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Effects of Concord grape juice on cognitive and motor deficits in aging.
Nutrition. 2006 Mar; 22(3):295-302.N

Abstract

OBJECTIVE

Animals and humans show increased motor and cognitive declines with aging that are thought to be due to increased susceptibility to the long-term effects of oxidative stress and inflammation. Previous findings have suggested that reversals in these age-related declines might be accomplished by increasing the dietary intake of polyphenolics found in fruits and vegetables, especially those identified as being high in antioxidant and anti-inflammatory activities.

METHODS

We investigated the beneficial effects of two concentrations of Concord grape juice (10% and 50%) compared with a calorically matched placebo for their effectiveness in reversing age-related deficits in behavioral and neuronal functions in aged Fischer 344 rats.

RESULTS

Rats that drank the 10% grape juice from age 19 to 21 mo had improvements in oxotremorine enhancement of K+-evoked release of dopamine from striatal slices and in cognitive performance on the Morris water maze, and the 50% grape juice produced improvements in motor function.

CONCLUSIONS

These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, polyphenolics in foods may be beneficial in reversing the course of neuronal and behavioral aging, possibly through a multiplicity of direct and indirect effects that can affect a variety of neuronal parameters.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA. barbara.hale@tufts.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16412610

Citation

Shukitt-Hale, Barbara, et al. "Effects of Concord Grape Juice On Cognitive and Motor Deficits in Aging." Nutrition (Burbank, Los Angeles County, Calif.), vol. 22, no. 3, 2006, pp. 295-302.
Shukitt-Hale B, Carey A, Simon L, et al. Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition. 2006;22(3):295-302.
Shukitt-Hale, B., Carey, A., Simon, L., Mark, D. A., & Joseph, J. A. (2006). Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition (Burbank, Los Angeles County, Calif.), 22(3), 295-302.
Shukitt-Hale B, et al. Effects of Concord Grape Juice On Cognitive and Motor Deficits in Aging. Nutrition. 2006;22(3):295-302. PubMed PMID: 16412610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Concord grape juice on cognitive and motor deficits in aging. AU - Shukitt-Hale,Barbara, AU - Carey,Amanda, AU - Simon,Laura, AU - Mark,David A, AU - Joseph,James A, Y1 - 2006/01/18/ PY - 2005/01/20/received PY - 2005/07/23/accepted PY - 2006/1/18/pubmed PY - 2006/8/1/medline PY - 2006/1/18/entrez SP - 295 EP - 302 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 22 IS - 3 N2 - OBJECTIVE: Animals and humans show increased motor and cognitive declines with aging that are thought to be due to increased susceptibility to the long-term effects of oxidative stress and inflammation. Previous findings have suggested that reversals in these age-related declines might be accomplished by increasing the dietary intake of polyphenolics found in fruits and vegetables, especially those identified as being high in antioxidant and anti-inflammatory activities. METHODS: We investigated the beneficial effects of two concentrations of Concord grape juice (10% and 50%) compared with a calorically matched placebo for their effectiveness in reversing age-related deficits in behavioral and neuronal functions in aged Fischer 344 rats. RESULTS: Rats that drank the 10% grape juice from age 19 to 21 mo had improvements in oxotremorine enhancement of K+-evoked release of dopamine from striatal slices and in cognitive performance on the Morris water maze, and the 50% grape juice produced improvements in motor function. CONCLUSIONS: These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, polyphenolics in foods may be beneficial in reversing the course of neuronal and behavioral aging, possibly through a multiplicity of direct and indirect effects that can affect a variety of neuronal parameters. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16412610/Effects_of_Concord_grape_juice_on_cognitive_and_motor_deficits_in_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00298-4 DB - PRIME DP - Unbound Medicine ER -