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Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis.
Bone 2006; 38(5):686-93BONE

Abstract

Soy protein is reported to prevent bone loss in both women and rat models of osteoporosis. However, the role of soy isoflavones on the trabecular microarchitectural properties needs to be explored. In the present study, we examined whether soy protein with graded doses of isoflavones reverses loss of bone mineral density (BMD), bone mineral content (BMC), and trabecular microstructure in an ovariectomized (Ovx) osteopenic rat model. Seventy-eight 9-m old female Sprague-Dawley rats were either sham-operated (Sham; 1 group) or Ovx (5 groups) and fed a semi-purified casein-based diet. After 90 days, the occurrence of bone loss was confirmed using dual energy X-ray absorptiometry. Thereafter, rats were assigned to the following treatments: Sham, Ovx (control), Ovx + 17beta-estradiol (E(2); 10 microg/kg body wt. twice per week), Ovx + soy protein depleted of isoflavones (Soy-; 0.06 mg isoflavones/g protein), Ovx + soy protein with normal isoflavone content (Soy; 3.55 mg isoflavones/g protein), and Ovx + isoflavone-enriched soy protein (Soy+; 7.10 mg isoflavones/g protein). After 125 days of treatment, rats were euthanized, and tibia and lumbar bones were collected for the assessment of BMD, BMC, and trabecular microarchitectural properties using X-ray microcomputed tomography. None of the treatments had an effect on BMD or microarchitectural properties of the lumbar vertebra. However, Soy treatment significantly increased tibial BMC and BMD by 10% and 4.5% compared with Ovx control, but the increase in BMD was not enough to reach the BMD levels of the Sham control group. The Soy+ diet positively affected the tibial architectural properties including trabecular thickness, separation, and number. In summary, our findings suggest that soy protein does not restore bone loss in osteopenic rats; however, higher doses of isoflavones may be required to reverse the loss of tibial microstructural properties.

Authors+Show Affiliations

Department of Nutritional Sciences, Oklahoma State University, 301 Human Environmental Sciences, Stillwater, OK 74078-6141, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16406762

Citation

Devareddy, Latha, et al. "Soy Moderately Improves Microstructural Properties Without Affecting Bone Mass in an Ovariectomized Rat Model of Osteoporosis." Bone, vol. 38, no. 5, 2006, pp. 686-93.
Devareddy L, Khalil DA, Smith BJ, et al. Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. Bone. 2006;38(5):686-93.
Devareddy, L., Khalil, D. A., Smith, B. J., Lucas, E. A., Soung, d. o. . Y., Marlow, D. D., & Arjmandi, B. H. (2006). Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. Bone, 38(5), pp. 686-93.
Devareddy L, et al. Soy Moderately Improves Microstructural Properties Without Affecting Bone Mass in an Ovariectomized Rat Model of Osteoporosis. Bone. 2006;38(5):686-93. PubMed PMID: 16406762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. AU - Devareddy,Latha, AU - Khalil,Dania A, AU - Smith,Brenda J, AU - Lucas,Edralin A, AU - Soung,Do Y, AU - Marlow,Denver D, AU - Arjmandi,Bahram H, Y1 - 2006/01/10/ PY - 2004/07/29/received PY - 2005/09/19/revised PY - 2005/10/13/accepted PY - 2006/1/13/pubmed PY - 2006/7/29/medline PY - 2006/1/13/entrez SP - 686 EP - 93 JF - Bone JO - Bone VL - 38 IS - 5 N2 - Soy protein is reported to prevent bone loss in both women and rat models of osteoporosis. However, the role of soy isoflavones on the trabecular microarchitectural properties needs to be explored. In the present study, we examined whether soy protein with graded doses of isoflavones reverses loss of bone mineral density (BMD), bone mineral content (BMC), and trabecular microstructure in an ovariectomized (Ovx) osteopenic rat model. Seventy-eight 9-m old female Sprague-Dawley rats were either sham-operated (Sham; 1 group) or Ovx (5 groups) and fed a semi-purified casein-based diet. After 90 days, the occurrence of bone loss was confirmed using dual energy X-ray absorptiometry. Thereafter, rats were assigned to the following treatments: Sham, Ovx (control), Ovx + 17beta-estradiol (E(2); 10 microg/kg body wt. twice per week), Ovx + soy protein depleted of isoflavones (Soy-; 0.06 mg isoflavones/g protein), Ovx + soy protein with normal isoflavone content (Soy; 3.55 mg isoflavones/g protein), and Ovx + isoflavone-enriched soy protein (Soy+; 7.10 mg isoflavones/g protein). After 125 days of treatment, rats were euthanized, and tibia and lumbar bones were collected for the assessment of BMD, BMC, and trabecular microarchitectural properties using X-ray microcomputed tomography. None of the treatments had an effect on BMD or microarchitectural properties of the lumbar vertebra. However, Soy treatment significantly increased tibial BMC and BMD by 10% and 4.5% compared with Ovx control, but the increase in BMD was not enough to reach the BMD levels of the Sham control group. The Soy+ diet positively affected the tibial architectural properties including trabecular thickness, separation, and number. In summary, our findings suggest that soy protein does not restore bone loss in osteopenic rats; however, higher doses of isoflavones may be required to reverse the loss of tibial microstructural properties. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/16406762/Soy_moderately_improves_microstructural_properties_without_affecting_bone_mass_in_an_ovariectomized_rat_model_of_osteoporosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(05)00424-2 DB - PRIME DP - Unbound Medicine ER -