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The effect of social engagement on incident dementia: the Honolulu-Asia Aging Study.
Am J Epidemiol 2006; 163(5):433-40AJ

Abstract

The authors examined whether low levels of social engagement in midlife and late life were associated with the risk of incident dementia in 2,513 Japanese-American men who have been followed since 1965 as part of the Honolulu Heart Program and the Honolulu-Asia Aging Study. In 1991, assessment of dementia began; incident dementia cases (n = 222) were diagnosed in 1994 and 1997. Social engagement was assessed in midlife (1968) and late life (1991). The relation between social engagement and dementia risk was examined using Cox proportional hazards models. No level of midlife social engagement was associated with the risk of dementia. In late life, compared with participants in the highest quartile of late-life social engagement, those in the lowest quartile had a significantly increased risk of dementia (hazard ratio = 2.34, 95% confidence interval: 1.18, 4.65). However, compared with those who were in the highest quartile of social engagement at both midlife and late life, only decreased social engagement from midlife to late life was associated with an increased risk of dementia (hazard ratio = 1.87, 95% confidence interval: 1.12, 3.13). Although low social engagement in late life is associated with risk of dementia, levels of late-life social engagement may already have been modified by the dementing process and may be associated with prodromal dementia.

Authors+Show Affiliations

Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892-9205, USA. saczynsj@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16410348

Citation

Saczynski, Jane S., et al. "The Effect of Social Engagement On Incident Dementia: the Honolulu-Asia Aging Study." American Journal of Epidemiology, vol. 163, no. 5, 2006, pp. 433-40.
Saczynski JS, Pfeifer LA, Masaki K, et al. The effect of social engagement on incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol. 2006;163(5):433-40.
Saczynski, J. S., Pfeifer, L. A., Masaki, K., Korf, E. S., Laurin, D., White, L., & Launer, L. J. (2006). The effect of social engagement on incident dementia: the Honolulu-Asia Aging Study. American Journal of Epidemiology, 163(5), pp. 433-40.
Saczynski JS, et al. The Effect of Social Engagement On Incident Dementia: the Honolulu-Asia Aging Study. Am J Epidemiol. 2006 Mar 1;163(5):433-40. PubMed PMID: 16410348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of social engagement on incident dementia: the Honolulu-Asia Aging Study. AU - Saczynski,Jane S, AU - Pfeifer,Lisa A, AU - Masaki,Kamal, AU - Korf,Esther S C, AU - Laurin,Danielle, AU - White,Lon, AU - Launer,Lenore J, Y1 - 2006/01/12/ PY - 2006/1/18/pubmed PY - 2006/3/24/medline PY - 2006/1/18/entrez SP - 433 EP - 40 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 163 IS - 5 N2 - The authors examined whether low levels of social engagement in midlife and late life were associated with the risk of incident dementia in 2,513 Japanese-American men who have been followed since 1965 as part of the Honolulu Heart Program and the Honolulu-Asia Aging Study. In 1991, assessment of dementia began; incident dementia cases (n = 222) were diagnosed in 1994 and 1997. Social engagement was assessed in midlife (1968) and late life (1991). The relation between social engagement and dementia risk was examined using Cox proportional hazards models. No level of midlife social engagement was associated with the risk of dementia. In late life, compared with participants in the highest quartile of late-life social engagement, those in the lowest quartile had a significantly increased risk of dementia (hazard ratio = 2.34, 95% confidence interval: 1.18, 4.65). However, compared with those who were in the highest quartile of social engagement at both midlife and late life, only decreased social engagement from midlife to late life was associated with an increased risk of dementia (hazard ratio = 1.87, 95% confidence interval: 1.12, 3.13). Although low social engagement in late life is associated with risk of dementia, levels of late-life social engagement may already have been modified by the dementing process and may be associated with prodromal dementia. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16410348/The_effect_of_social_engagement_on_incident_dementia:_the_Honolulu_Asia_Aging_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj061 DB - PRIME DP - Unbound Medicine ER -