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Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study.
J Am Geriatr Soc 2006; 54(1):30-7JA

Abstract

OBJECTIVES

To evaluate several aspects of the relationship between alcohol use and coronary heart disease in older adults, including beverage type, mediating factors, and type of outcome.

DESIGN

Prospective cohort study.

SETTING

Four U.S. communities.

PARTICIPANTS

Four thousand four hundred ten adults aged 65 and older free of cardiovascular disease at baseline.

MEASUREMENTS

Risk of incident myocardial infarction or coronary death according to self-reported consumption of beer, wine, and spirits ascertained yearly.

RESULTS

During an average follow-up period of 9.2 years, 675 cases of incident myocardial infarction or coronary death occurred. Compared with long-term abstainers, multivariate relative risks of 0.90 (95% confidence interval (CI)=0.71-1.14), 0.93 (95% CI=0.73-1.20), 0.76 (95% CI=0.53-1.10), and 0.58 (95% CI=0.39-0.86) were found in consumers of less than one, one to six, seven to 13, and 14 or more drinks per week, respectively (P for trend=.007). Associations were similar for secondary coronary outcomes, including nonfatal and fatal events. No strong mediators of the association were identified, although fibrinogen appeared to account for 9% to 10% of the relationship. The associations were statistically similar for intake of wine, beer, and liquor and generally similar in subgroups, including those with and without an apolipoprotein E4 allele.

CONCLUSION

In this population, consumption of 14 or more drinks per week was associated with the lowest risk of coronary heart disease, although clinicians should not recommend moderate drinking to prevent coronary heart disease based on this evidence alone, because current National Institute on Alcohol Abuse and Alcoholism guidelines suggest that older adults limit alcohol intake to one drink per day.

Authors+Show Affiliations

Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. kmukamal@bidmc.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16420195

Citation

Mukamal, Kenneth J., et al. "Alcohol Consumption and Risk of Coronary Heart Disease in Older Adults: the Cardiovascular Health Study." Journal of the American Geriatrics Society, vol. 54, no. 1, 2006, pp. 30-7.
Mukamal KJ, Chung H, Jenny NS, et al. Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study. J Am Geriatr Soc. 2006;54(1):30-7.
Mukamal, K. J., Chung, H., Jenny, N. S., Kuller, L. H., Longstreth, W. T., Mittleman, M. A., ... Siscovick, D. S. (2006). Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study. Journal of the American Geriatrics Society, 54(1), pp. 30-7.
Mukamal KJ, et al. Alcohol Consumption and Risk of Coronary Heart Disease in Older Adults: the Cardiovascular Health Study. J Am Geriatr Soc. 2006;54(1):30-7. PubMed PMID: 16420195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study. AU - Mukamal,Kenneth J, AU - Chung,Hyoju, AU - Jenny,Nancy S, AU - Kuller,Lewis H, AU - Longstreth,W T,Jr AU - Mittleman,Murray A, AU - Burke,Gregory L, AU - Cushman,Mary, AU - Psaty,Bruce M, AU - Siscovick,David S, PY - 2006/1/20/pubmed PY - 2006/4/8/medline PY - 2006/1/20/entrez SP - 30 EP - 7 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 54 IS - 1 N2 - OBJECTIVES: To evaluate several aspects of the relationship between alcohol use and coronary heart disease in older adults, including beverage type, mediating factors, and type of outcome. DESIGN: Prospective cohort study. SETTING: Four U.S. communities. PARTICIPANTS: Four thousand four hundred ten adults aged 65 and older free of cardiovascular disease at baseline. MEASUREMENTS: Risk of incident myocardial infarction or coronary death according to self-reported consumption of beer, wine, and spirits ascertained yearly. RESULTS: During an average follow-up period of 9.2 years, 675 cases of incident myocardial infarction or coronary death occurred. Compared with long-term abstainers, multivariate relative risks of 0.90 (95% confidence interval (CI)=0.71-1.14), 0.93 (95% CI=0.73-1.20), 0.76 (95% CI=0.53-1.10), and 0.58 (95% CI=0.39-0.86) were found in consumers of less than one, one to six, seven to 13, and 14 or more drinks per week, respectively (P for trend=.007). Associations were similar for secondary coronary outcomes, including nonfatal and fatal events. No strong mediators of the association were identified, although fibrinogen appeared to account for 9% to 10% of the relationship. The associations were statistically similar for intake of wine, beer, and liquor and generally similar in subgroups, including those with and without an apolipoprotein E4 allele. CONCLUSION: In this population, consumption of 14 or more drinks per week was associated with the lowest risk of coronary heart disease, although clinicians should not recommend moderate drinking to prevent coronary heart disease based on this evidence alone, because current National Institute on Alcohol Abuse and Alcoholism guidelines suggest that older adults limit alcohol intake to one drink per day. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/16420195/Alcohol_consumption_and_risk_of_coronary_heart_disease_in_older_adults:_the_Cardiovascular_Health_Study_ L2 - https://doi.org/10.1111/j.1532-5415.2005.00561.x DB - PRIME DP - Unbound Medicine ER -