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Evaluation of the mutagenic and antimutagenic effects of South African plants.
J Ethnopharmacol. 2006 Jun 15; 106(1):44-50.JE

Abstract

Dichloromethane and 90% methanol extracts of 42 South African plants were screened for mutagenicity and antimutagenicity using the Salmonella/microsome mutagenicity assay (Ames) against Salmonella typhimurium TA98 and TA100 bacterial strains in the presence and absence of metabolic activator S9. The methanol extracts from whole plants of Helichrysum simillimum, Helichrysum herbaceum and Helichrysum rugulosum indicated mutagenicity. These are the first reported tests on the mutagenicity of Helichrysum species. Six species indicated antimutagenic properties, all in the presence of S9: methanol leaf extract of Bauhinia galpinii, and dichloromethane leaf extracts of Bauhinia galpinii, Clerodendrum myricoides, Datura stramonium, Buddleja saligna, Millettia sutherlandii and Sutherlandia frutescens.

Authors+Show Affiliations

Reid KA
Expertise Centre of Environmental Toxicology, Flemish Institute for Technological Research (Vito), Boeretang 200, B-2400 Mol, Belgium.
Maes J
No affiliation info available
Maes A
No affiliation info available
van Staden J
No affiliation info available
De Kimpe N
No affiliation info available
Mulholland DA
No affiliation info available
Verschaeve L
No affiliation info available

MeSH

Antimutagenic AgentsDatura stramoniumHelichrysumMedicine, African TraditionalMethanolMethylene ChlorideMutagenicity TestsMutagensPlant ExtractsPlantsSalmonella typhimuriumSouth Africa

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16417980

Citation

Reid, K A., et al. "Evaluation of the Mutagenic and Antimutagenic Effects of South African Plants." Journal of Ethnopharmacology, vol. 106, no. 1, 2006, pp. 44-50.
Reid KA, Maes J, Maes A, et al. Evaluation of the mutagenic and antimutagenic effects of South African plants. J Ethnopharmacol. 2006;106(1):44-50.
Reid, K. A., Maes, J., Maes, A., van Staden, J., De Kimpe, N., Mulholland, D. A., & Verschaeve, L. (2006). Evaluation of the mutagenic and antimutagenic effects of South African plants. Journal of Ethnopharmacology, 106(1), 44-50.
Reid KA, et al. Evaluation of the Mutagenic and Antimutagenic Effects of South African Plants. J Ethnopharmacol. 2006 Jun 15;106(1):44-50. PubMed PMID: 16417980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the mutagenic and antimutagenic effects of South African plants. AU - Reid,K A, AU - Maes,J, AU - Maes,A, AU - van Staden,J, AU - De Kimpe,N, AU - Mulholland,D A, AU - Verschaeve,L, Y1 - 2006/01/18/ PY - 2005/02/07/received PY - 2005/11/21/revised PY - 2005/11/23/accepted PY - 2006/1/19/pubmed PY - 2006/11/15/medline PY - 2006/1/19/entrez SP - 44 EP - 50 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 106 IS - 1 N2 - Dichloromethane and 90% methanol extracts of 42 South African plants were screened for mutagenicity and antimutagenicity using the Salmonella/microsome mutagenicity assay (Ames) against Salmonella typhimurium TA98 and TA100 bacterial strains in the presence and absence of metabolic activator S9. The methanol extracts from whole plants of Helichrysum simillimum, Helichrysum herbaceum and Helichrysum rugulosum indicated mutagenicity. These are the first reported tests on the mutagenicity of Helichrysum species. Six species indicated antimutagenic properties, all in the presence of S9: methanol leaf extract of Bauhinia galpinii, and dichloromethane leaf extracts of Bauhinia galpinii, Clerodendrum myricoides, Datura stramonium, Buddleja saligna, Millettia sutherlandii and Sutherlandia frutescens. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16417980/Evaluation_of_the_mutagenic_and_antimutagenic_effects_of_South_African_plants_ DB - PRIME DP - Unbound Medicine ER -