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Identification of the epileptogenic tuber in patients with tuberous sclerosis: a comparison of high-resolution EEG and MEG.
Epilepsia. 2006 Jan; 47(1):108-14.E

Abstract

PURPOSE

We compared epileptiform activity recorded with EEG and magnetoencephalography (MEG) in 19 patients with tuberous sclerosis complex (TSC) and epilepsy.

METHODS

High-resolution (HR) EEG, HR-MEG, and 1.5-T MRI scans were performed. Epileptiform spikes were identified in EEG and MEG recordings offline by three observers. Spikes for which the interobserver agreement (spike consensus) was >0.40 were used for source localization with CURRYV 3.0 software. MUSIC analysis was performed. The distance between the source determined from EEG and MEG recordings and the border of the closest tuber was calculated and compared.

RESULTS

Consensus spikes (kappa >0.4) were identified in 12 patients in the EEG recording and in 14 patients in the MEG recording. MEG sources were closer to tubers in all but one patient. Three patients underwent epilepsy surgery, two of whom are seizure free after complete resection of the tuber.

CONCLUSIONS

In patients with TSC, epileptogenic sources identified on MEG are closer to the presumed epileptogenic tuber than are similar sources identified on EEG. Moreover, spike consensus is greater with MEG. Clear identification of the epileptogenic zone may offer opportunities for surgery in patients with TSC with intractable epilepsy.

Authors+Show Affiliations

Department of Clinical Neurophysiology, University Medical Center, Utrecht, The Netherlands. f.e.jansen@neuro.azu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16417538

Citation

Jansen, Floor E., et al. "Identification of the Epileptogenic Tuber in Patients With Tuberous Sclerosis: a Comparison of High-resolution EEG and MEG." Epilepsia, vol. 47, no. 1, 2006, pp. 108-14.
Jansen FE, Huiskamp G, van Huffelen AC, et al. Identification of the epileptogenic tuber in patients with tuberous sclerosis: a comparison of high-resolution EEG and MEG. Epilepsia. 2006;47(1):108-14.
Jansen, F. E., Huiskamp, G., van Huffelen, A. C., Bourez-Swart, M., Boere, E., Gebbink, T., Vincken, K. L., & van Nieuwenhuizen, O. (2006). Identification of the epileptogenic tuber in patients with tuberous sclerosis: a comparison of high-resolution EEG and MEG. Epilepsia, 47(1), 108-14.
Jansen FE, et al. Identification of the Epileptogenic Tuber in Patients With Tuberous Sclerosis: a Comparison of High-resolution EEG and MEG. Epilepsia. 2006;47(1):108-14. PubMed PMID: 16417538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of the epileptogenic tuber in patients with tuberous sclerosis: a comparison of high-resolution EEG and MEG. AU - Jansen,Floor E, AU - Huiskamp,Geertjan, AU - van Huffelen,Alexander C, AU - Bourez-Swart,Mireille, AU - Boere,Elvira, AU - Gebbink,Tineke, AU - Vincken,Koen L, AU - van Nieuwenhuizen,Onno, PY - 2006/1/19/pubmed PY - 2006/4/12/medline PY - 2006/1/19/entrez SP - 108 EP - 14 JF - Epilepsia JO - Epilepsia VL - 47 IS - 1 N2 - PURPOSE: We compared epileptiform activity recorded with EEG and magnetoencephalography (MEG) in 19 patients with tuberous sclerosis complex (TSC) and epilepsy. METHODS: High-resolution (HR) EEG, HR-MEG, and 1.5-T MRI scans were performed. Epileptiform spikes were identified in EEG and MEG recordings offline by three observers. Spikes for which the interobserver agreement (spike consensus) was >0.40 were used for source localization with CURRYV 3.0 software. MUSIC analysis was performed. The distance between the source determined from EEG and MEG recordings and the border of the closest tuber was calculated and compared. RESULTS: Consensus spikes (kappa >0.4) were identified in 12 patients in the EEG recording and in 14 patients in the MEG recording. MEG sources were closer to tubers in all but one patient. Three patients underwent epilepsy surgery, two of whom are seizure free after complete resection of the tuber. CONCLUSIONS: In patients with TSC, epileptogenic sources identified on MEG are closer to the presumed epileptogenic tuber than are similar sources identified on EEG. Moreover, spike consensus is greater with MEG. Clear identification of the epileptogenic zone may offer opportunities for surgery in patients with TSC with intractable epilepsy. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/16417538/Identification_of_the_epileptogenic_tuber_in_patients_with_tuberous_sclerosis:_a_comparison_of_high_resolution_EEG_and_MEG_ L2 - https://doi.org/10.1111/j.1528-1167.2006.00373.x DB - PRIME DP - Unbound Medicine ER -