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Abdominal pain impacts quality of life in women with irritable bowel syndrome.
Am J Gastroenterol 2006; 101(1):124-32AJ

Abstract

OBJECTIVES

Patients with irritable bowel syndrome (IBS) report lower health-related quality of life (QoL) as compared to healthy controls. The aims of this analysis were to describe which IBS symptoms were rated on a daily diary as most distressing/severe by IBS women, and determine which IBS symptoms were most predictive of lower QoL and have the greatest impact on daily life.

METHODS

This report is a secondary analysis of prospective and retrospective symptom severity and impact data, collected on 242 women with IBS, aged 18-48, who were studied between 1997 and 2004.

RESULTS

On the daily diary, intestinal gas was the most frequent IBS symptom with subjects reporting at least minimal intestinal gas on 74% of days and moderate or worse severity on 27% of days. Abdominal pain occurred at least minimally on 62% of days. Diarrhea was the least common. Across women, abdominal pain was most strongly related to life impact variables and QoL, followed by intestinal gas and bloating. Analysis of day-to-day variation within women showed that abdominal pain was most strongly correlated with daily life impact variables and constipation had the weakest correlation. While diarrhea had a lower correlation with life impact, this was due to the low prevalence of diarrhea. When it occurs, diarrhea has a large impact. Partial correlation analysis showed that the impact of diarrhea is independent of abdominal pain.

CONCLUSION

Abdominal pain is the most disruptive IBS symptom. Diarrhea also has an independent and significant impact when it occurs, especially in those with diarrhea-predominant IBS.

Authors+Show Affiliations

Office for Nursing Research and Department of Biostatistics, University of Washington, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16405544

Citation

Cain, Kevin C., et al. "Abdominal Pain Impacts Quality of Life in Women With Irritable Bowel Syndrome." The American Journal of Gastroenterology, vol. 101, no. 1, 2006, pp. 124-32.
Cain KC, Headstrom P, Jarrett ME, et al. Abdominal pain impacts quality of life in women with irritable bowel syndrome. Am J Gastroenterol. 2006;101(1):124-32.
Cain, K. C., Headstrom, P., Jarrett, M. E., Motzer, S. A., Park, H., Burr, R. L., ... Heitkemper, M. M. (2006). Abdominal pain impacts quality of life in women with irritable bowel syndrome. The American Journal of Gastroenterology, 101(1), pp. 124-32.
Cain KC, et al. Abdominal Pain Impacts Quality of Life in Women With Irritable Bowel Syndrome. Am J Gastroenterol. 2006;101(1):124-32. PubMed PMID: 16405544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abdominal pain impacts quality of life in women with irritable bowel syndrome. AU - Cain,Kevin C, AU - Headstrom,Peggy, AU - Jarrett,Monica E, AU - Motzer,Sandra A, AU - Park,Hyojung, AU - Burr,Robert L, AU - Surawicz,Christine M, AU - Heitkemper,Margaret M, PY - 2006/1/13/pubmed PY - 2006/3/8/medline PY - 2006/1/13/entrez SP - 124 EP - 32 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 101 IS - 1 N2 - OBJECTIVES: Patients with irritable bowel syndrome (IBS) report lower health-related quality of life (QoL) as compared to healthy controls. The aims of this analysis were to describe which IBS symptoms were rated on a daily diary as most distressing/severe by IBS women, and determine which IBS symptoms were most predictive of lower QoL and have the greatest impact on daily life. METHODS: This report is a secondary analysis of prospective and retrospective symptom severity and impact data, collected on 242 women with IBS, aged 18-48, who were studied between 1997 and 2004. RESULTS: On the daily diary, intestinal gas was the most frequent IBS symptom with subjects reporting at least minimal intestinal gas on 74% of days and moderate or worse severity on 27% of days. Abdominal pain occurred at least minimally on 62% of days. Diarrhea was the least common. Across women, abdominal pain was most strongly related to life impact variables and QoL, followed by intestinal gas and bloating. Analysis of day-to-day variation within women showed that abdominal pain was most strongly correlated with daily life impact variables and constipation had the weakest correlation. While diarrhea had a lower correlation with life impact, this was due to the low prevalence of diarrhea. When it occurs, diarrhea has a large impact. Partial correlation analysis showed that the impact of diarrhea is independent of abdominal pain. CONCLUSION: Abdominal pain is the most disruptive IBS symptom. Diarrhea also has an independent and significant impact when it occurs, especially in those with diarrhea-predominant IBS. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/16405544/Abdominal_pain_impacts_quality_of_life_in_women_with_irritable_bowel_syndrome_ L2 - http://Insights.ovid.com/pubmed?pmid=16405544 DB - PRIME DP - Unbound Medicine ER -