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PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma.
Psychoneuroendocrinology. 2006 May; 31(4):501-9.P

Abstract

Hypothalamic pituitary adrenal (HPA) axis and subjective stress response to a cold-water immersion task, the cold pressor task (CPT), in individuals (N=89) with post-traumatic stress disorder (PTSD) were examined. All tests were conducted at 08:00h after an overnight hospital stay. Plasma adrenocorticotrophin hormone (ACTH), cortisol, and subjective stress were examined at baseline and five post-task time points in controls (n=31), subjects with PTSD as a result of an index trauma during childhood (i.e. before age 18; n=25), and subjects with PTSD as a result of an index trauma as an adult (n=33). Approximately, 50% of individuals in both trauma groups were alcohol dependent, and the impact of this comorbidity was also examined. Subjects with PTSD, regardless of age of index trauma, had a less robust ACTH response as compared to controls. Regardless of the presence or absence of comorbid alcohol dependence, subjects with childhood trauma had lower cortisol at baseline and at all post-task measurement points and did not demonstrate the decrease in cortisol over the course of the 2h monitoring period seen in subjects with adult index trauma and controls. The findings reveal differences in the neuroendocrine response to the CPT in individuals with PTSD compared to control subjects, and differences in PTSD subjects when examined by age of index trauma.

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Authors+Show Affiliations

Santa Ana EJ
Division of Clinical Neuroscience, Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, 67 President Street, P.O. Box 250861, Charleston, SC 29425, USA.
Saladin ME
No affiliation info available
Back SE
No affiliation info available
Waldrop AE
No affiliation info available
Spratt EG
No affiliation info available
McRae AL
No affiliation info available
LaRowe SD
No affiliation info available
Timmerman MA
No affiliation info available
Upadhyaya H
No affiliation info available
Brady KT
No affiliation info available

MeSH

Adaptation, PsychologicalAdolescentAdrenocorticotropic HormoneAdultAge FactorsAlcoholismAnalysis of VarianceChild AbuseCircadian RhythmCold TemperatureFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemReference ValuesStress Disorders, Post-TraumaticStress, PhysiologicalThermosensing

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16413134

Citation

Santa Ana, Elizabeth J., et al. "PTSD and the HPA Axis: Differences in Response to the Cold Pressor Task Among Individuals With Child Vs. Adult Trauma." Psychoneuroendocrinology, vol. 31, no. 4, 2006, pp. 501-9.
Santa Ana EJ, Saladin ME, Back SE, et al. PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma. Psychoneuroendocrinology. 2006;31(4):501-9.
Santa Ana, E. J., Saladin, M. E., Back, S. E., Waldrop, A. E., Spratt, E. G., McRae, A. L., LaRowe, S. D., Timmerman, M. A., Upadhyaya, H., & Brady, K. T. (2006). PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma. Psychoneuroendocrinology, 31(4), 501-9.
Santa Ana EJ, et al. PTSD and the HPA Axis: Differences in Response to the Cold Pressor Task Among Individuals With Child Vs. Adult Trauma. Psychoneuroendocrinology. 2006;31(4):501-9. PubMed PMID: 16413134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma. AU - Santa Ana,Elizabeth J, AU - Saladin,Michael E, AU - Back,Sudie E, AU - Waldrop,Angela E, AU - Spratt,Eve G, AU - McRae,Aimee L, AU - LaRowe,Steven D, AU - Timmerman,Mary Ann, AU - Upadhyaya,Himanshu, AU - Brady,Kathleen T, Y1 - 2006/01/18/ PY - 2005/05/24/received PY - 2005/10/25/revised PY - 2005/11/22/accepted PY - 2006/1/18/pubmed PY - 2006/6/2/medline PY - 2006/1/18/entrez SP - 501 EP - 9 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 4 N2 - Hypothalamic pituitary adrenal (HPA) axis and subjective stress response to a cold-water immersion task, the cold pressor task (CPT), in individuals (N=89) with post-traumatic stress disorder (PTSD) were examined. All tests were conducted at 08:00h after an overnight hospital stay. Plasma adrenocorticotrophin hormone (ACTH), cortisol, and subjective stress were examined at baseline and five post-task time points in controls (n=31), subjects with PTSD as a result of an index trauma during childhood (i.e. before age 18; n=25), and subjects with PTSD as a result of an index trauma as an adult (n=33). Approximately, 50% of individuals in both trauma groups were alcohol dependent, and the impact of this comorbidity was also examined. Subjects with PTSD, regardless of age of index trauma, had a less robust ACTH response as compared to controls. Regardless of the presence or absence of comorbid alcohol dependence, subjects with childhood trauma had lower cortisol at baseline and at all post-task measurement points and did not demonstrate the decrease in cortisol over the course of the 2h monitoring period seen in subjects with adult index trauma and controls. The findings reveal differences in the neuroendocrine response to the CPT in individuals with PTSD compared to control subjects, and differences in PTSD subjects when examined by age of index trauma. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/16413134/PTSD_and_the_HPA_axis:_differences_in_response_to_the_cold_pressor_task_among_individuals_with_child_vs__adult_trauma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(05)00245-3 DB - PRIME DP - Unbound Medicine ER -