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Angiostrongylus cantonensis: efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis.
Exp Parasitol. 2006 May; 113(1):8-15.EP

Abstract

Angiostrongyliasis is one of the common causes leading to eosinophilic meningitis. Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) may play a role in the pathogenesis. Administration of steroid drugs has been reported to possibly relieve the symptoms of eosinophilic meningitis. This study evaluates the curative effects of albendazole-dexamethasone co-therapy on eosinophilic meningitis in BALB/c mice. Assay indicators for the therapeutic effect include worm recovery, histopathological score of meningitis, tPA, uPA, total protein, and leukocyte counts. The results show that the albendazole-dexamethasone co-therapy significantly decreased (P<0.05) these factors after treatment on day 5 post-inoculation (PI), in contrast to treatment on 15 PI. Thus, the timing of medication is important and is closely related to the anthelmintic efficacy of a drug. At the same dosage and days post-infection, the earlier administration shows better results. This study showed that albendazole-dexamethasone co-therapy is an effective approach for the treatment of parasitic meningitis.

Authors+Show Affiliations

Department of Entomology, National Chung-Hsing University, Taichung 402, Taiwan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16410005

Citation

Tu, Wu-Chun, and Shih-Chan Lai. "Angiostrongylus Cantonensis: Efficacy of Albendazole-dexamethasone Co-therapy Against Infection-induced Plasminogen Activators and Eosinophilic Meningitis." Experimental Parasitology, vol. 113, no. 1, 2006, pp. 8-15.
Tu WC, Lai SC. Angiostrongylus cantonensis: efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis. Exp Parasitol. 2006;113(1):8-15.
Tu, W. C., & Lai, S. C. (2006). Angiostrongylus cantonensis: efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis. Experimental Parasitology, 113(1), 8-15.
Tu WC, Lai SC. Angiostrongylus Cantonensis: Efficacy of Albendazole-dexamethasone Co-therapy Against Infection-induced Plasminogen Activators and Eosinophilic Meningitis. Exp Parasitol. 2006;113(1):8-15. PubMed PMID: 16410005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiostrongylus cantonensis: efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis. AU - Tu,Wu-Chun, AU - Lai,Shih-Chan, Y1 - 2006/01/10/ PY - 2005/06/22/received PY - 2005/11/22/revised PY - 2005/11/24/accepted PY - 2006/1/18/pubmed PY - 2006/5/19/medline PY - 2006/1/18/entrez SP - 8 EP - 15 JF - Experimental parasitology JO - Exp Parasitol VL - 113 IS - 1 N2 - Angiostrongyliasis is one of the common causes leading to eosinophilic meningitis. Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) may play a role in the pathogenesis. Administration of steroid drugs has been reported to possibly relieve the symptoms of eosinophilic meningitis. This study evaluates the curative effects of albendazole-dexamethasone co-therapy on eosinophilic meningitis in BALB/c mice. Assay indicators for the therapeutic effect include worm recovery, histopathological score of meningitis, tPA, uPA, total protein, and leukocyte counts. The results show that the albendazole-dexamethasone co-therapy significantly decreased (P<0.05) these factors after treatment on day 5 post-inoculation (PI), in contrast to treatment on 15 PI. Thus, the timing of medication is important and is closely related to the anthelmintic efficacy of a drug. At the same dosage and days post-infection, the earlier administration shows better results. This study showed that albendazole-dexamethasone co-therapy is an effective approach for the treatment of parasitic meningitis. SN - 0014-4894 UR - https://www.unboundmedicine.com/medline/citation/16410005/Angiostrongylus_cantonensis:_efficacy_of_albendazole_dexamethasone_co_therapy_against_infection_induced_plasminogen_activators_and_eosinophilic_meningitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(05)00312-7 DB - PRIME DP - Unbound Medicine ER -