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Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat.
J Ethnopharmacol. 2006 May 24; 105(3):415-20.JE

Abstract

Larrea divaricata Cav. (Zygophyllaceae) is used in popular medicine as anti-inflammatory and anti-rheumatic drug, containing higher amounts of nordihydroguaiaretic acid, a well-known free radical scavenger. Here we describe the gastric anti-ulcerogenic effect of the methanolic extract of Larrea divaricata (LdME) leaves in rat, using absolute ethanol and HCl 0.6N as necrotizing agents, and the effect of blocking endogenous sulfhydryl (SH) groups with N-ethylmaleimide (NEM). We also studied the anti-inflammatory activity of LdME in two rat experimental models: cotton pellet induced granuloma and arthritis induced by adjuvant-carrageenan. Influence of treatment in body weight and some lymphoid organs was evaluated. Finally, the free radical scavenging capacity of LdME was determined by the method of 1,1-diphenyl-2-picrylhydrazyl (DPPH) inhibition. LdME demonstrated anti-ulcerogenic effect in rats, and it was shown that the endogenous SH compounds were not involved in the mechanism of action. LdME also showed inhibitory activity in the applied models of inflammation, being more effective in the acute phase. No effect was observed concerning the weight of spleen, thymus and body. The extract proved to possess elevated free radical scavenging capacity which may contribute to the observed gastric anti-ulcerogenic and anti-inflammatory activity.

Authors+Show Affiliations

Cátedra de Farmacología, Departamento de Farmacia, Facultad de Química, Bioquímica y Farmacia, Chacabuco y Pedernera, 5700 San Luis, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16406415

Citation

Pedernera, Ana María, et al. "Anti-ulcerogenic and Anti-inflammatory Activity of the Methanolic Extract of Larrea Divaricata Cav. in Rat." Journal of Ethnopharmacology, vol. 105, no. 3, 2006, pp. 415-20.
Pedernera AM, Guardia T, Calderón CG, et al. Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. J Ethnopharmacol. 2006;105(3):415-20.
Pedernera, A. M., Guardia, T., Calderón, C. G., Rotelli, A. E., de la Rocha, N. E., Genaro, S. D., & Pelzer, L. E. (2006). Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. Journal of Ethnopharmacology, 105(3), 415-20.
Pedernera AM, et al. Anti-ulcerogenic and Anti-inflammatory Activity of the Methanolic Extract of Larrea Divaricata Cav. in Rat. J Ethnopharmacol. 2006 May 24;105(3):415-20. PubMed PMID: 16406415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. AU - Pedernera,Ana María, AU - Guardia,Teresita, AU - Calderón,Carola Guardia, AU - Rotelli,Alejandra Ester, AU - de la Rocha,Nadir Ernesto, AU - Genaro,Silvia Di, AU - Pelzer,Lilian Eugenia, Y1 - 2006/01/06/ PY - 2004/08/31/received PY - 2005/11/21/revised PY - 2005/11/23/accepted PY - 2006/1/13/pubmed PY - 2006/12/9/medline PY - 2006/1/13/entrez SP - 415 EP - 20 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 105 IS - 3 N2 - Larrea divaricata Cav. (Zygophyllaceae) is used in popular medicine as anti-inflammatory and anti-rheumatic drug, containing higher amounts of nordihydroguaiaretic acid, a well-known free radical scavenger. Here we describe the gastric anti-ulcerogenic effect of the methanolic extract of Larrea divaricata (LdME) leaves in rat, using absolute ethanol and HCl 0.6N as necrotizing agents, and the effect of blocking endogenous sulfhydryl (SH) groups with N-ethylmaleimide (NEM). We also studied the anti-inflammatory activity of LdME in two rat experimental models: cotton pellet induced granuloma and arthritis induced by adjuvant-carrageenan. Influence of treatment in body weight and some lymphoid organs was evaluated. Finally, the free radical scavenging capacity of LdME was determined by the method of 1,1-diphenyl-2-picrylhydrazyl (DPPH) inhibition. LdME demonstrated anti-ulcerogenic effect in rats, and it was shown that the endogenous SH compounds were not involved in the mechanism of action. LdME also showed inhibitory activity in the applied models of inflammation, being more effective in the acute phase. No effect was observed concerning the weight of spleen, thymus and body. The extract proved to possess elevated free radical scavenging capacity which may contribute to the observed gastric anti-ulcerogenic and anti-inflammatory activity. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16406415/Anti_ulcerogenic_and_anti_inflammatory_activity_of_the_methanolic_extract_of_Larrea_divaricata_Cav__in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00789-0 DB - PRIME DP - Unbound Medicine ER -