Tags

Type your tag names separated by a space and hit enter

Decreased wall shear stress in the common carotid artery of patients with peripheral arterial disease or abdominal aortic aneurysm: relation to blood rheology, vascular risk factors, and intima-media thickness.
J Vasc Surg. 2006 Jan; 43(1):56-63; discussion 63.JV

Abstract

BACKGROUND

Wall shear stress, a local risk factor of atherosclerosis, is decreased in the common carotid artery of patients with vascular risk factors. We evaluated wall shear stress in the common carotid artery of patients with symptomatic peripheral arterial occlusive disease (PAD) and abdominal aortic aneurysm (AAA). As blood viscosity is a determinant of wall shear stress, we further investigated the impact of rheologic variables on wall shear stress in relation to vascular risk factors and intima-media thickness.

METHODS

High-resolution ultrasonography scans were used to study intima-media thickness, internal diameter, and blood velocity in the common carotid artery of 31 patients with PAD, 36 patients with AAA, and 37 controls. Furthermore, major hemorheologic variables and vascular risk factors were evaluated, and wall shear stress was calculated.

RESULTS

Wall shear stress was lower in patients with PAD (median [IQR], dynes/cm(2): 14.4 [10 to 19]) and with AAA (12.1 [9 to 15]) than in healthy controls (20.6 [17 to 24]; P < .0001). Wall shear stress was inversely related to red cell aggregation (P = .01), fibrinogen (P = .003), leucocyte count (P = .001), plasma viscosity (P = .04), and intima-media thickness (P < .0001). Furthermore, wall shear stress was negatively associated with age, smoking, and triglycerides, but positively correlated with high-density lipoprotein cholesterol (all P < .001). When the influence of all these predictors were simultaneously taken into account in a multiple regression model, only age (P < .0001), smoking (P = .005), and triglycerides (P = .003) remained significantly associated with wall shear stress.

CONCLUSIONS

This is the first report, to our knowledge, showing that wall shear stress of the common carotid artery is decreased in patients with symptomatic PAD and in patients with AAA. Rheologic variables are less important in predicting wall shear stress than age, triglycerides, and smoking.

Authors+Show Affiliations

Division of Angiology, Department of Medicine, University Hospital Zurich, Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16414387

Citation

Spring, Silviana, et al. "Decreased Wall Shear Stress in the Common Carotid Artery of Patients With Peripheral Arterial Disease or Abdominal Aortic Aneurysm: Relation to Blood Rheology, Vascular Risk Factors, and Intima-media Thickness." Journal of Vascular Surgery, vol. 43, no. 1, 2006, pp. 56-63; discussion 63.
Spring S, van der Loo B, Krieger E, et al. Decreased wall shear stress in the common carotid artery of patients with peripheral arterial disease or abdominal aortic aneurysm: relation to blood rheology, vascular risk factors, and intima-media thickness. J Vasc Surg. 2006;43(1):56-63; discussion 63.
Spring, S., van der Loo, B., Krieger, E., Amann-Vesti, B. R., Rousson, V., & Koppensteiner, R. (2006). Decreased wall shear stress in the common carotid artery of patients with peripheral arterial disease or abdominal aortic aneurysm: relation to blood rheology, vascular risk factors, and intima-media thickness. Journal of Vascular Surgery, 43(1), 56-63; discussion 63.
Spring S, et al. Decreased Wall Shear Stress in the Common Carotid Artery of Patients With Peripheral Arterial Disease or Abdominal Aortic Aneurysm: Relation to Blood Rheology, Vascular Risk Factors, and Intima-media Thickness. J Vasc Surg. 2006;43(1):56-63; discussion 63. PubMed PMID: 16414387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased wall shear stress in the common carotid artery of patients with peripheral arterial disease or abdominal aortic aneurysm: relation to blood rheology, vascular risk factors, and intima-media thickness. AU - Spring,Silviana, AU - van der Loo,Bernd, AU - Krieger,Elisabeth, AU - Amann-Vesti,Beatrice R, AU - Rousson,Valentin, AU - Koppensteiner,Renate, PY - 2005/06/10/received PY - 2005/09/26/accepted PY - 2006/1/18/pubmed PY - 2006/2/24/medline PY - 2006/1/18/entrez SP - 56-63; discussion 63 JF - Journal of vascular surgery JO - J Vasc Surg VL - 43 IS - 1 N2 - BACKGROUND: Wall shear stress, a local risk factor of atherosclerosis, is decreased in the common carotid artery of patients with vascular risk factors. We evaluated wall shear stress in the common carotid artery of patients with symptomatic peripheral arterial occlusive disease (PAD) and abdominal aortic aneurysm (AAA). As blood viscosity is a determinant of wall shear stress, we further investigated the impact of rheologic variables on wall shear stress in relation to vascular risk factors and intima-media thickness. METHODS: High-resolution ultrasonography scans were used to study intima-media thickness, internal diameter, and blood velocity in the common carotid artery of 31 patients with PAD, 36 patients with AAA, and 37 controls. Furthermore, major hemorheologic variables and vascular risk factors were evaluated, and wall shear stress was calculated. RESULTS: Wall shear stress was lower in patients with PAD (median [IQR], dynes/cm(2): 14.4 [10 to 19]) and with AAA (12.1 [9 to 15]) than in healthy controls (20.6 [17 to 24]; P < .0001). Wall shear stress was inversely related to red cell aggregation (P = .01), fibrinogen (P = .003), leucocyte count (P = .001), plasma viscosity (P = .04), and intima-media thickness (P < .0001). Furthermore, wall shear stress was negatively associated with age, smoking, and triglycerides, but positively correlated with high-density lipoprotein cholesterol (all P < .001). When the influence of all these predictors were simultaneously taken into account in a multiple regression model, only age (P < .0001), smoking (P = .005), and triglycerides (P = .003) remained significantly associated with wall shear stress. CONCLUSIONS: This is the first report, to our knowledge, showing that wall shear stress of the common carotid artery is decreased in patients with symptomatic PAD and in patients with AAA. Rheologic variables are less important in predicting wall shear stress than age, triglycerides, and smoking. SN - 0741-5214 UR - https://www.unboundmedicine.com/medline/citation/16414387/Decreased_wall_shear_stress_in_the_common_carotid_artery_of_patients_with_peripheral_arterial_disease_or_abdominal_aortic_aneurysm:_relation_to_blood_rheology_vascular_risk_factors_and_intima_media_thickness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741-5214(05)01702-7 DB - PRIME DP - Unbound Medicine ER -