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Association between an estrogen receptor alpha gene polymorphism and the risk of prostate cancer in black men.
J Urol. 2006 Feb; 175(2):523-7.JU

Abstract

PURPOSE

Studies suggest that SNPs within ESR1 may be associated with an increased risk of prostate cancer. We evaluated the association of the XbaI and PvuII ESR1 SNPs and prostate cancer risk in 3 different racial/ethnic populations.

MATERIALS AND METHODS

A total of 1,603 volunteers from the SABOR study (285 black, 876 white and 442 Hispanic men) were genotyped to assess allelic frequencies of the ESR1 SNPs. Case-control analysis was performed on 598 prostate cancer cases and 1,098 controls (260 black men, 1,013 non-Hispanic white men and 423 Hispanic white men) to assess the association between these polymorphisms and prostate cancer risk.

RESULTS

Allelic frequency was significantly different across ethnic/racial groups for both SNPs. Logistic regression analysis adjusted for age and stratified by race and ethnicity demonstrated an association between the AG genotype or presence of the G allele (GG or AG genotype) in the XbaI SNP and prostate cancer risk within black men (OR 2.25, 95% CI 1.07-4.70, p = 0.031; OR 2.14, 95% CI 1.05-4.35, p = 0.035, respectively). No association was observed among Hispanic and non-Hispanic white men for this SNP. Furthermore, there was no association between the PvuII SNP and prostate cancer risk across all groups.

CONCLUSIONS

Our study demonstrates an association between the AG genotype, as well as presence of the G allele within the XbaI ESR1 SNP and prostate cancer risk among black men.

Authors+Show Affiliations

Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16406987

Citation

Hernández, Javier, et al. "Association Between an Estrogen Receptor Alpha Gene Polymorphism and the Risk of Prostate Cancer in Black Men." The Journal of Urology, vol. 175, no. 2, 2006, pp. 523-7.
Hernández J, Balic I, Johnson-Pais TL, et al. Association between an estrogen receptor alpha gene polymorphism and the risk of prostate cancer in black men. J Urol. 2006;175(2):523-7.
Hernández, J., Balic, I., Johnson-Pais, T. L., Higgins, B. A., Torkko, K. C., Thompson, I. M., & Leach, R. J. (2006). Association between an estrogen receptor alpha gene polymorphism and the risk of prostate cancer in black men. The Journal of Urology, 175(2), 523-7.
Hernández J, et al. Association Between an Estrogen Receptor Alpha Gene Polymorphism and the Risk of Prostate Cancer in Black Men. J Urol. 2006;175(2):523-7. PubMed PMID: 16406987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between an estrogen receptor alpha gene polymorphism and the risk of prostate cancer in black men. AU - Hernández,Javier, AU - Balic,Ivana, AU - Johnson-Pais,Teresa L, AU - Higgins,Betsy A, AU - Torkko,Kathleen C, AU - Thompson,Ian M, AU - Leach,Robin J, PY - 2005/03/04/received PY - 2006/1/13/pubmed PY - 2006/2/28/medline PY - 2006/1/13/entrez SP - 523 EP - 7 JF - The Journal of urology JO - J Urol VL - 175 IS - 2 N2 - PURPOSE: Studies suggest that SNPs within ESR1 may be associated with an increased risk of prostate cancer. We evaluated the association of the XbaI and PvuII ESR1 SNPs and prostate cancer risk in 3 different racial/ethnic populations. MATERIALS AND METHODS: A total of 1,603 volunteers from the SABOR study (285 black, 876 white and 442 Hispanic men) were genotyped to assess allelic frequencies of the ESR1 SNPs. Case-control analysis was performed on 598 prostate cancer cases and 1,098 controls (260 black men, 1,013 non-Hispanic white men and 423 Hispanic white men) to assess the association between these polymorphisms and prostate cancer risk. RESULTS: Allelic frequency was significantly different across ethnic/racial groups for both SNPs. Logistic regression analysis adjusted for age and stratified by race and ethnicity demonstrated an association between the AG genotype or presence of the G allele (GG or AG genotype) in the XbaI SNP and prostate cancer risk within black men (OR 2.25, 95% CI 1.07-4.70, p = 0.031; OR 2.14, 95% CI 1.05-4.35, p = 0.035, respectively). No association was observed among Hispanic and non-Hispanic white men for this SNP. Furthermore, there was no association between the PvuII SNP and prostate cancer risk across all groups. CONCLUSIONS: Our study demonstrates an association between the AG genotype, as well as presence of the G allele within the XbaI ESR1 SNP and prostate cancer risk among black men. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/16406987/Association_between_an_estrogen_receptor_alpha_gene_polymorphism_and_the_risk_of_prostate_cancer_in_black_men_ L2 - https://www.jurology.com/doi/10.1016/S0022-5347(05)00240-5?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -