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Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis.

Abstract

Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-gamma secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.

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  • Authors+Show Affiliations

    ,

    Section of Infectious Disease, Department of Internal Medicine, Korea University Medical College, Korea University Guro Hospital, 97 Guro Dong-Gil, Guro Gu, Seoul 152-703, South Korea. heejinmd@medimail.co.kr

    , , , , , , ,

    Source

    Vaccine 24:13 2006 Mar 20 pg 2417-22

    MeSH

    Antibodies, Viral
    Female
    Humans
    Influenza A Virus, H1N1 Subtype
    Influenza A Virus, H3N2 Subtype
    Influenza Vaccines
    Interferon-gamma
    Liver Cirrhosis
    Male
    Middle Aged
    Vaccination

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16406176

    Citation

    Cheong, Hee-Jin, et al. "Humoral and Cellular Immune Responses to Influenza Vaccine in Patients With Advanced Cirrhosis." Vaccine, vol. 24, no. 13, 2006, pp. 2417-22.
    Cheong HJ, Song JY, Park JW, et al. Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis. Vaccine. 2006;24(13):2417-22.
    Cheong, H. J., Song, J. Y., Park, J. W., Yeon, J. E., Byun, K. S., Lee, C. H., ... Kim, W. J. (2006). Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis. Vaccine, 24(13), pp. 2417-22.
    Cheong HJ, et al. Humoral and Cellular Immune Responses to Influenza Vaccine in Patients With Advanced Cirrhosis. Vaccine. 2006 Mar 20;24(13):2417-22. PubMed PMID: 16406176.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis. AU - Cheong,Hee-Jin, AU - Song,Joon-Young, AU - Park,Jeong-Won, AU - Yeon,Jong-Eun, AU - Byun,Kwan-Soo, AU - Lee,Chang-Hong, AU - Cho,Hyun-Il, AU - Kim,Tai-Gyu, AU - Kim,Woo-Joo, Y1 - 2005/12/19/ PY - 2005/02/07/received PY - 2005/11/23/revised PY - 2005/11/28/accepted PY - 2006/1/13/pubmed PY - 2006/5/26/medline PY - 2006/1/13/entrez SP - 2417 EP - 22 JF - Vaccine JO - Vaccine VL - 24 IS - 13 N2 - Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-gamma secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/16406176/Humoral_and_cellular_immune_responses_to_influenza_vaccine_in_patients_with_advanced_cirrhosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(05)01210-7 DB - PRIME DP - Unbound Medicine ER -