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Therapy of multidrug resistant typhoid in 58 children.
Scand J Infect Dis. 1992; 24(2):175-9.SJ

Abstract

Treatment of children with infections caused by Salmonella typhi strains resistant to the commonly used oral antimicrobials is a special problem. As children cannot be treated with quinolones, there is no form of oral therapy. Third generation cephalosporins, which have been shown to be effective against typhoid caused by ampicillin sensitive strains of S. typhi were effective against typhoid caused by ampicillin, chloramphenicol and sulfamethoxazole/trimethoprim-resistant strains. We treated 28 children with ceftriaxone and 8 with cefotaxime. We found ceftriaxone to be more effective than cefotaxime with significantly lower relapse rate. Antibiotic therapy of 19 other children, initially treated in a similar manner, was altered for ease of therapy or due to poor response to therapy. The high cost of this parenteral therapy and the problems in its delivery point to the need for safe, effective oral therapy.

Authors+Show Affiliations

Department of Pediatrics, Faculty of Health Sciences, Aga Khan University and Hospital, Karachi, Pakistan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1641594

Citation

Naqvi, S H., et al. "Therapy of Multidrug Resistant Typhoid in 58 Children." Scandinavian Journal of Infectious Diseases, vol. 24, no. 2, 1992, pp. 175-9.
Naqvi SH, Bhutta ZA, Farooqui BJ. Therapy of multidrug resistant typhoid in 58 children. Scand J Infect Dis. 1992;24(2):175-9.
Naqvi, S. H., Bhutta, Z. A., & Farooqui, B. J. (1992). Therapy of multidrug resistant typhoid in 58 children. Scandinavian Journal of Infectious Diseases, 24(2), 175-9.
Naqvi SH, Bhutta ZA, Farooqui BJ. Therapy of Multidrug Resistant Typhoid in 58 Children. Scand J Infect Dis. 1992;24(2):175-9. PubMed PMID: 1641594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapy of multidrug resistant typhoid in 58 children. AU - Naqvi,S H, AU - Bhutta,Z A, AU - Farooqui,B J, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 175 EP - 9 JF - Scandinavian journal of infectious diseases JO - Scand J Infect Dis VL - 24 IS - 2 N2 - Treatment of children with infections caused by Salmonella typhi strains resistant to the commonly used oral antimicrobials is a special problem. As children cannot be treated with quinolones, there is no form of oral therapy. Third generation cephalosporins, which have been shown to be effective against typhoid caused by ampicillin sensitive strains of S. typhi were effective against typhoid caused by ampicillin, chloramphenicol and sulfamethoxazole/trimethoprim-resistant strains. We treated 28 children with ceftriaxone and 8 with cefotaxime. We found ceftriaxone to be more effective than cefotaxime with significantly lower relapse rate. Antibiotic therapy of 19 other children, initially treated in a similar manner, was altered for ease of therapy or due to poor response to therapy. The high cost of this parenteral therapy and the problems in its delivery point to the need for safe, effective oral therapy. SN - 0036-5548 UR - https://www.unboundmedicine.com/medline/citation/1641594/Therapy_of_multidrug_resistant_typhoid_in_58_children_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365549209052609 DB - PRIME DP - Unbound Medicine ER -