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Determination of the antimalaria drug artemether in pharmaceutical preparations by differential pulse polarography.
J Pharm Biomed Anal. 2006 May 03; 41(2):638-43.JP

Abstract

A differential pulse polarographic method has been developed for the determination of artemether in its pharmaceutical formulations. The polarographic behaviour of artemether was examined in various buffer systems over the pH range 3.0-10.0. In phosphate buffer pH 5.5/methanol solution (7:3, v/v) the differential pulse polarograms displayed reproducible peaks at Ep-0.01 V versus Ag/AgCl. Under these conditions strict linearity between artemether concentration and peak height was observed in 3.4x10(-7)-3.0x10(-5)mol/L concentration range (R=0.9998). The detection limit was calculated to be 32 ng/mL. The polarographic method was applied to the determination of the content of artemether in tablets and capsules by using the standard addition method. The analysis of tablets containing 20mg artemether showed a mean value of 19.73 mg with a relative standard deviation (R.S.D.) of +/-1.01%. A content of 39.74 mg artemether was found in 40 mg capsules with a relative standard deviation of +/-0.53%. The polarographic method is characterised to be cheap, precise and not time-consuming and can therefore be used for routine analysis of artemether in its pharmaceutical preparations.

Authors+Show Affiliations

Institute of Pharmaceutical Sciences, University Graz, Schubertstrasse 1, A-8010 Graz, Austria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16413733

Citation

Debnath, C, et al. "Determination of the Antimalaria Drug Artemether in Pharmaceutical Preparations By Differential Pulse Polarography." Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 2, 2006, pp. 638-43.
Debnath C, Haslinger E, Likussar W, et al. Determination of the antimalaria drug artemether in pharmaceutical preparations by differential pulse polarography. J Pharm Biomed Anal. 2006;41(2):638-43.
Debnath, C., Haslinger, E., Likussar, W., & Michelitsch, A. (2006). Determination of the antimalaria drug artemether in pharmaceutical preparations by differential pulse polarography. Journal of Pharmaceutical and Biomedical Analysis, 41(2), 638-43.
Debnath C, et al. Determination of the Antimalaria Drug Artemether in Pharmaceutical Preparations By Differential Pulse Polarography. J Pharm Biomed Anal. 2006 May 3;41(2):638-43. PubMed PMID: 16413733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of the antimalaria drug artemether in pharmaceutical preparations by differential pulse polarography. AU - Debnath,C, AU - Haslinger,E, AU - Likussar,W, AU - Michelitsch,A, Y1 - 2006/01/18/ PY - 2005/07/06/received PY - 2005/11/30/revised PY - 2005/12/02/accepted PY - 2006/1/18/pubmed PY - 2007/8/2/medline PY - 2006/1/18/entrez SP - 638 EP - 43 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 41 IS - 2 N2 - A differential pulse polarographic method has been developed for the determination of artemether in its pharmaceutical formulations. The polarographic behaviour of artemether was examined in various buffer systems over the pH range 3.0-10.0. In phosphate buffer pH 5.5/methanol solution (7:3, v/v) the differential pulse polarograms displayed reproducible peaks at Ep-0.01 V versus Ag/AgCl. Under these conditions strict linearity between artemether concentration and peak height was observed in 3.4x10(-7)-3.0x10(-5)mol/L concentration range (R=0.9998). The detection limit was calculated to be 32 ng/mL. The polarographic method was applied to the determination of the content of artemether in tablets and capsules by using the standard addition method. The analysis of tablets containing 20mg artemether showed a mean value of 19.73 mg with a relative standard deviation (R.S.D.) of +/-1.01%. A content of 39.74 mg artemether was found in 40 mg capsules with a relative standard deviation of +/-0.53%. The polarographic method is characterised to be cheap, precise and not time-consuming and can therefore be used for routine analysis of artemether in its pharmaceutical preparations. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/16413733/Determination_of_the_antimalaria_drug_artemether_in_pharmaceutical_preparations_by_differential_pulse_polarography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(05)00755-7 DB - PRIME DP - Unbound Medicine ER -