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Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols.
Mol Nutr Food Res. 2006 Feb; 50(2):211-7.MN

Abstract

Among the health-promoting effects of tea and tea polyphenols, the cancer-chemopreventive effects in various animal model systems have been intensively investigated; meanwhile, the hypolipidemic and antiobesity effects in animals and humans have also become a hot issue for molecular nutrition and food research. It has been demonstrated that the body weights of rats and their plasma triglyceride, cholesterol, and LDL-cholesterol have been significantly reduced by feedings of oolong, black, pu-erh, and green tea leaves to the animals. It has been suggested that the inhibition of growth and suppression of lipogenesis in MCF-7 breast cancer cells may be through down-regulation of fatty acid synthase gene expression in the nucleus and stimulation of cell energy expenditure in the mitochondria. The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways.

Authors+Show Affiliations

Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan. jklin@ha.mc.ntu.edu.twNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16404708

Citation

Lin, Jen-Kun, and Shoei-Yn Lin-Shiau. "Mechanisms of Hypolipidemic and Anti-obesity Effects of Tea and Tea Polyphenols." Molecular Nutrition & Food Research, vol. 50, no. 2, 2006, pp. 211-7.
Lin JK, Lin-Shiau SY. Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol Nutr Food Res. 2006;50(2):211-7.
Lin, J. K., & Lin-Shiau, S. Y. (2006). Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Molecular Nutrition & Food Research, 50(2), 211-7.
Lin JK, Lin-Shiau SY. Mechanisms of Hypolipidemic and Anti-obesity Effects of Tea and Tea Polyphenols. Mol Nutr Food Res. 2006;50(2):211-7. PubMed PMID: 16404708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. AU - Lin,Jen-Kun, AU - Lin-Shiau,Shoei-Yn, PY - 2006/1/13/pubmed PY - 2006/4/28/medline PY - 2006/1/13/entrez SP - 211 EP - 7 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 50 IS - 2 N2 - Among the health-promoting effects of tea and tea polyphenols, the cancer-chemopreventive effects in various animal model systems have been intensively investigated; meanwhile, the hypolipidemic and antiobesity effects in animals and humans have also become a hot issue for molecular nutrition and food research. It has been demonstrated that the body weights of rats and their plasma triglyceride, cholesterol, and LDL-cholesterol have been significantly reduced by feedings of oolong, black, pu-erh, and green tea leaves to the animals. It has been suggested that the inhibition of growth and suppression of lipogenesis in MCF-7 breast cancer cells may be through down-regulation of fatty acid synthase gene expression in the nucleus and stimulation of cell energy expenditure in the mitochondria. The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/16404708/Mechanisms_of_hypolipidemic_and_anti_obesity_effects_of_tea_and_tea_polyphenols_ L2 - https://doi.org/10.1002/mnfr.200500138 DB - PRIME DP - Unbound Medicine ER -