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Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum.
Int J Pharm. 2006 Mar 09; 310(1-2):90-100.IJ

Abstract

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. Drug release from hot-melt extruded (HME) tablets containing either chitosan or xanthan gum was pH and buffer species dependent and the release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also exhibited pH and buffer species dependent release. In contrast, the HME tablets containing both chitosan and xanthan gum exhibited pH and buffer species independent sustained release. When placed in 0.1N HCl, the HME tablets formed a hydrogel that functioned to retard drug release in subsequent pH 6.8 and 7.4 phosphate buffers even when media contained high ionic strength, whereas tablets without chitosan did not form a hydrogel to retard drug release in 0.1N HCl. The HME tablets containing both chitosan and xanthan gum showed no significant change in drug release rate when stored at 40 degrees C for 1 month, 40 degrees C and 75% relative humidity (40 degrees C/75% RH) for 1 month, and 60 degrees C for 15 days.

Authors+Show Affiliations

Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 78712, USA. mamoru.fukuda@mb.kyorin-pharm.co.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16413153

Citation

Fukuda, Mamoru, et al. "Properties of Sustained Release Hot-melt Extruded Tablets Containing Chitosan and Xanthan Gum." International Journal of Pharmaceutics, vol. 310, no. 1-2, 2006, pp. 90-100.
Fukuda M, Peppas NA, McGinity JW. Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum. Int J Pharm. 2006;310(1-2):90-100.
Fukuda, M., Peppas, N. A., & McGinity, J. W. (2006). Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum. International Journal of Pharmaceutics, 310(1-2), 90-100.
Fukuda M, Peppas NA, McGinity JW. Properties of Sustained Release Hot-melt Extruded Tablets Containing Chitosan and Xanthan Gum. Int J Pharm. 2006 Mar 9;310(1-2):90-100. PubMed PMID: 16413153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum. AU - Fukuda,Mamoru, AU - Peppas,Nicholas A, AU - McGinity,James W, Y1 - 2006/01/18/ PY - 2005/07/07/received PY - 2005/11/18/revised PY - 2005/11/23/accepted PY - 2006/1/18/pubmed PY - 2006/6/3/medline PY - 2006/1/18/entrez SP - 90 EP - 100 JF - International journal of pharmaceutics JO - Int J Pharm VL - 310 IS - 1-2 N2 - The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. Drug release from hot-melt extruded (HME) tablets containing either chitosan or xanthan gum was pH and buffer species dependent and the release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also exhibited pH and buffer species dependent release. In contrast, the HME tablets containing both chitosan and xanthan gum exhibited pH and buffer species independent sustained release. When placed in 0.1N HCl, the HME tablets formed a hydrogel that functioned to retard drug release in subsequent pH 6.8 and 7.4 phosphate buffers even when media contained high ionic strength, whereas tablets without chitosan did not form a hydrogel to retard drug release in 0.1N HCl. The HME tablets containing both chitosan and xanthan gum showed no significant change in drug release rate when stored at 40 degrees C for 1 month, 40 degrees C and 75% relative humidity (40 degrees C/75% RH) for 1 month, and 60 degrees C for 15 days. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/16413153/Properties_of_sustained_release_hot_melt_extruded_tablets_containing_chitosan_and_xanthan_gum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(05)00837-9 DB - PRIME DP - Unbound Medicine ER -