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Iron imports. IV. Hepcidin and regulation of body iron metabolism.
Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G199-203.AJ

Abstract

Hepcidin, a small peptide synthesized in the liver, controls extracellular iron by regulating its intestinal absorption, placental transport, recycling by macrophages, and release from stores. Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin, the sole iron exporter in iron-transporting cells. In turn, hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia. Hepcidin is markedly induced during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations, and contributing to the anemia of inflammation. Hepcidin deficiency due to the dysregulation of its synthesis causes most known forms of hemochromatosis.

Authors+Show Affiliations

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1690, USA. tganz@mednet.ucla.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16407589

Citation

Ganz, Tomas, and Elizabeta Nemeth. "Iron Imports. IV. Hepcidin and Regulation of Body Iron Metabolism." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 290, no. 2, 2006, pp. G199-203.
Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290(2):G199-203.
Ganz, T., & Nemeth, E. (2006). Iron imports. IV. Hepcidin and regulation of body iron metabolism. American Journal of Physiology. Gastrointestinal and Liver Physiology, 290(2), G199-203.
Ganz T, Nemeth E. Iron Imports. IV. Hepcidin and Regulation of Body Iron Metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290(2):G199-203. PubMed PMID: 16407589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron imports. IV. Hepcidin and regulation of body iron metabolism. AU - Ganz,Tomas, AU - Nemeth,Elizabeta, PY - 2006/1/13/pubmed PY - 2006/3/3/medline PY - 2006/1/13/entrez SP - G199 EP - 203 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 290 IS - 2 N2 - Hepcidin, a small peptide synthesized in the liver, controls extracellular iron by regulating its intestinal absorption, placental transport, recycling by macrophages, and release from stores. Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin, the sole iron exporter in iron-transporting cells. In turn, hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia. Hepcidin is markedly induced during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations, and contributing to the anemia of inflammation. Hepcidin deficiency due to the dysregulation of its synthesis causes most known forms of hemochromatosis. SN - 0193-1857 UR - https://www.unboundmedicine.com/medline/citation/16407589/Iron_imports__IV__Hepcidin_and_regulation_of_body_iron_metabolism_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.00412.2005?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -