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Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory.
Neurosci Lett. 2006 Mar 20; 396(1):23-7.NL

Abstract

Apolipoprotein E epsilon4 (APOE epsilon4) is the main known genetic risk factor for Alzheimer's disease (AD). Some previous studies have reported structural brain changes as well as cognitive deficits in non-demented APOE epsilon4 carriers, but the pattern of results is inconsistent and studies with larger sample sizes have been called for. Here we compared hippocampal volume and recognition-memory performance between AD-symptom-free carriers (N=30) and non-carriers (N=30) of the APOE epsilon4 (age range: 49-79 years). We observed reduced right hippocampal volume in APOE epsilon4 carriers, and found that the difference was most pronounced before the age of 65. Further, the APOE epsilon4 carriers made significantly more false alarms in the recognition-memory test, and the number of false alarms correlated significantly with right hippocampus volume. These results indicate that relatively young individuals at genetic risk for AD have smaller hippocampal volume and lower performance on hippocampal-dependent cognitive tasks. A question for the future is whether smaller hippocampal volume represents early-onset hippocampal volume reduction or an inherent trait.

Authors+Show Affiliations

Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N-8, S-171 76 Stockholm, Sweden. johanna.lind@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16406347

Citation

Lind, Johanna, et al. "Reduced Hippocampal Volume in Non-demented Carriers of the Apolipoprotein E Epsilon4: Relation to Chronological Age and Recognition Memory." Neuroscience Letters, vol. 396, no. 1, 2006, pp. 23-7.
Lind J, Larsson A, Persson J, et al. Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory. Neurosci Lett. 2006;396(1):23-7.
Lind, J., Larsson, A., Persson, J., Ingvar, M., Nilsson, L. G., Bäckman, L., Adolfsson, R., Cruts, M., Sleegers, K., Van Broeckhoven, C., & Nyberg, L. (2006). Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory. Neuroscience Letters, 396(1), 23-7.
Lind J, et al. Reduced Hippocampal Volume in Non-demented Carriers of the Apolipoprotein E Epsilon4: Relation to Chronological Age and Recognition Memory. Neurosci Lett. 2006 Mar 20;396(1):23-7. PubMed PMID: 16406347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory. AU - Lind,Johanna, AU - Larsson,Anne, AU - Persson,Jonas, AU - Ingvar,Martin, AU - Nilsson,Lars-Göran, AU - Bäckman,Lars, AU - Adolfsson,Rolf, AU - Cruts,Marc, AU - Sleegers,Kristel, AU - Van Broeckhoven,Christine, AU - Nyberg,Lars, Y1 - 2006/01/06/ PY - 2005/09/15/received PY - 2005/11/03/revised PY - 2005/11/07/accepted PY - 2006/1/13/pubmed PY - 2006/4/29/medline PY - 2006/1/13/entrez SP - 23 EP - 7 JF - Neuroscience letters JO - Neurosci. Lett. VL - 396 IS - 1 N2 - Apolipoprotein E epsilon4 (APOE epsilon4) is the main known genetic risk factor for Alzheimer's disease (AD). Some previous studies have reported structural brain changes as well as cognitive deficits in non-demented APOE epsilon4 carriers, but the pattern of results is inconsistent and studies with larger sample sizes have been called for. Here we compared hippocampal volume and recognition-memory performance between AD-symptom-free carriers (N=30) and non-carriers (N=30) of the APOE epsilon4 (age range: 49-79 years). We observed reduced right hippocampal volume in APOE epsilon4 carriers, and found that the difference was most pronounced before the age of 65. Further, the APOE epsilon4 carriers made significantly more false alarms in the recognition-memory test, and the number of false alarms correlated significantly with right hippocampus volume. These results indicate that relatively young individuals at genetic risk for AD have smaller hippocampal volume and lower performance on hippocampal-dependent cognitive tasks. A question for the future is whether smaller hippocampal volume represents early-onset hippocampal volume reduction or an inherent trait. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16406347/Reduced_hippocampal_volume_in_non_demented_carriers_of_the_apolipoprotein_E_epsilon4:_relation_to_chronological_age_and_recognition_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(05)01379-0 DB - PRIME DP - Unbound Medicine ER -