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Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols.
Eur J Clin Nutr. 2006 May; 60(5):633-42.EJ

Abstract

OBJECTIVE

The aim of this study was to investigate whether a plant sterol mixture would reduce serum cholesterol when added to low fat dairy products in subjects with hypercholesterolaemia, and to examine the effects of the mixture on the serum plant sterol and fat-soluble vitamin levels.

DESIGN

A parallel, double-blind study.

SETTING

The study was performed in three different locations in Finland.

SUBJECTS

In total, 164 mildly or moderately hypercholesterolaemic subjects participated in the study.

METHODS

The subjects were randomly divided into two groups: a plant sterol group and a control group. The subjects consumed the products for 6 weeks after a 3-week run-in period. The targeted plant sterol intake was 2 g/day in the sterol group.

RESULTS

During the treatment period, there was a 6.5% reduction in serum total cholesterol in the sterol group while no change was observed in the control group (P<0.0005). Serum low-density lipoprotein (LDL) cholesterol was reduced by 10.4% in the sterol group and by 0.6% in the control group (P<0.00005). There was no change during the trial in serum high-density lipoprotein (HDL) cholesterol or triacylglycerol concentrations. The HDL/LDL cholesterol ratio increased by 16.1% in the sterol group and by 4.3% in the control group (P=0.0001). Serum plant sterol levels increased significantly (P=0.0001) in the sterol group. None of the fat-soluble vitamin levels decreased significantly when changes in serum total cholesterol were taken into account. The hypocholesterolaemic effect of sterol administration was not influenced by apolipoprotein E phenotype.

CONCLUSIONS

Yoghurt, low-fat hard cheese and low-fat fresh cheese enriched with a plant sterol mixture reduced serum cholesterol in hypercholesterolaemic subjects and no adverse effects were noted in the dietary control of hypercholesterolaemia.

Authors+Show Affiliations

Foundation for Nutrition Research, Helsinki, Finland. riitta.korpela@valio.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16404415

Citation

Korpela, R, et al. "Safety Aspects and Cholesterol-lowering Efficacy of Low Fat Dairy Products Containing Plant Sterols." European Journal of Clinical Nutrition, vol. 60, no. 5, 2006, pp. 633-42.
Korpela R, Tuomilehto J, Högström P, et al. Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols. Eur J Clin Nutr. 2006;60(5):633-42.
Korpela, R., Tuomilehto, J., Högström, P., Seppo, L., Piironen, V., Salo-Väänänen, P., Toivo, J., Lamberg-Allardt, C., Kärkkäinen, M., Outila, T., Sundvall, J., Vilkkilä, S., & Tikkanen, M. J. (2006). Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols. European Journal of Clinical Nutrition, 60(5), 633-42.
Korpela R, et al. Safety Aspects and Cholesterol-lowering Efficacy of Low Fat Dairy Products Containing Plant Sterols. Eur J Clin Nutr. 2006;60(5):633-42. PubMed PMID: 16404415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols. AU - Korpela,R, AU - Tuomilehto,J, AU - Högström,P, AU - Seppo,L, AU - Piironen,V, AU - Salo-Väänänen,P, AU - Toivo,J, AU - Lamberg-Allardt,C, AU - Kärkkäinen,M, AU - Outila,T, AU - Sundvall,J, AU - Vilkkilä,S, AU - Tikkanen,M J, PY - 2006/1/13/pubmed PY - 2006/6/9/medline PY - 2006/1/13/entrez SP - 633 EP - 42 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 5 N2 - OBJECTIVE: The aim of this study was to investigate whether a plant sterol mixture would reduce serum cholesterol when added to low fat dairy products in subjects with hypercholesterolaemia, and to examine the effects of the mixture on the serum plant sterol and fat-soluble vitamin levels. DESIGN: A parallel, double-blind study. SETTING: The study was performed in three different locations in Finland. SUBJECTS: In total, 164 mildly or moderately hypercholesterolaemic subjects participated in the study. METHODS: The subjects were randomly divided into two groups: a plant sterol group and a control group. The subjects consumed the products for 6 weeks after a 3-week run-in period. The targeted plant sterol intake was 2 g/day in the sterol group. RESULTS: During the treatment period, there was a 6.5% reduction in serum total cholesterol in the sterol group while no change was observed in the control group (P<0.0005). Serum low-density lipoprotein (LDL) cholesterol was reduced by 10.4% in the sterol group and by 0.6% in the control group (P<0.00005). There was no change during the trial in serum high-density lipoprotein (HDL) cholesterol or triacylglycerol concentrations. The HDL/LDL cholesterol ratio increased by 16.1% in the sterol group and by 4.3% in the control group (P=0.0001). Serum plant sterol levels increased significantly (P=0.0001) in the sterol group. None of the fat-soluble vitamin levels decreased significantly when changes in serum total cholesterol were taken into account. The hypocholesterolaemic effect of sterol administration was not influenced by apolipoprotein E phenotype. CONCLUSIONS: Yoghurt, low-fat hard cheese and low-fat fresh cheese enriched with a plant sterol mixture reduced serum cholesterol in hypercholesterolaemic subjects and no adverse effects were noted in the dietary control of hypercholesterolaemia. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16404415/Safety_aspects_and_cholesterol_lowering_efficacy_of_low_fat_dairy_products_containing_plant_sterols_ L2 - https://doi.org/10.1038/sj.ejcn.1602362 DB - PRIME DP - Unbound Medicine ER -