartile had a significantly higher adjusted odds ratio (AOR: 3.98; 95% CI: 1.83, 8.65) for IUGR. Women in the lowest tertile for serum vitamin B(12) concentration during each of the three trimesters of pregnancy had significantly higher risk of IUGR (AOR: 5.98, 9.28 and 2.81 for trimesters 1-3, respectively). CONCLUSIONS: The present study demonstrates associations between educational status, maternal weight and gestational weight gain with IUGR. Importantly, in a subsample, there were strong associations of vitamin B(12) status with IUGR, suggesting that better socioeconomic conditions, improved nutritional status and early detection of vitamin B(12) deficiency in pregnancy combined with appropriate interventions are likely to play an important role in reducing IUGR. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16404414/Low_maternal_vitamin_B12_status_is_associated_with_intrauterine_growth_retardation_in_urban_South_Indians_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602383 DB - PRIME DP - Unbound Medicine ER -