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Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia.
Reg Anesth Pain Med. 2006 Jan-Feb; 31(1):40-5.RA

Abstract

BACKGROUND AND OBJECTIVES

Perioperative hypothermia is a common problem in anesthesia practice. Regional anesthesia, like general anesthesia, influences the thermoregulatory process. The aim of our study was to compare the efficacy of ondansetron and meperidine in the prevention of shivering during and after spinal anesthesia.

METHODS

In this double-blind study, 75 patients were randomized into 3 groups. Group O and Group M were given ondansetron 8 mg and meperidine 0.4 mg/kg intravenously immediately before spinal anesthesia, respectively. Group C received saline at identical times. The core temperatures and the incidence of shivering were recorded. Association between maximum block height and mean rectal temperatures of the patients were also evaluated.

RESULTS

The core temperature was preserved in both ondansetron and meperidine groups with respect to the control group. Shivering was observed in 8% of patients in groups O and M and 36% in group C. The correlation between maximum block height and mean rectal temperatures was lost in the ondansetron and meperidine groups.

CONCLUSION

Ondansetron and meperidine have similar anti-shivering effects. In addition, both ondansetron and meperidine altered the correlation between the core temperature and block level during spinal anesthesia.

Authors+Show Affiliations

Department of Anesthesiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey. ebruk@omu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16418023

Citation

Kelsaka, Ebru, et al. "Comparison of Ondansetron and Meperidine for Prevention of Shivering in Patients Undergoing Spinal Anesthesia." Regional Anesthesia and Pain Medicine, vol. 31, no. 1, 2006, pp. 40-5.
Kelsaka E, Baris S, Karakaya D, et al. Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia. Reg Anesth Pain Med. 2006;31(1):40-5.
Kelsaka, E., Baris, S., Karakaya, D., & Sarihasan, B. (2006). Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia. Regional Anesthesia and Pain Medicine, 31(1), 40-5.
Kelsaka E, et al. Comparison of Ondansetron and Meperidine for Prevention of Shivering in Patients Undergoing Spinal Anesthesia. Reg Anesth Pain Med. 2006 Jan-Feb;31(1):40-5. PubMed PMID: 16418023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia. AU - Kelsaka,Ebru, AU - Baris,Sibel, AU - Karakaya,Deniz, AU - Sarihasan,Binnur, PY - 2005/04/10/received PY - 2005/10/17/revised PY - 2005/10/17/accepted PY - 2006/1/19/pubmed PY - 2006/5/19/medline PY - 2006/1/19/entrez SP - 40 EP - 5 JF - Regional anesthesia and pain medicine JO - Reg Anesth Pain Med VL - 31 IS - 1 N2 - BACKGROUND AND OBJECTIVES: Perioperative hypothermia is a common problem in anesthesia practice. Regional anesthesia, like general anesthesia, influences the thermoregulatory process. The aim of our study was to compare the efficacy of ondansetron and meperidine in the prevention of shivering during and after spinal anesthesia. METHODS: In this double-blind study, 75 patients were randomized into 3 groups. Group O and Group M were given ondansetron 8 mg and meperidine 0.4 mg/kg intravenously immediately before spinal anesthesia, respectively. Group C received saline at identical times. The core temperatures and the incidence of shivering were recorded. Association between maximum block height and mean rectal temperatures of the patients were also evaluated. RESULTS: The core temperature was preserved in both ondansetron and meperidine groups with respect to the control group. Shivering was observed in 8% of patients in groups O and M and 36% in group C. The correlation between maximum block height and mean rectal temperatures was lost in the ondansetron and meperidine groups. CONCLUSION: Ondansetron and meperidine have similar anti-shivering effects. In addition, both ondansetron and meperidine altered the correlation between the core temperature and block level during spinal anesthesia. SN - 1098-7339 UR - https://www.unboundmedicine.com/medline/citation/16418023/Comparison_of_ondansetron_and_meperidine_for_prevention_of_shivering_in_patients_undergoing_spinal_anesthesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1098-7339(05)00564-X DB - PRIME DP - Unbound Medicine ER -