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The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure.
J Am Coll Cardiol. 2006 Jan 17; 47(2):354-61.JACC

Abstract

OBJECTIVES

The purpose of this study was to determine the prevalence of thiamin deficiency (TD) in a cross section of hospitalized congestive heart failure (CHF) patients and to investigate factors that contribute to its development.

BACKGROUND

Thiamin deficiency manifests as symptoms of CHF and, therefore, may worsen existing heart failure. Congestive heart failure patients may be at increased risk for TD as a result of diuretic-induced urine thiamin excretion, disease severity, malnutrition, and advanced age.

METHODS

Erythrocyte thiamin pyrophosphate concentrations, using high-performance liquid chromatography, were measured in 100 CHF patients and compared to 50 control subjects. Variables including diuretics (type and dose), left ventricle dysfunction, New York Heart Association functional classification, creatinine clearance, thiamin intake (diet and supplements), malnutrition, appetite ratings, and age were related to TD using univariate statistics and multiple logistic regression analysis.

RESULTS

Thiamin deficiency was more prevalent in CHF patients (33%) compared to control subjects (12%) (p = 0.007). Thiamin deficiency was related to urine thiamin loss (p = 0.03), non-use of thiamin-containing supplements (p = 0.06), and preserved renal function (p = 0.05). Increased urinary thiamin loss (mug/g creatinine) was found to be the only significant positive predictor of thiamin status on multiple logistic regression analysis (p = 0.03).

CONCLUSIONS

One-third of hospitalized CHF patients were TD. In contrast to previous studies, increased urinary losses of thiamin were predictive of improved thiamin status. Thiamin supplementation may be protective against TD in the clinical setting. Future studies are warranted to determine if thiamin supplementation improves thiamin status and disease severity in CHF patients.

Authors+Show Affiliations

Heart and Vascular Program, St. Michael's Hospital, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16412860

Citation

Hanninen, Stacy A., et al. "The Prevalence of Thiamin Deficiency in Hospitalized Patients With Congestive Heart Failure." Journal of the American College of Cardiology, vol. 47, no. 2, 2006, pp. 354-61.
Hanninen SA, Darling PB, Sole MJ, et al. The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. J Am Coll Cardiol. 2006;47(2):354-61.
Hanninen, S. A., Darling, P. B., Sole, M. J., Barr, A., & Keith, M. E. (2006). The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. Journal of the American College of Cardiology, 47(2), 354-61.
Hanninen SA, et al. The Prevalence of Thiamin Deficiency in Hospitalized Patients With Congestive Heart Failure. J Am Coll Cardiol. 2006 Jan 17;47(2):354-61. PubMed PMID: 16412860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. AU - Hanninen,Stacy A, AU - Darling,Pauline B, AU - Sole,Michael J, AU - Barr,Aiala, AU - Keith,Mary E, PY - 2004/12/15/received PY - 2005/08/09/revised PY - 2005/08/23/accepted PY - 2006/1/18/pubmed PY - 2006/3/17/medline PY - 2006/1/18/entrez SP - 354 EP - 61 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 47 IS - 2 N2 - OBJECTIVES: The purpose of this study was to determine the prevalence of thiamin deficiency (TD) in a cross section of hospitalized congestive heart failure (CHF) patients and to investigate factors that contribute to its development. BACKGROUND: Thiamin deficiency manifests as symptoms of CHF and, therefore, may worsen existing heart failure. Congestive heart failure patients may be at increased risk for TD as a result of diuretic-induced urine thiamin excretion, disease severity, malnutrition, and advanced age. METHODS: Erythrocyte thiamin pyrophosphate concentrations, using high-performance liquid chromatography, were measured in 100 CHF patients and compared to 50 control subjects. Variables including diuretics (type and dose), left ventricle dysfunction, New York Heart Association functional classification, creatinine clearance, thiamin intake (diet and supplements), malnutrition, appetite ratings, and age were related to TD using univariate statistics and multiple logistic regression analysis. RESULTS: Thiamin deficiency was more prevalent in CHF patients (33%) compared to control subjects (12%) (p = 0.007). Thiamin deficiency was related to urine thiamin loss (p = 0.03), non-use of thiamin-containing supplements (p = 0.06), and preserved renal function (p = 0.05). Increased urinary thiamin loss (mug/g creatinine) was found to be the only significant positive predictor of thiamin status on multiple logistic regression analysis (p = 0.03). CONCLUSIONS: One-third of hospitalized CHF patients were TD. In contrast to previous studies, increased urinary losses of thiamin were predictive of improved thiamin status. Thiamin supplementation may be protective against TD in the clinical setting. Future studies are warranted to determine if thiamin supplementation improves thiamin status and disease severity in CHF patients. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/16412860/The_prevalence_of_thiamin_deficiency_in_hospitalized_patients_with_congestive_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(05)02494-0 DB - PRIME DP - Unbound Medicine ER -