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Total homocysteine concentration and associated cardiovascular and renal implications in adults.
J Cardiovasc Nurs 2006 Jan-Feb; 21(1):40-6JC

Abstract

Hyperhomocysteinemia has been linked to an increased risk for cardiovascular (CV) disease since 1969. Recent epidemiological and cohort observations continue to confirm this relationship, provided the homocysteine concentration is elevated. This elevation in homocysteine concentration and increased CV disease risk are particularly strong in patients with renal disease. Hyperhomocysteinemia is also related to declining status of vitamins B6 and B12, folate, and in some cases riboflavin. This relationship between vitamins and homocysteine concentration has provided the basis for clinical trials targeting CV risk reduction by vitamin supplementation. This review describes the evidence behind vitamin supplementation as it pertains to homocysteine status and make recommendations for vitamin intake management in patients with hyperhomocysteinemia, including those patients with renal disease.

Authors+Show Affiliations

Penn Nursing, University of Pennsylvania, 420 Guardian Drive, Philadelphia, PA 19104-6096, USA. cbergen@nursing.upenn.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16407736

Citation

Bergen, Carol, and Charlene Compher. "Total Homocysteine Concentration and Associated Cardiovascular and Renal Implications in Adults." The Journal of Cardiovascular Nursing, vol. 21, no. 1, 2006, pp. 40-6.
Bergen C, Compher C. Total homocysteine concentration and associated cardiovascular and renal implications in adults. J Cardiovasc Nurs. 2006;21(1):40-6.
Bergen, C., & Compher, C. (2006). Total homocysteine concentration and associated cardiovascular and renal implications in adults. The Journal of Cardiovascular Nursing, 21(1), pp. 40-6.
Bergen C, Compher C. Total Homocysteine Concentration and Associated Cardiovascular and Renal Implications in Adults. J Cardiovasc Nurs. 2006;21(1):40-6. PubMed PMID: 16407736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total homocysteine concentration and associated cardiovascular and renal implications in adults. AU - Bergen,Carol, AU - Compher,Charlene, PY - 2006/1/13/pubmed PY - 2006/3/31/medline PY - 2006/1/13/entrez SP - 40 EP - 6 JF - The Journal of cardiovascular nursing JO - J Cardiovasc Nurs VL - 21 IS - 1 N2 - Hyperhomocysteinemia has been linked to an increased risk for cardiovascular (CV) disease since 1969. Recent epidemiological and cohort observations continue to confirm this relationship, provided the homocysteine concentration is elevated. This elevation in homocysteine concentration and increased CV disease risk are particularly strong in patients with renal disease. Hyperhomocysteinemia is also related to declining status of vitamins B6 and B12, folate, and in some cases riboflavin. This relationship between vitamins and homocysteine concentration has provided the basis for clinical trials targeting CV risk reduction by vitamin supplementation. This review describes the evidence behind vitamin supplementation as it pertains to homocysteine status and make recommendations for vitamin intake management in patients with hyperhomocysteinemia, including those patients with renal disease. SN - 0889-4655 UR - https://www.unboundmedicine.com/medline/citation/16407736/Total_homocysteine_concentration_and_associated_cardiovascular_and_renal_implications_in_adults_ L2 - http://Insights.ovid.com/pubmed?pmid=16407736 DB - PRIME DP - Unbound Medicine ER -