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Plant, synthetic, and endogenous cannabinoids in medicine.
Annu Rev Med 2006; 57:553-74AR

Abstract

Although used for more than 4000 years for recreational and medicinal purposes, Cannabis and its best-known pharmacologically active constituents, the cannabinoids, became a protagonist in medical research only recently. This revival of interest is explained by the finding in the 1990s of the mechanism of action of the main psychotropic cannabinoid, Delta9-tetrahydrocannabinol (THC), which acts through specific membrane receptors, the cannabinoid receptors. The molecular characterization of these receptors allowed the development of synthetic molecules with cannabinoid and noncannabinoid structure and with higher selectivity, metabolic stability, and efficacy than THC, as well as the development of antagonists that have already found pharmaceutical application. The finding of endogenous agonists at these receptors, the endocannabinoids, opened new therapeutic possibilities through the modulation of the activity of cannabinoid receptors by targeting the biochemical mechanisms controlling endocannabinoid tissue levels.

Authors+Show Affiliations

Endocannabinoid Research Group, Institutes of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy. vdimarzo@icmib.na.cnr.itNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16409166

Citation

Di Marzo, Vincenzo, and Luciano De Petrocellis. "Plant, Synthetic, and Endogenous Cannabinoids in Medicine." Annual Review of Medicine, vol. 57, 2006, pp. 553-74.
Di Marzo V, Petrocellis LD. Plant, synthetic, and endogenous cannabinoids in medicine. Annu Rev Med. 2006;57:553-74.
Di Marzo, V., & Petrocellis, L. D. (2006). Plant, synthetic, and endogenous cannabinoids in medicine. Annual Review of Medicine, 57, pp. 553-74.
Di Marzo V, Petrocellis LD. Plant, Synthetic, and Endogenous Cannabinoids in Medicine. Annu Rev Med. 2006;57:553-74. PubMed PMID: 16409166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant, synthetic, and endogenous cannabinoids in medicine. AU - Di Marzo,Vincenzo, AU - Petrocellis,Luciano De, PY - 2006/1/18/pubmed PY - 2006/5/5/medline PY - 2006/1/18/entrez SP - 553 EP - 74 JF - Annual review of medicine JO - Annu. Rev. Med. VL - 57 N2 - Although used for more than 4000 years for recreational and medicinal purposes, Cannabis and its best-known pharmacologically active constituents, the cannabinoids, became a protagonist in medical research only recently. This revival of interest is explained by the finding in the 1990s of the mechanism of action of the main psychotropic cannabinoid, Delta9-tetrahydrocannabinol (THC), which acts through specific membrane receptors, the cannabinoid receptors. The molecular characterization of these receptors allowed the development of synthetic molecules with cannabinoid and noncannabinoid structure and with higher selectivity, metabolic stability, and efficacy than THC, as well as the development of antagonists that have already found pharmaceutical application. The finding of endogenous agonists at these receptors, the endocannabinoids, opened new therapeutic possibilities through the modulation of the activity of cannabinoid receptors by targeting the biochemical mechanisms controlling endocannabinoid tissue levels. SN - 0066-4219 UR - https://www.unboundmedicine.com/medline/citation/16409166/Plant_synthetic_and_endogenous_cannabinoids_in_medicine_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev.med.57.011205.135648?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -