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Analysis of serum and cerebrospinal fluid cytokine levels in subacute sclerosing panencephalitis in Papua New Guinea.
Cytokine. 2006 Jan 07; 33(1):17-20.C

Abstract

BACKGROUND

Subacute sclerosing panencephalitis (SSPE) is a rare progressive inflammatory disease characterized by the persistent infection of the brain by the measles virus. However, the immunological pathophysiology of SSPE is still unclear.

METHODS

We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in the serum and cerebrospinal fluid (CSF) of 23 patients with SSPE in Papua New Guinea (PNG), a country with a high incidence of SSPE, and Japanese controls by cytometric bead array or ELISA.

RESULTS

The serum IL-6 and IL-10 levels of SSPE patients were significantly higher than those of controls (p=0.0075, and p=0.0019, respectively). The serum IL-6 and IL-10 levels of SSPE patients with fever were significantly higher than those without fever (p=0.0107, and p=0.0006, respectively). The CSF IL-6 levels of SSPE patients were significantly higher than those of controls (p=0.0218). The CSF IL-6 levels of SSPE patients with myoclonic jerks were significantly higher than those without myoclonic jerks (p=0.0189). There were no differences in serum IFN-gamma, TNF-alpha, IL-2, IL-4, and sTNFR1, or CSF IFN-gamma, TNF-alpha, IL-2, IL-4, IL-10, and sTNFR1 levels between the affected patients and controls.

CONCLUSION

Our present study suggests that serum IL-6 and IL-10 levels are related to fever, and the CSF IL-6 level, myoclonic jerks, in SSPE patients in PNG.

Authors+Show Affiliations

Department of Pediatrics, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. ichiyama@yamaguchi-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16413199

Citation

Ichiyama, Takashi, et al. "Analysis of Serum and Cerebrospinal Fluid Cytokine Levels in Subacute Sclerosing Panencephalitis in Papua New Guinea." Cytokine, vol. 33, no. 1, 2006, pp. 17-20.
Ichiyama T, Siba P, Suarkia D, et al. Analysis of serum and cerebrospinal fluid cytokine levels in subacute sclerosing panencephalitis in Papua New Guinea. Cytokine. 2006;33(1):17-20.
Ichiyama, T., Siba, P., Suarkia, D., Reeder, J., Takasu, T., Miki, K., Maeba, S., & Furukawa, S. (2006). Analysis of serum and cerebrospinal fluid cytokine levels in subacute sclerosing panencephalitis in Papua New Guinea. Cytokine, 33(1), 17-20.
Ichiyama T, et al. Analysis of Serum and Cerebrospinal Fluid Cytokine Levels in Subacute Sclerosing Panencephalitis in Papua New Guinea. Cytokine. 2006 Jan 7;33(1):17-20. PubMed PMID: 16413199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of serum and cerebrospinal fluid cytokine levels in subacute sclerosing panencephalitis in Papua New Guinea. AU - Ichiyama,Takashi, AU - Siba,Peter, AU - Suarkia,Dagwin, AU - Reeder,John, AU - Takasu,Toshiaki, AU - Miki,Kenji, AU - Maeba,Shinji, AU - Furukawa,Susumu, Y1 - 2006/01/18/ PY - 2005/06/27/received PY - 2005/07/26/revised PY - 2005/11/03/accepted PY - 2006/1/18/pubmed PY - 2006/8/2/medline PY - 2006/1/18/entrez SP - 17 EP - 20 JF - Cytokine JO - Cytokine VL - 33 IS - 1 N2 - BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a rare progressive inflammatory disease characterized by the persistent infection of the brain by the measles virus. However, the immunological pathophysiology of SSPE is still unclear. METHODS: We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in the serum and cerebrospinal fluid (CSF) of 23 patients with SSPE in Papua New Guinea (PNG), a country with a high incidence of SSPE, and Japanese controls by cytometric bead array or ELISA. RESULTS: The serum IL-6 and IL-10 levels of SSPE patients were significantly higher than those of controls (p=0.0075, and p=0.0019, respectively). The serum IL-6 and IL-10 levels of SSPE patients with fever were significantly higher than those without fever (p=0.0107, and p=0.0006, respectively). The CSF IL-6 levels of SSPE patients were significantly higher than those of controls (p=0.0218). The CSF IL-6 levels of SSPE patients with myoclonic jerks were significantly higher than those without myoclonic jerks (p=0.0189). There were no differences in serum IFN-gamma, TNF-alpha, IL-2, IL-4, and sTNFR1, or CSF IFN-gamma, TNF-alpha, IL-2, IL-4, IL-10, and sTNFR1 levels between the affected patients and controls. CONCLUSION: Our present study suggests that serum IL-6 and IL-10 levels are related to fever, and the CSF IL-6 level, myoclonic jerks, in SSPE patients in PNG. SN - 1043-4666 UR - https://www.unboundmedicine.com/medline/citation/16413199/Analysis_of_serum_and_cerebrospinal_fluid_cytokine_levels_in_subacute_sclerosing_panencephalitis_in_Papua_New_Guinea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(05)00338-8 DB - PRIME DP - Unbound Medicine ER -