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High incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms.
Arch Surg. 2006 Jan; 141(1):51-6; discussion 56.AS

Abstract

BACKGROUND

Intraductal papillary mucinous neoplasms (IPMNs) are associated with a high incidence of extrapancreatic neoplasms.

DESIGN

Retrospective study.

SETTING

Tertiary care referral center.

PATIENTS

Sixty-one patients underwent surgical resection for IPMN between January 1, 1993, and June 30, 2004. Thirty-eight patients with mucinous cystic neoplasms and 50 patients with pancreatic ductal adenocarcinoma also were examined for development of extrapancreatic neoplasms.

MAIN OUTCOME MEASURES

The incidence and clinicopathological features of extrapancreatic neoplasms with IPMNs were compared with those with mucinous cystic neoplasm and pancreatic ductal adenocarcinoma.

RESULTS

Of the 61 patients with IPMNs, 24 (39%) developed 26 extrapancreatic neoplasms, and 18 (30%) had extrapancreatic malignancies. Gastric adenocarcinoma (33%) and colorectal adenocarcinoma (17%) were the most common neoplasms in the 24 patients. During postoperative follow-up, 3 patients died of malignant IPMNs, 3 of associated malignancies, and 1 of a nonmalignancy-related cause. Comparisons of the clinicopathological features in patients with IPMNs with and without associated malignancies revealed no significant differences in age, sex, family history of malignancy, history of cigarette smoking or alcohol abuse, or type of IPMN. The incidence of extrapancreatic neoplasms in patients with IPMN was significantly higher than in those with other pancreatic diseases such as mucinous cystic neoplasm (8%) or pancreatic ductal adenocarcinoma (10%).

CONCLUSIONS

Frequently, IPMNs are associated with the development of extrapancreatic neoplasms. Considerable attention should be paid to the possible occurrence of other associated malignancies in patients with IPMNs, either concurrently or postoperatively. Further molecular studies may be necessary to elucidate the unusual association between IPMN and other primary neoplasms.

Authors+Show Affiliations

Department of Surgery, Seoul National University College of Medicine, 20 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16415411

Citation

Choi, Min-Gew, et al. "High Incidence of Extrapancreatic Neoplasms in Patients With Intraductal Papillary Mucinous Neoplasms." Archives of Surgery (Chicago, Ill. : 1960), vol. 141, no. 1, 2006, pp. 51-6; discussion 56.
Choi MG, Kim SW, Han SS, et al. High incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms. Arch Surg. 2006;141(1):51-6; discussion 56.
Choi, M. G., Kim, S. W., Han, S. S., Jang, J. Y., & Park, Y. H. (2006). High incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms. Archives of Surgery (Chicago, Ill. : 1960), 141(1), 51-6; discussion 56.
Choi MG, et al. High Incidence of Extrapancreatic Neoplasms in Patients With Intraductal Papillary Mucinous Neoplasms. Arch Surg. 2006;141(1):51-6; discussion 56. PubMed PMID: 16415411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms. AU - Choi,Min-Gew, AU - Kim,Sun-Whe, AU - Han,Sung-Sik, AU - Jang,Jin-Young, AU - Park,Yong-Hyun, PY - 2006/1/18/pubmed PY - 2006/2/8/medline PY - 2006/1/18/entrez SP - 51-6; discussion 56 JF - Archives of surgery (Chicago, Ill. : 1960) JO - Arch Surg VL - 141 IS - 1 N2 - BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are associated with a high incidence of extrapancreatic neoplasms. DESIGN: Retrospective study. SETTING: Tertiary care referral center. PATIENTS: Sixty-one patients underwent surgical resection for IPMN between January 1, 1993, and June 30, 2004. Thirty-eight patients with mucinous cystic neoplasms and 50 patients with pancreatic ductal adenocarcinoma also were examined for development of extrapancreatic neoplasms. MAIN OUTCOME MEASURES: The incidence and clinicopathological features of extrapancreatic neoplasms with IPMNs were compared with those with mucinous cystic neoplasm and pancreatic ductal adenocarcinoma. RESULTS: Of the 61 patients with IPMNs, 24 (39%) developed 26 extrapancreatic neoplasms, and 18 (30%) had extrapancreatic malignancies. Gastric adenocarcinoma (33%) and colorectal adenocarcinoma (17%) were the most common neoplasms in the 24 patients. During postoperative follow-up, 3 patients died of malignant IPMNs, 3 of associated malignancies, and 1 of a nonmalignancy-related cause. Comparisons of the clinicopathological features in patients with IPMNs with and without associated malignancies revealed no significant differences in age, sex, family history of malignancy, history of cigarette smoking or alcohol abuse, or type of IPMN. The incidence of extrapancreatic neoplasms in patients with IPMN was significantly higher than in those with other pancreatic diseases such as mucinous cystic neoplasm (8%) or pancreatic ductal adenocarcinoma (10%). CONCLUSIONS: Frequently, IPMNs are associated with the development of extrapancreatic neoplasms. Considerable attention should be paid to the possible occurrence of other associated malignancies in patients with IPMNs, either concurrently or postoperatively. Further molecular studies may be necessary to elucidate the unusual association between IPMN and other primary neoplasms. SN - 0004-0010 UR - https://www.unboundmedicine.com/medline/citation/16415411/High_incidence_of_extrapancreatic_neoplasms_in_patients_with_intraductal_papillary_mucinous_neoplasms_ L2 - https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/archsurg.141.1.51 DB - PRIME DP - Unbound Medicine ER -