Tags

Type your tag names separated by a space and hit enter

Annual conversion to alzheimer disease among patients with memory complaints attending an outpatient memory clinic: the influence of amnestic mild cognitive impairment and the predictive value of neuropsychological testing.
Wien Klin Wochenschr. 2005 Sep; 117(18):629-35.WK

Abstract

OBJECTIVE

The goals of this study were to determine the annual conversion rate to Alzheimer disease (AD) among patients reporting memory problems, including a subgroup with amnestic mild cognitive impairment (aMCI), and to investigate the predictive value of neurocognitive testing for future dementia.

METHODS

A prospective study was carried out in an outpatient memory clinic. One hundred and seven patients underwent a clinical examination and completed a battery of standard cognitive tests at study entry and two years later. The conversion rate to clinically manifested AD two years later was investigated and sensitivity, specificity, receiver operating characteristics (AUC), positive predictive value and negative predictive value for each neuropsychological test were determined.

RESULTS

We found an annual rate of conversion to AD of 6.5% among patients reporting memory decline in the setting of our clinic. Specifically, patients with aMCI had an annual conversion rate of approximately 20%. The annual conversion rate for patients reporting memory problems but showing no memory deficit at memory testing was approximately 3%. Receiver operating characteristics (AUC) of the neuropsychological tests ranged from 0.60 to 0.94.

CONCLUSIONS

Patients with aMCI have 8.6-fold higher odds of developing AD compared with patients without evident memory impairment on neuropsychological testing. Although the risk of developing AD among patients without objective memory decline is small, some patients in this group still convert to AD and therefore close clinical monitoring of patients is necessary.

Authors+Show Affiliations

University Clinic of Neurology, Medical University of Vienna, Vienna, Austria. Johann.Lehrner@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16416345

Citation

Lehrner, Johann, et al. "Annual Conversion to Alzheimer Disease Among Patients With Memory Complaints Attending an Outpatient Memory Clinic: the Influence of Amnestic Mild Cognitive Impairment and the Predictive Value of Neuropsychological Testing." Wiener Klinische Wochenschrift, vol. 117, no. 18, 2005, pp. 629-35.
Lehrner J, Gufler R, Guttmann G, et al. Annual conversion to alzheimer disease among patients with memory complaints attending an outpatient memory clinic: the influence of amnestic mild cognitive impairment and the predictive value of neuropsychological testing. Wien Klin Wochenschr. 2005;117(18):629-35.
Lehrner, J., Gufler, R., Guttmann, G., Maly, J., Gleiss, A., Auff, E., & Dal-Bianco, P. (2005). Annual conversion to alzheimer disease among patients with memory complaints attending an outpatient memory clinic: the influence of amnestic mild cognitive impairment and the predictive value of neuropsychological testing. Wiener Klinische Wochenschrift, 117(18), 629-35.
Lehrner J, et al. Annual Conversion to Alzheimer Disease Among Patients With Memory Complaints Attending an Outpatient Memory Clinic: the Influence of Amnestic Mild Cognitive Impairment and the Predictive Value of Neuropsychological Testing. Wien Klin Wochenschr. 2005;117(18):629-35. PubMed PMID: 16416345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Annual conversion to alzheimer disease among patients with memory complaints attending an outpatient memory clinic: the influence of amnestic mild cognitive impairment and the predictive value of neuropsychological testing. AU - Lehrner,Johann, AU - Gufler,Renate, AU - Guttmann,Giselher, AU - Maly,Joachim, AU - Gleiss,Andreas, AU - Auff,Eduard, AU - Dal-Bianco,Peter, PY - 2005/01/31/received PY - 2005/05/30/accepted PY - 2006/1/18/pubmed PY - 2006/2/10/medline PY - 2006/1/18/entrez SP - 629 EP - 35 JF - Wiener klinische Wochenschrift JO - Wien. Klin. Wochenschr. VL - 117 IS - 18 N2 - OBJECTIVE: The goals of this study were to determine the annual conversion rate to Alzheimer disease (AD) among patients reporting memory problems, including a subgroup with amnestic mild cognitive impairment (aMCI), and to investigate the predictive value of neurocognitive testing for future dementia. METHODS: A prospective study was carried out in an outpatient memory clinic. One hundred and seven patients underwent a clinical examination and completed a battery of standard cognitive tests at study entry and two years later. The conversion rate to clinically manifested AD two years later was investigated and sensitivity, specificity, receiver operating characteristics (AUC), positive predictive value and negative predictive value for each neuropsychological test were determined. RESULTS: We found an annual rate of conversion to AD of 6.5% among patients reporting memory decline in the setting of our clinic. Specifically, patients with aMCI had an annual conversion rate of approximately 20%. The annual conversion rate for patients reporting memory problems but showing no memory deficit at memory testing was approximately 3%. Receiver operating characteristics (AUC) of the neuropsychological tests ranged from 0.60 to 0.94. CONCLUSIONS: Patients with aMCI have 8.6-fold higher odds of developing AD compared with patients without evident memory impairment on neuropsychological testing. Although the risk of developing AD among patients without objective memory decline is small, some patients in this group still convert to AD and therefore close clinical monitoring of patients is necessary. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/16416345/Annual_conversion_to_alzheimer_disease_among_patients_with_memory_complaints_attending_an_outpatient_memory_clinic:_the_influence_of_amnestic_mild_cognitive_impairment_and_the_predictive_value_of_neuropsychological_testing_ L2 - https://dx.doi.org/10.1007/s00508-005-0428-6 DB - PRIME DP - Unbound Medicine ER -