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Antiulcer and antimicrobial activity of Anogeissus latifolia.
J Ethnopharmacol. 2006 Jun 15; 106(1):57-61.JE

Abstract

Ethnobotanically, the bark of Anogeissus latifolia (Roxb. ex DC.) Wall. ex Guill. and Perr.(Combretaceae) has been reported to be used in the treatment of various disorders including stomach and skin diseases. We studied the antiulcer potential and antimicrobial activity of the 50% aqueous alcoholic extract in order to validate ethnobotanical claims regarding the plant use in the above-mentioned disorders. Gastroprotective potential of the Anogeissus latifolia extract (ALE) (100 and 200mg/kg/body weight) was studied on aspirin, cold-resistant stress (CRS), pylorus ligated (PL) and ethanol-induced ulcers. Status of the antioxidant enzymes superoxide dismutase (SOD) and catalase along with lipid peroxidation (LPO) was also studied in CRS-induced ulcers. The results of the present study showed for the first time that the ALE possessed gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by physical and chemical agents with a maximum of 84.16% curation (200mg/kg body weight) in CRS-induced ulcers. ALE decreased LPO and SOD with concomitant increase in catalase activity in CRS-induced ulcers. Moderate antibacterial activity and antifungal activity was also observed. High performance thin layer chromatography (HPTLC) showed the presence of gallic acid and ellagic acid (0.95%, w/w, 0.25%, w/w, respectively) in the plant. These findings could justify, at least partially, the inclusion of this plant in the management of gastric disorders in traditional medicine.

Authors+Show Affiliations

Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16413714

Citation

Govindarajan, R, et al. "Antiulcer and Antimicrobial Activity of Anogeissus Latifolia." Journal of Ethnopharmacology, vol. 106, no. 1, 2006, pp. 57-61.
Govindarajan R, Vijayakumar M, Singh M, et al. Antiulcer and antimicrobial activity of Anogeissus latifolia. J Ethnopharmacol. 2006;106(1):57-61.
Govindarajan, R., Vijayakumar, M., Singh, M., Rao, C. h. V., Shirwaikar, A., Rawat, A. K., & Pushpangadan, P. (2006). Antiulcer and antimicrobial activity of Anogeissus latifolia. Journal of Ethnopharmacology, 106(1), 57-61.
Govindarajan R, et al. Antiulcer and Antimicrobial Activity of Anogeissus Latifolia. J Ethnopharmacol. 2006 Jun 15;106(1):57-61. PubMed PMID: 16413714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcer and antimicrobial activity of Anogeissus latifolia. AU - Govindarajan,R, AU - Vijayakumar,M, AU - Singh,M, AU - Rao,Ch V, AU - Shirwaikar,A, AU - Rawat,A K S, AU - Pushpangadan,P, Y1 - 2006/01/18/ PY - 2005/06/06/received PY - 2005/11/18/revised PY - 2005/12/01/accepted PY - 2006/1/18/pubmed PY - 2006/11/15/medline PY - 2006/1/18/entrez SP - 57 EP - 61 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 106 IS - 1 N2 - Ethnobotanically, the bark of Anogeissus latifolia (Roxb. ex DC.) Wall. ex Guill. and Perr.(Combretaceae) has been reported to be used in the treatment of various disorders including stomach and skin diseases. We studied the antiulcer potential and antimicrobial activity of the 50% aqueous alcoholic extract in order to validate ethnobotanical claims regarding the plant use in the above-mentioned disorders. Gastroprotective potential of the Anogeissus latifolia extract (ALE) (100 and 200mg/kg/body weight) was studied on aspirin, cold-resistant stress (CRS), pylorus ligated (PL) and ethanol-induced ulcers. Status of the antioxidant enzymes superoxide dismutase (SOD) and catalase along with lipid peroxidation (LPO) was also studied in CRS-induced ulcers. The results of the present study showed for the first time that the ALE possessed gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by physical and chemical agents with a maximum of 84.16% curation (200mg/kg body weight) in CRS-induced ulcers. ALE decreased LPO and SOD with concomitant increase in catalase activity in CRS-induced ulcers. Moderate antibacterial activity and antifungal activity was also observed. High performance thin layer chromatography (HPTLC) showed the presence of gallic acid and ellagic acid (0.95%, w/w, 0.25%, w/w, respectively) in the plant. These findings could justify, at least partially, the inclusion of this plant in the management of gastric disorders in traditional medicine. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16413714/Antiulcer_and_antimicrobial_activity_of_Anogeissus_latifolia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00801-9 DB - PRIME DP - Unbound Medicine ER -