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Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids.

Abstract

The aetiology of primary open-angle glaucoma (POAG), which is the commonest cause of non-remediable blindness and visual impairment, is not well understood. Nevertheless, increased intraocular pressure, and vascular factors such as ocular blood flow deficits are thought to be risk factors. There is evidence of decreased optic nerve blood velocity and increased red blood cell aggregability in POAG. These factors are influenced by fatty acids. We have investigated if glaucoma patients have abnormal blood fatty acid composition. Patients with POAG (n=10) and their healthy siblings (n=8) were enrolled. Compared with their healthy siblings, the glaucoma patients had reduced eicosapentaenoic (EPA, P<0.01), and docosahexaenoic (DHA, P<0.05) fatty acids and total omega3 long-chain polyunsaturated fatty acids (LCPUFA) (P<0.05) in red cell choline phosphoglycerides (CPG); decreased EPA (P<0.05) in ethanolamine phosphoglycerides (EPG); lower EPA (P<0.05) and total omega3 LCPUFA (P<0.05) in serine phosphoglycerides (SPG). Similarly, they had reduced EPA, DHA and total omega3 LCPUFA in plasma CPG (P<0.005) and triglycerides (P<0.05). These findings may be significant, since EPA and DHA could modulate impaired systemic microcirculation and ocular blood flow and optic neuropathy, which are the main physiological changes associated with glaucoma.

Authors+Show Affiliations

Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, North Campus, 166-220 Holloway Road, London N7 8DB, UK, and Department of Ophthalmology, University of Nigeria Teaching Hospital, Enugu, Nigeria. Hor016@londonmet.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16410047

Citation

Ren, Hongmei, et al. "Primary Open-angle Glaucoma Patients Have Reduced Levels of Blood Docosahexaenoic and Eicosapentaenoic Acids." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 74, no. 3, 2006, pp. 157-63.
Ren H, Magulike N, Ghebremeskel K, et al. Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. Prostaglandins Leukot Essent Fatty Acids. 2006;74(3):157-63.
Ren, H., Magulike, N., Ghebremeskel, K., & Crawford, M. (2006). Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 74(3), pp. 157-63.
Ren H, et al. Primary Open-angle Glaucoma Patients Have Reduced Levels of Blood Docosahexaenoic and Eicosapentaenoic Acids. Prostaglandins Leukot Essent Fatty Acids. 2006;74(3):157-63. PubMed PMID: 16410047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. AU - Ren,Hongmei, AU - Magulike,Nwabueze, AU - Ghebremeskel,Kebreab, AU - Crawford,Michael, Y1 - 2006/01/10/ PY - 2005/08/11/received PY - 2005/11/04/revised PY - 2005/11/24/accepted PY - 2006/1/18/pubmed PY - 2006/5/31/medline PY - 2006/1/18/entrez SP - 157 EP - 63 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 74 IS - 3 N2 - The aetiology of primary open-angle glaucoma (POAG), which is the commonest cause of non-remediable blindness and visual impairment, is not well understood. Nevertheless, increased intraocular pressure, and vascular factors such as ocular blood flow deficits are thought to be risk factors. There is evidence of decreased optic nerve blood velocity and increased red blood cell aggregability in POAG. These factors are influenced by fatty acids. We have investigated if glaucoma patients have abnormal blood fatty acid composition. Patients with POAG (n=10) and their healthy siblings (n=8) were enrolled. Compared with their healthy siblings, the glaucoma patients had reduced eicosapentaenoic (EPA, P<0.01), and docosahexaenoic (DHA, P<0.05) fatty acids and total omega3 long-chain polyunsaturated fatty acids (LCPUFA) (P<0.05) in red cell choline phosphoglycerides (CPG); decreased EPA (P<0.05) in ethanolamine phosphoglycerides (EPG); lower EPA (P<0.05) and total omega3 LCPUFA (P<0.05) in serine phosphoglycerides (SPG). Similarly, they had reduced EPA, DHA and total omega3 LCPUFA in plasma CPG (P<0.005) and triglycerides (P<0.05). These findings may be significant, since EPA and DHA could modulate impaired systemic microcirculation and ocular blood flow and optic neuropathy, which are the main physiological changes associated with glaucoma. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16410047/Primary_open_angle_glaucoma_patients_have_reduced_levels_of_blood_docosahexaenoic_and_eicosapentaenoic_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(05)00196-1 DB - PRIME DP - Unbound Medicine ER -