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[Conformationally altered proteins cause neurodegenerative diseases].
Lakartidningen. 2005 Nov 21-27; 102(47):3542-3, 3545-6, 3549 passim.L

Abstract

Brain aggregates of conformationally altered proteins are key features of neurodegeneration and are believed to directly cause or contribute to disease development. Mechanisms underlying the dysregulation of proteins in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and other neurodegenerative disorders are now being characterized, due to the discovery of genes causing rare disease forms. As of today, only symptomatic pharmacotherapies are available, but new insights into the underlying molecular mechanisms are providing strategies to prevent or even cure these devastating disorders.

Authors+Show Affiliations

Ingelsson M
Geriatriska kliniken, AstraZeneca, Uppsala, Sweden. martin.ingelsson@pubcare.uu.se
Nilsson L
No affiliation info available
Basun H
No affiliation info available
Aquilonius SM
No affiliation info available
Lannfelt L
No affiliation info available

MeSH

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyotrophic Lateral SclerosisBrainCreutzfeldt-Jakob SyndromeDementiaHumansHuntington DiseaseLewy Body DiseaseMutationNerve Tissue ProteinsNeurodegenerative DiseasesParkinson DiseasePrionsSuperoxide Dismutasealpha-Synucleintau Proteins

Pub Type(s)

English Abstract
Journal Article
Review

Language

swe

PubMed ID

16408392

Citation

Ingelsson, Martin, et al. "[Conformationally Altered Proteins Cause Neurodegenerative Diseases]." Lakartidningen, vol. 102, no. 47, 2005, 3542-3, 3545-6, 3549 passim.
Ingelsson M, Nilsson L, Basun H, et al. [Conformationally altered proteins cause neurodegenerative diseases]. Lakartidningen. 2005;102(47):3542-3, 3545-6, 3549 passim.
Ingelsson, M., Nilsson, L., Basun, H., Aquilonius, S. M., & Lannfelt, L. (2005). [Conformationally altered proteins cause neurodegenerative diseases]. Lakartidningen, 102(47), 3542-3, 3545-6, 3549 passim.
Ingelsson M, et al. [Conformationally Altered Proteins Cause Neurodegenerative Diseases]. Lakartidningen. 2005 Nov 21-27;102(47):3542-3, 3545-6, 3549 passim. PubMed PMID: 16408392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Conformationally altered proteins cause neurodegenerative diseases]. AU - Ingelsson,Martin, AU - Nilsson,Lars, AU - Basun,Hans, AU - Aquilonius,Sten-Magnus, AU - Lannfelt,Lars, PY - 2006/1/18/pubmed PY - 2006/1/19/medline PY - 2006/1/18/entrez SP - 3542-3, 3545-6, 3549 passim JF - Lakartidningen JO - Lakartidningen VL - 102 IS - 47 N2 - Brain aggregates of conformationally altered proteins are key features of neurodegeneration and are believed to directly cause or contribute to disease development. Mechanisms underlying the dysregulation of proteins in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and other neurodegenerative disorders are now being characterized, due to the discovery of genes causing rare disease forms. As of today, only symptomatic pharmacotherapies are available, but new insights into the underlying molecular mechanisms are providing strategies to prevent or even cure these devastating disorders. SN - 0023-7205 UR - https://www.unboundmedicine.com/medline/citation/16408392/[Conformationally_altered_proteins_cause_neurodegenerative_diseases]_ DB - PRIME DP - Unbound Medicine ER -