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[Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database].
Klin Monbl Augenheilkd. 2005 Dec; 222(12):993-1001.KM

Abstract

BACKGROUND

Uveitis is a frequent and potentially vision-threatening manifestation of juvenile idiopathic arthritis (JIA). There are only a few population-based studies providing data on the frequency and severity of uveitis.

METHODS

Documentation of patients with JIA was collected in a national database. An analysis of the paediatric rheumatologic and ophthalmologic data collected from all patients that were included in 2002 was performed.

RESULTS

Uveitis was documented in 12 % of a total of 3271 JIA patients: extended oligoarthritis (25 %), persistent oligoarthritis (16 %), seronegative polyarthritis (4 %), seropositive polyarthritis (2 %), psoriatic arthritis (10 %), enthesitis-related arthritis (ERA) (7 %), systemic arthritis (1 %), other arthritis forms (11 %). Ophthalmologic data were available from 115 uveitis patients (28 %). Mean age at onset of uveitis was 5.2 (SD 3.2) years. JIA patients with uveitis were significantly younger at onset of arthritis (3.8 vs. 7.0 years), and were more often girls (74 vs. 63 %) or ANA-positive (86 vs. 42 %) than the patients without uveitis. Uveitis complications were present in 45 % at initial presentation of uveitis. After a mean duration of 5.6 years, complications were noted in 56 %, and included band keratopathy (29 %), posterior synechiae (27 %), cataract (26 %), glaucoma (8 %), and macula oedema (6 %). Final visual acuity was less than 20/50 in 31 % and less than 20/200 in 12 % of eyes. In patients with uveitis, immunosuppressive or immunomodulatory drugs were used significantly more often than in patients without uveitis (75 % vs. 43 %).

CONCLUSIONS

The nationwide data documents the spectrum of uveitis in patients with JIA, the complications and the therapy for uveitis. The high rate of uveitis complications at the time of diagnosis points out the need for early ophthalmologic screening and therapy, and for a close collaboration between ophthalmologist and paediatric rheumatologist.

Authors+Show Affiliations

Heiligenhaus A
Augenabteilung am St.-Franziskus-Hospital, Münster. arnd.heiligenhaus@uveitis-zentrum.de
Niewerth M
No affiliation info available
Mingels A
No affiliation info available
Ganser G
No affiliation info available
Thon A
No affiliation info available
Pleyer U
No affiliation info available
Greiner K
No affiliation info available
Minden K
No affiliation info available

MeSH

AdolescentArthritis, JuvenileChildChild, PreschoolComorbidityDatabases, FactualFemaleHumansInfantInfant, NewbornMaleMedical Records Systems, ComputerizedOphthalmologyPediatricsPrevalenceRegistriesRetrospective StudiesRheumatologyRisk AssessmentRisk FactorsUveitisVision Disorders

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

16418970

Citation

Heiligenhaus, A, et al. "[Epidemiology of Uveitis in Juvenile Idiopathic Arthritis From a National Paediatric Rheumatologic and Ophthalmologic Database]." Klinische Monatsblatter Fur Augenheilkunde, vol. 222, no. 12, 2005, pp. 993-1001.
Heiligenhaus A, Niewerth M, Mingels A, et al. [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database]. Klin Monbl Augenheilkd. 2005;222(12):993-1001.
Heiligenhaus, A., Niewerth, M., Mingels, A., Ganser, G., Thon, A., Pleyer, U., Greiner, K., & Minden, K. (2005). [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database]. Klinische Monatsblatter Fur Augenheilkunde, 222(12), 993-1001.
Heiligenhaus A, et al. [Epidemiology of Uveitis in Juvenile Idiopathic Arthritis From a National Paediatric Rheumatologic and Ophthalmologic Database]. Klin Monbl Augenheilkd. 2005;222(12):993-1001. PubMed PMID: 16418970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database]. AU - Heiligenhaus,A, AU - Niewerth,M, AU - Mingels,A, AU - Ganser,G, AU - Thon,A, AU - Pleyer,U, AU - Greiner,K, AU - Minden,K, PY - 2006/1/19/pubmed PY - 2006/3/1/medline PY - 2006/1/19/entrez SP - 993 EP - 1001 JF - Klinische Monatsblatter fur Augenheilkunde JO - Klin Monbl Augenheilkd VL - 222 IS - 12 N2 - BACKGROUND: Uveitis is a frequent and potentially vision-threatening manifestation of juvenile idiopathic arthritis (JIA). There are only a few population-based studies providing data on the frequency and severity of uveitis. METHODS: Documentation of patients with JIA was collected in a national database. An analysis of the paediatric rheumatologic and ophthalmologic data collected from all patients that were included in 2002 was performed. RESULTS: Uveitis was documented in 12 % of a total of 3271 JIA patients: extended oligoarthritis (25 %), persistent oligoarthritis (16 %), seronegative polyarthritis (4 %), seropositive polyarthritis (2 %), psoriatic arthritis (10 %), enthesitis-related arthritis (ERA) (7 %), systemic arthritis (1 %), other arthritis forms (11 %). Ophthalmologic data were available from 115 uveitis patients (28 %). Mean age at onset of uveitis was 5.2 (SD 3.2) years. JIA patients with uveitis were significantly younger at onset of arthritis (3.8 vs. 7.0 years), and were more often girls (74 vs. 63 %) or ANA-positive (86 vs. 42 %) than the patients without uveitis. Uveitis complications were present in 45 % at initial presentation of uveitis. After a mean duration of 5.6 years, complications were noted in 56 %, and included band keratopathy (29 %), posterior synechiae (27 %), cataract (26 %), glaucoma (8 %), and macula oedema (6 %). Final visual acuity was less than 20/50 in 31 % and less than 20/200 in 12 % of eyes. In patients with uveitis, immunosuppressive or immunomodulatory drugs were used significantly more often than in patients without uveitis (75 % vs. 43 %). CONCLUSIONS: The nationwide data documents the spectrum of uveitis in patients with JIA, the complications and the therapy for uveitis. The high rate of uveitis complications at the time of diagnosis points out the need for early ophthalmologic screening and therapy, and for a close collaboration between ophthalmologist and paediatric rheumatologist. SN - 0023-2165 UR - https://www.unboundmedicine.com/medline/citation/16418970/[Epidemiology_of_uveitis_in_juvenile_idiopathic_arthritis_from_a_national_paediatric_rheumatologic_and_ophthalmologic_database]_ DB - PRIME DP - Unbound Medicine ER -