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Measures of adiposity and risk of breast cancer in older postmenopausal women.
J Am Geriatr Soc 2006; 54(1):63-9JA

Abstract

OBJECTIVES

To determine whether higher adiposity is associated with greater breast cancer risk in older postmenopausal women.

DESIGN

Prospective cohort study with mean follow-up of 11.3 years.

SETTING

Four U.S. clinical centers.

PARTICIPANTS

Seven thousand five hundred twenty-three women (mean age 73.5) enrolled in the Study of Osteoporotic Fractures.

MEASUREMENTS

Weight, height, and waist and hip circumference were measured at baseline. Body composition was determined using bioelectrical impedance. Risk factor information was obtained by interview and questionnaire. Bone mineral density was measured using dual energy x-ray absorptiometry. The outcome was incident invasive breast cancer, confirmed using medical records.

RESULTS

After adjustment for multiple risk factors, including bone density, women in the uppermost quartiles of weight, weight gain since age 25, body mass index, waist circumference, and percentage of body fat had higher breast cancer rates than women in the first quartiles of each measure. For example, breast cancer rates were 49% higher for women in the uppermost quartile of weight (hazard ratio (HR)=1.49, 95% confidence interval (CI)=1.05-2.10), 64% higher for women in the top quartile of weight gain since age 25 (HR=1.64, 95% CI=1.15-2.34), and 58% higher for women in the top quartile of percentage of body fat (HR=1.58, 95% CI=1.11-2.23) than for women in the lowest quartile of each measure. The associations between adiposity measures and breast cancer rates were not altered when the analyses were limited to very elderly women (> or = 70).

CONCLUSION

Higher adiposity is an independent risk factor for breast cancer in elderly women.

Authors+Show Affiliations

Robert Wood Johnson Clinical Scholars Program and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA. krebs@med.unc.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16420199

Citation

Krebs, Erin E., et al. "Measures of Adiposity and Risk of Breast Cancer in Older Postmenopausal Women." Journal of the American Geriatrics Society, vol. 54, no. 1, 2006, pp. 63-9.
Krebs EE, Taylor BC, Cauley JA, et al. Measures of adiposity and risk of breast cancer in older postmenopausal women. J Am Geriatr Soc. 2006;54(1):63-9.
Krebs, E. E., Taylor, B. C., Cauley, J. A., Stone, K. L., Bowman, P. J., & Ensrud, K. E. (2006). Measures of adiposity and risk of breast cancer in older postmenopausal women. Journal of the American Geriatrics Society, 54(1), pp. 63-9.
Krebs EE, et al. Measures of Adiposity and Risk of Breast Cancer in Older Postmenopausal Women. J Am Geriatr Soc. 2006;54(1):63-9. PubMed PMID: 16420199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measures of adiposity and risk of breast cancer in older postmenopausal women. AU - Krebs,Erin E, AU - Taylor,Brent C, AU - Cauley,Jane A, AU - Stone,Katie L, AU - Bowman,Paula J, AU - Ensrud,Kristine E, PY - 2006/1/20/pubmed PY - 2006/4/8/medline PY - 2006/1/20/entrez SP - 63 EP - 9 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 54 IS - 1 N2 - OBJECTIVES: To determine whether higher adiposity is associated with greater breast cancer risk in older postmenopausal women. DESIGN: Prospective cohort study with mean follow-up of 11.3 years. SETTING: Four U.S. clinical centers. PARTICIPANTS: Seven thousand five hundred twenty-three women (mean age 73.5) enrolled in the Study of Osteoporotic Fractures. MEASUREMENTS: Weight, height, and waist and hip circumference were measured at baseline. Body composition was determined using bioelectrical impedance. Risk factor information was obtained by interview and questionnaire. Bone mineral density was measured using dual energy x-ray absorptiometry. The outcome was incident invasive breast cancer, confirmed using medical records. RESULTS: After adjustment for multiple risk factors, including bone density, women in the uppermost quartiles of weight, weight gain since age 25, body mass index, waist circumference, and percentage of body fat had higher breast cancer rates than women in the first quartiles of each measure. For example, breast cancer rates were 49% higher for women in the uppermost quartile of weight (hazard ratio (HR)=1.49, 95% confidence interval (CI)=1.05-2.10), 64% higher for women in the top quartile of weight gain since age 25 (HR=1.64, 95% CI=1.15-2.34), and 58% higher for women in the top quartile of percentage of body fat (HR=1.58, 95% CI=1.11-2.23) than for women in the lowest quartile of each measure. The associations between adiposity measures and breast cancer rates were not altered when the analyses were limited to very elderly women (> or = 70). CONCLUSION: Higher adiposity is an independent risk factor for breast cancer in elderly women. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/16420199/Measures_of_adiposity_and_risk_of_breast_cancer_in_older_postmenopausal_women_ L2 - https://doi.org/10.1111/j.1532-5415.2005.00541.x DB - PRIME DP - Unbound Medicine ER -