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Coeliac disease in patients with Kawasaki disease. Is there a link?
Rheumatology (Oxford) 2006; 45(7):847-50R

Abstract

OBJECTIVE

Kawasaki disease (KD) is an acute febrile systemic vasculitis, mainly affecting infants and young children. Immunological abnormalities during the acute phase of KD have been described extensively. However, the occurrence of a second immunological disorder in a patient with a history of KD is rarely reported. We evaluated the presence of autoimmune thyroiditis and coeliac disease (CD) in patients with KD diagnosis.

METHODS

Ninety consecutive children (57 males and 33 females, median age 5.2 yr, age range 1.6-14.1 yr) with KD were evaluated. All patients were evaluated for thyroid function (thyroid-stimulating hormone, thyroxine and triiodothyronine), anti-thyroglobulin (TgA) and anti-peroxidase (TPOA) antibodies, and antigliadin, anti-endomysium and antitransglutaminase antibodies. CD was confirmed by jejunal biopsy if the specific antibody profile was positive. One hundred and fifty Italian children, matched for age and sex and from the same geographic area, acted as controls.

RESULTS

A total of five patients (three boys, two girls; 5.5%; P<0.05) were found positive for coeliac antibodies. In all of these patients the diagnosis of CD was confirmed histologically. Regarding thyroid function and autoantibodies, no patient showed subclinical hypothyroidism or autoimmune thyroiditis. No differences in the familial occurrence of autoimmune diseases between KD patients and controls were found (9.1 and 7.9%, respectively).

CONCLUSIONS

Our data showed a higher prevalence of CD in children with KD, and this suggests that children with KD should be monitored carefully for CD. However, there was no increase in the prevalence of autoimmune thyroid diseases in patients with KD or the familial occurrence of autoimmune diseases.

Authors+Show Affiliations

Department of Paediatrics, Paediatric Rheumatology Unit, University of Florence, Florence, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16418194

Citation

Stagi, S, et al. "Coeliac Disease in Patients With Kawasaki Disease. Is There a Link?" Rheumatology (Oxford, England), vol. 45, no. 7, 2006, pp. 847-50.
Stagi S, Simonini G, Ricci L, et al. Coeliac disease in patients with Kawasaki disease. Is there a link? Rheumatology (Oxford). 2006;45(7):847-50.
Stagi, S., Simonini, G., Ricci, L., de Martino, M., & Falcini, F. (2006). Coeliac disease in patients with Kawasaki disease. Is there a link? Rheumatology (Oxford, England), 45(7), pp. 847-50.
Stagi S, et al. Coeliac Disease in Patients With Kawasaki Disease. Is There a Link. Rheumatology (Oxford). 2006;45(7):847-50. PubMed PMID: 16418194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coeliac disease in patients with Kawasaki disease. Is there a link? AU - Stagi,S, AU - Simonini,G, AU - Ricci,L, AU - de Martino,M, AU - Falcini,F, Y1 - 2006/01/17/ PY - 2006/1/19/pubmed PY - 2006/8/17/medline PY - 2006/1/19/entrez SP - 847 EP - 50 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 45 IS - 7 N2 - OBJECTIVE: Kawasaki disease (KD) is an acute febrile systemic vasculitis, mainly affecting infants and young children. Immunological abnormalities during the acute phase of KD have been described extensively. However, the occurrence of a second immunological disorder in a patient with a history of KD is rarely reported. We evaluated the presence of autoimmune thyroiditis and coeliac disease (CD) in patients with KD diagnosis. METHODS: Ninety consecutive children (57 males and 33 females, median age 5.2 yr, age range 1.6-14.1 yr) with KD were evaluated. All patients were evaluated for thyroid function (thyroid-stimulating hormone, thyroxine and triiodothyronine), anti-thyroglobulin (TgA) and anti-peroxidase (TPOA) antibodies, and antigliadin, anti-endomysium and antitransglutaminase antibodies. CD was confirmed by jejunal biopsy if the specific antibody profile was positive. One hundred and fifty Italian children, matched for age and sex and from the same geographic area, acted as controls. RESULTS: A total of five patients (three boys, two girls; 5.5%; P<0.05) were found positive for coeliac antibodies. In all of these patients the diagnosis of CD was confirmed histologically. Regarding thyroid function and autoantibodies, no patient showed subclinical hypothyroidism or autoimmune thyroiditis. No differences in the familial occurrence of autoimmune diseases between KD patients and controls were found (9.1 and 7.9%, respectively). CONCLUSIONS: Our data showed a higher prevalence of CD in children with KD, and this suggests that children with KD should be monitored carefully for CD. However, there was no increase in the prevalence of autoimmune thyroid diseases in patients with KD or the familial occurrence of autoimmune diseases. SN - 1462-0324 UR - https://www.unboundmedicine.com/medline/citation/16418194/Coeliac_disease_in_patients_with_Kawasaki_disease__Is_there_a_link L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kel007 DB - PRIME DP - Unbound Medicine ER -