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Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma.
Graefes Arch Clin Exp Ophthalmol. 2006 Aug; 244(8):978-83.GA

Abstract

PURPOSE

To investigate interocular differences in retrobulbar flow velocities in patients with asymmetric glaucomatous visual field loss.

METHODS

Twenty-five patients with primary open-angle glaucoma (POAG) and asymmetric visual field loss were included in this study. Asymmetric visual field loss was defined as a difference of the global index mean deviation (MD) >6 dB between the two eyes. Flow velocities (peak systolic velocity PSV and end-diastolic velocity EDV) and resistive indices (RI) of the ophthalmic artery (OA), central retinal artery (CRA), and nasal and temporal posterior ciliary arteries were measured by means of colour Doppler imaging.

RESULTS

MD of eyes with more severe glaucomatous visual field loss was -18.3+/-7.8 dB vs -6.8+/-5.5 dB (p<0.0001) in the less affected eyes. The PSV and the EDV of the CRA and the PSV of the OA were significantly decreased in eyes with more severe glaucomatous visual field loss (CRA PSV: 7.6+/-2.0 cm/s vs 8.3+/-1.7 cm/s, p=0.04; CRA EDV: 2.24+/-0.5 cm/s vs 2.55+/-0.6 cm/s, p<0.007; OA PSV: 29.7+/-9.9 cm/s vs 32.7+/-11.5 cm/s, p<0.02). None of the other differences in velocity or resistive index were significant.

CONCLUSIONS

Patients with asymmetric glaucomatous visual field loss exhibit asymmetric flow velocities of the CRA and OA. Patients with more severe damage display reduced flow velocities in retrobulbar vessels in POAG.

Authors+Show Affiliations

Department of Ophthalmology, RWTH Aachen University, Pauwelsstrasse 30, 52057, Aachen, Germany. nplange@ukaachen.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16411100

Citation

Plange, Niklas, et al. "Asymmetric Visual Field Loss and Retrobulbar Haemodynamics in Primary Open-angle Glaucoma." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 244, no. 8, 2006, pp. 978-83.
Plange N, Kaup M, Arend O, et al. Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 2006;244(8):978-83.
Plange, N., Kaup, M., Arend, O., & Remky, A. (2006). Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 244(8), 978-83.
Plange N, et al. Asymmetric Visual Field Loss and Retrobulbar Haemodynamics in Primary Open-angle Glaucoma. Graefes Arch Clin Exp Ophthalmol. 2006;244(8):978-83. PubMed PMID: 16411100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma. AU - Plange,Niklas, AU - Kaup,Marion, AU - Arend,Oliver, AU - Remky,Andreas, Y1 - 2006/01/13/ PY - 2005/08/08/received PY - 2005/11/22/accepted PY - 2005/11/18/revised PY - 2006/1/18/pubmed PY - 2007/3/27/medline PY - 2006/1/18/entrez SP - 978 EP - 83 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 244 IS - 8 N2 - PURPOSE: To investigate interocular differences in retrobulbar flow velocities in patients with asymmetric glaucomatous visual field loss. METHODS: Twenty-five patients with primary open-angle glaucoma (POAG) and asymmetric visual field loss were included in this study. Asymmetric visual field loss was defined as a difference of the global index mean deviation (MD) >6 dB between the two eyes. Flow velocities (peak systolic velocity PSV and end-diastolic velocity EDV) and resistive indices (RI) of the ophthalmic artery (OA), central retinal artery (CRA), and nasal and temporal posterior ciliary arteries were measured by means of colour Doppler imaging. RESULTS: MD of eyes with more severe glaucomatous visual field loss was -18.3+/-7.8 dB vs -6.8+/-5.5 dB (p<0.0001) in the less affected eyes. The PSV and the EDV of the CRA and the PSV of the OA were significantly decreased in eyes with more severe glaucomatous visual field loss (CRA PSV: 7.6+/-2.0 cm/s vs 8.3+/-1.7 cm/s, p=0.04; CRA EDV: 2.24+/-0.5 cm/s vs 2.55+/-0.6 cm/s, p<0.007; OA PSV: 29.7+/-9.9 cm/s vs 32.7+/-11.5 cm/s, p<0.02). None of the other differences in velocity or resistive index were significant. CONCLUSIONS: Patients with asymmetric glaucomatous visual field loss exhibit asymmetric flow velocities of the CRA and OA. Patients with more severe damage display reduced flow velocities in retrobulbar vessels in POAG. SN - 0721-832X UR - https://www.unboundmedicine.com/medline/citation/16411100/Asymmetric_visual_field_loss_and_retrobulbar_haemodynamics_in_primary_open_angle_glaucoma_ L2 - https://dx.doi.org/10.1007/s00417-005-0227-9 DB - PRIME DP - Unbound Medicine ER -