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Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease.
Brain Res Rev 2006; 51(2):176-211BR

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive decline that typically affects first memory and later executive functions, language, and visuospatial skills. This sequence of cognitive deterioration is thought to reflect the progressive invasion of the cerebral cortex by the two major pathological hallmarks of AD, neurofibrillary tangles (NFT) and senile plaques (SP), as well as degree of neuronal and synaptic loss. In atypical AD, prominent and early deficits are found in language, motor abilities, frontal and executive capacities, or visuospatial skills. These atypical clinical features are associated with an unusual pattern of NFT or SP formation that predominantly involves cortical areas usually spared in the course of the degenerative process. In an attempt to classify this highly heterogeneous subgroup, the present article provides an overview of clinicopathological analyses in patients with atypical progression of AD symptomatology with special reference to the relationship between specific cognitive and behavioral deficits and hierarchical patterns of AD lesion distribution within the cerebral cortex. On the basis of these representative examples of a cortical circuit-based approach to explore the mechanisms giving rise to AD neuropsychological expression, we also critically discuss the possibility to develop a matrix linking clinical presentations to degeneration of forward and backward long corticocortical pathways in this disorder.

Authors+Show Affiliations

Division of Old Age Psychiatry, Department of Psychiatry-CHUV, Prilly-Lausanne, Switzerland. Armin.Von-Gunten@chuv.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16413610

Citation

von Gunten, Armin, et al. "Neural Substrates of Cognitive and Behavioral Deficits in Atypical Alzheimer's Disease." Brain Research Reviews, vol. 51, no. 2, 2006, pp. 176-211.
von Gunten A, Bouras C, Kövari E, et al. Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease. Brain Res Rev. 2006;51(2):176-211.
von Gunten, A., Bouras, C., Kövari, E., Giannakopoulos, P., & Hof, P. R. (2006). Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease. Brain Research Reviews, 51(2), pp. 176-211.
von Gunten A, et al. Neural Substrates of Cognitive and Behavioral Deficits in Atypical Alzheimer's Disease. Brain Res Rev. 2006;51(2):176-211. PubMed PMID: 16413610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease. AU - von Gunten,Armin, AU - Bouras,Constantin, AU - Kövari,Enikö, AU - Giannakopoulos,Panteleimon, AU - Hof,Patrick R, Y1 - 2006/01/18/ PY - 2005/06/16/received PY - 2005/11/04/revised PY - 2005/11/11/accepted PY - 2006/1/18/pubmed PY - 2006/9/9/medline PY - 2006/1/18/entrez SP - 176 EP - 211 JF - Brain research reviews JO - Brain Res Rev VL - 51 IS - 2 N2 - Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive decline that typically affects first memory and later executive functions, language, and visuospatial skills. This sequence of cognitive deterioration is thought to reflect the progressive invasion of the cerebral cortex by the two major pathological hallmarks of AD, neurofibrillary tangles (NFT) and senile plaques (SP), as well as degree of neuronal and synaptic loss. In atypical AD, prominent and early deficits are found in language, motor abilities, frontal and executive capacities, or visuospatial skills. These atypical clinical features are associated with an unusual pattern of NFT or SP formation that predominantly involves cortical areas usually spared in the course of the degenerative process. In an attempt to classify this highly heterogeneous subgroup, the present article provides an overview of clinicopathological analyses in patients with atypical progression of AD symptomatology with special reference to the relationship between specific cognitive and behavioral deficits and hierarchical patterns of AD lesion distribution within the cerebral cortex. On the basis of these representative examples of a cortical circuit-based approach to explore the mechanisms giving rise to AD neuropsychological expression, we also critically discuss the possibility to develop a matrix linking clinical presentations to degeneration of forward and backward long corticocortical pathways in this disorder. SN - 0165-0173 UR - https://www.unboundmedicine.com/medline/citation/16413610/Neural_substrates_of_cognitive_and_behavioral_deficits_in_atypical_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0173(05)00169-4 DB - PRIME DP - Unbound Medicine ER -